KEGG   ORTHOLOGY: K01328
Entry
K01328                      KO                                     

Name
F12
Definition
coagulation factor XII (Hageman factor) [EC:3.4.21.38]
Pathway
map04610  Complement and coagulation cascades
Disease
H00941  Factor XII deficiency
H01006  Hereditary angioedema
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01328  F12; coagulation factor XII (Hageman factor)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01328  F12; coagulation factor XII (Hageman factor)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K01328  F12; coagulation factor XII (Hageman factor)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.38  coagulation factor XIIa
     K01328  F12; coagulation factor XII (Hageman factor)
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K01328  F12; coagulation factor XII (Hageman factor)
Domain-containing proteins not elsewhere classified [BR:ko04990]
 Fibronectin (FN) domain-containing proteins
  Fibronectin type I domain-containing proteins
   K01328  F12; coagulation factor XII (Hageman factor)
Genes
HSA: 2161(F12)
PTR: 462304(F12)
PPS: 100995209(F12)
GGO: 101125814(F12)
PON: 100434389(F12)
NLE: 100586368(F12)
MCC: 699875(F12)
MCF: 101925781(F12)
CSAB: 103245055(F12)
CATY: 105581726(F12)
PANU: 100999329(F12)
RRO: 104680459(F12)
RBB: 108544775(F12)
TFN: 117065332(F12)
PTEH: 111521616(F12)
CJC: 100412907(F12)
SBQ: 101051215(F12)
MMUR: 105883825(F12)
MMU: 58992(F12)
MCAL: 110308153(F12)
MPAH: 110334054(F12)
RNO: 306761(F12)
MCOC: 116081647(F12)
MUN: 110544700(F12)
CGE: 100764143(F12)
PLEU: 114689206(F12)
NGI: 103732377(F12)
HGL: 101720589(F12)
CCAN: 109685737(F12)
OCU: 100351481(F12)
TUP: 102472619(F12)
CFA: 489090(F12)
VVP: 112927944(F12)
VLG: 121487275(F12)
AML: 100475269(F12)
UMR: 103664758(F12)
UAH: 113264151(F12)
ORO: 101377877(F12)
ELK: 111141160
MPUF: 101686585(F12)
EJU: 114208722(F12)
MLX: 118017315(F12)
FCA: 100313488(F12)
PTG: 102968089(F12)
PPAD: 109267582(F12)
AJU: 106975412(F12)
HHV: 120236803(F12)
BTA: 280789(F12)
BOM: 102271184(F12)
BIU: 109561902(F12)
BBUB: 102411763(F12)
CHX: 102178999(F12)
OAS: 101106770(F12)
ODA: 120863853(F12)
SSC: 397474(F12)
CFR: 102509848(F12)
CDK: 105099592(F12)
BACU: 103008303(F12)
LVE: 103090424(F12)
OOR: 101286772(F12)
DLE: 111169857(F12)
PCAD: 102988028(F12)
ECB: 100068589(F12)
EPZ: 103539971(F12)
EAI: 106827197(F12)
MYB: 102263500(F12)
MYD: 102764826(F12)
MMYO: 118657566(F12)
MNA: 107529736(F12)
HAI: 109389742(F12)
DRO: 112320387(F12)
SHON: 118999765(F12)
AJM: 119035154(F12)
MMF: 118643761(F12)
PALE: 102877694(F12)
RAY: 107517529(F12)
MJV: 108406369(F12)
TOD: 119235734(F12)
LAV: 100663101(F12)
TMU: 101342146
MDO: 100031953(F12)
SHR: 100922168(F12)
PCW: 110216837(F12)
OAA: 100087798(F12)
AMJ: 102570409(F12)
CPIC: 101953082(F12)
TST: 117882018(F12)
CABI: 116833290(F12)
ACS: 100555717(f12)
PVT: 110077399(F12)
PBI: 112540271(F12)
PMUR: 114922858(F12)
TSR: 106553235(F12)
PGUT: 117679805(F12)
PMUA: 114591453(F12)
ZVI: 118080515(F12)
GJA: 107111529(F12)
XLA: 100037012(f12.L)
XTR: 100493769(f12)
NPR: 108783741(F12)
PPOT: 106109596
PXU: 106124100
 » show all
Reference
PMID:3011063
  Authors
Que BG, Davie EW
  Title
Characterization of a cDNA coding for human factor XII (Hageman factor).
  Journal
Biochemistry 25:1525-8 (1986)
DOI:10.1021/bi00355a009
  Sequence
[hsa:2161]
Reference
  Authors
MacQuarrie JL, Stafford AR, Yau JW, Leslie BA, Vu TT, Fredenburgh JC, Weitz JI
  Title
Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation.
  Journal
Blood 117:4134-41 (2011)
DOI:10.1182/blood-2010-07-290551
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