KEGG ORTHOLOGY: K01328

ORTHOLOGY: K01328

Entry

K01328                      KO

Symbol

F12

Name

coagulation factor XII (Hageman factor) [EC:3.4.21.38]

Pathway

map04610

Complement and coagulation cascades

Disease

H00941

Factor XII deficiency

H01006

Hereditary angioedema

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01328  F12; coagulation factor XII (Hageman factor)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01328  F12; coagulation factor XII (Hageman factor)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K01328  F12; coagulation factor XII (Hageman factor)
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.38  coagulation factor XIIa
     K01328  F12; coagulation factor XII (Hageman factor)
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01328  F12; coagulation factor XII (Hageman factor)
Domain-containing proteins not elsewhere classified [BR:ko04990]
Fibronectin (FN) domain-containing proteins
  Fibronectin type I domain-containing proteins
   K01328  F12; coagulation factor XII (Hageman factor)

Genes

HSA:

2161(F12)

PTR:	462304(F12)

PPS:	100995209(F12)

GGO:	101125814(F12)

PON:	100434389(F12)

PPYG:

129036315(F12)

NLE:	100586368(F12)

HMH:	116471892(F12)

SSYN:

129485976(F12)

MCC:	699875(F12)

MCF:	101925781(F12)

MTHB:

126956331

MNI:	105484051(F12)

CSAB:

103245055(F12)

CATY:

105581726(F12)

PANU:

100999329(F12)

TGE:	112626332(F12)

MLEU:

105546704(F12)

RRO:	104680459(F12)

RBB:	108544775(F12)

TFN:	117065332(F12)

PTEH:

111521616(F12)

CANG:

105515134(F12)

CJC:	100412907(F12)

SBQ:	101051215(F12)

CIMI:

108292162(F12)

ANAN:

105726832(F12)

MMUR:

105883825(F12)

LCAT:

123623454(F12)

PCOQ:

105823511(F12)

OGA:	100960869(F12)

MMU:	58992(F12)

MCAL:

110308153(F12)

MPAH:

110334054(F12)

RNO:	306761(F12)

MCOC:

116081647(F12)

ANU:	117714186(F12)

CGE:	100764143(F12)

MAUA:

101827943(F12)

PROB:

127229418(F12)

PLEU:

114689206(F12)

MORG:

121453467(F12)

MFOT:

126502886

AAMP:

119817505(F12)

NGI:	103732377(F12)

HGL:	101720589(F12)

CPOC:

100728720(F12)

CCAN:

109685737(F12)

DORD:

105985443(F12)

DSP:	122096537(F12)

PLOP:

125341958(F12)

NCAR:

124987089

MMMA:

107144723(F12)

OCU:

100351481

OPI:	101523368(F12)

TUP:	102472619(F12)

GVR:	103594909(F12)

CFA:	489090(F12)

CLUD:

112651364(F12)

VVP:	112927944(F12)

VLG:	121487275(F12)

NPO:	129509839(F12)

AML:	100475269(F12)

UMR:

103664758

UAH:	113264151(F12)

UAR:	123791509(F12)

ELK:

111141160

LLV:

125100999

MPUF:

101686585(F12)

MNP:	132028473(F12)

MLK:	131831976(F12)

NVS:	122901773(F12)

ORO:	101377877(F12)

EJU:	114208722(F12)

ZCA:	113929206(F12)

MLX:	118017315(F12)

NSU:	110588475(F12)

LWW:	102734552(F12)

FCA:	100313488(F12)

PYU:	121011726(F12)

PCOO:

112860979(F12)

PBG:	122489877(F12)

PVIV:

125169961(F12)

LRUF:

124520001

PTG:	102968089(F12)

PPAD:

109267582(F12)

PUC:

125934392

AJU:

106975412

HHV:	120236803(F12)

BTA:	280789(F12)

BOM:	102271184(F12)

BIU:	109561902(F12)

BBUB:

102411763(F12)

BBIS:

104993332(F12)

CHX:	102178999(F12)

OAS:	101106770(F12)

BTAX:

128051527(F12)

ODA:	120863853(F12)

CCAD:

122440034(F12)

MBEZ:

129559436(F12)

SSC:	397474(F12)

CFR:	102509848(F12)

CBAI:

105062036(F12)

CDK:	105099592(F12)

VPC:	102528574(F12)

BACU:

103008303(F12)

BMUS:

118892560(F12)

LVE:	103090424(F12)

OOR:	101286772(F12)

DLE:	111169857(F12)

PCAD:

102988028(F12)

PSIU:

116750993(F12)

NASI:

112400091(F12)

ECB:	100068589(F12)

EPZ:	103539971(F12)

EAI:	106827197(F12)

MYB:	102263500(F12)

MYD:	102764826(F12)

MMYO:

118657566(F12)

MLF:	102422821(F12)

MDT:	132235574(F12)

PKL:	118711279(F12)

EFUS:

103287365(F12)

MNA:	107529736(F12)

DRO:	112320387(F12)

SHON:

118999765(F12)

AJM:	119035154(F12)

PDIC:

114509956(F12)

PHAS:

123813235(F12)

MMF:	118643761(F12)

PPAM:

129066463(F12)

HAI:	109389742(F12)

RFQ:	117016472(F12)

PALE:

102877694(F12)

PGIG:

120616565(F12)

PVP:	105293507(F12)

RAY:	107517529(F12)

MJV:	108406369(F12)

TOD:	119235734(F12)

SARA:

101538105(F12)

SETR:

126012018(F12)

LAV:	100663101(F12)

TMU:

101342146

ETF:	101646298(F12)

DNM:	101431380(F12)

MDO:	100031953(F12)

GAS:	123235484(F12)

SHR:	100922168(F12)

AFZ:

127550286

PCW:	110216837(F12)

TVP:	118843051(F12)

OAA:	100087798(F12)

AMJ:	102570409(F12)

CPIC:

101953082(F12)

TST:	117882018(F12)

CABI:

116833290(F12)

MRV:	120370460(F12)

ACS:	100555717(f12)

ASAO:

132769057(F12)

PVT:	110077399(F12)

SUND:

121920360(F12)

PBI:	112540271(F12)

PMUR:

114922858(F12)

CTIG:

120304035(F12)

TSR:	106553235(F12)

PGUT:

117679805(F12)

APRI:

131191897(F12)

PTEX:

113454960(F12)

NSS:	113415808(F12)

VKO:	123034027(F12)

PMUA:

114591453(F12)

PRAF:

128408075(F12)

ZVI:	118080515(F12)

HCG:	128341619(F12)

GJA:	107111529(F12)

STOW:

125427670(F12)

EMC:	129328981(F12)

XLA:	100037012(f12.L)

XTR:	100493769(f12)

NPR:	108783741(F12)

RTEM:

120932213(F12)

BBUF:

120977540(F12)

BGAR:

122928204(F12)

MUO:	115476690(F12)

GSH:	117351817(F12)

SCHU:

PPOT:

PXU:

SLIU:

OFU:

Reference

PMID:3011063

Authors

Que BG, Davie EW

Title

Characterization of a cDNA coding for human factor XII (Hageman factor).

Journal

Biochemistry 25:1525-8 (1986)
DOI:10.1021/bi00355a009

Sequence

[hsa:2161]

Reference

PMID:21304106

Authors

MacQuarrie JL, Stafford AR, Yau JW, Leslie BA, Vu TT, Fredenburgh JC, Weitz JI

Title

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation.

Journal

Blood 117:4134-41 (2011)
DOI:10.1182/blood-2010-07-290551

LinkDB

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