KEGG   DRUG: Garadacimab
Entry
D12613                      Drug                                   
Name
Garadacimab (INN);
Garadacimab (genetical recombination) (JAN);
Andembry (TN)
Product
Formula
C6470H10004N1724O2022S42
Exact mass
145548.1256
Mol weight
145637.80
Sequence
(Heavy chain)
XVQLLESGGG LVQPGGSLRL SCAASGFTFS KYIMQWVRQA PGKGLEWVSG IDIPTKGTVY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARAL PRSGYLISPH YYYYALDVWG
QGTTVTVSSA STKGPSVFPL APCSRSTSES TAALGCLVKD YFPEPVTVSW NSGALTSGVH
TFPAVLQSSG LYSLSSVVTV PSSSLGTKTY TCNVDHKPSN TKVDKRVESK YGPPCPPCPA
PEFLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSQEDP EVQFNWYVDG VEVHNAKTKP
REEQFNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKGLPSS IEKTISKAKG QPREPQVYTL
PPSQEEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSRLT
VDKSRWQEGN VFSCSVMHEA LHNHYTQKSL SLSLG
(Light chain)
QSVLTQPPSA SGTPGQRVTI SCSGSSSNIG RNYVYWYQQL PGTAPKLLIY SNNQRPSGVP
DRFSGSKSGT SASLAISGLR SEDEADYYCA AWDASLRGVF GGGTKLTVLG QPKAAPSVTL
FPPSSEELQA NKATLVCLIS DFYPGAVTVA WKADSSPVKA GVETTTPSKQ SNNKYAASSY
LSLTPEQWKS HRSYSCQVTH EGSTVEKTVA PTECS
(Disulfide bridge: H22-H96, H143-L214, H156-H212, H235-H'235, H238-H'238, H270-H330, H376-H434, H'22-H'96, H'143-L'214, H'156-H'212, H'270-H'330, H'376-H'434, L22-L89, L137-L196, L'22-L'89, L'137-L'196)
  Type
Peptide
Remark
Therapeutic category: 4490
ATC code: B06AC07
Product: D12613<JP/US>
Efficacy
Bleeding suppressant, Anti-F12a antibody
  Disease
Hereditary angioedema [DS:H01006]
  Type
Monoclonal antibody
Target
F12a [CPD:C03379] [HSA:2161] [KO:K01328]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B06 OTHER HEMATOLOGICAL AGENTS
   B06A OTHER HEMATOLOGICAL AGENTS
    B06AC Drugs used in hereditary angioedema
     B06AC07 Garadacimab
      D12613  Garadacimab (INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D12613  Garadacimab (INN); Garadacimab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F12a
     D12613  Garadacimab (INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12613
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12613
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12613
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12613
Other DBs
CAS: 2162134-62-3
PubChem: 497621026
LinkDB

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