Homo sapiens (human): 2161 Help Entry 2161              CDS       T01001                                  Symbol F12, HAE3, HAEX, HAF Name (RefSeq) coagulation factor XII   KO K01328   coagulation factor XII (Hageman factor) [EC:3.4.21.38] Organism hsa  Homo sapiens (human) Pathway hsa04610   Complement and coagulation cascades Network nt06514  Coagulation cascade   Element N01506   Intrinsic pathway of coagulation cascade, F12 activation Disease H00941   Factor XII deficiency H01006   Hereditary angioedema Drug target Garadacimab:  D12613<JP> Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     2161 (F12)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     2161 (F12)   09183 Protein families: signaling and cellular processes    04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]     2161 (F12) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.21  Serine endopeptidases     3.4.21.38  coagulation factor XIIa      2161 (F12) Peptidases and inhibitors [BR:hsa01002]  Serine peptidases   Family S1: chymotrypsin family    2161 (F12) Domain-containing proteins not elsewhere classified [BR:hsa04990]  Fibronectin (FN) domain-containing proteins   Fibronectin type I domain-containing proteins    2161 (F12) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Trypsin Kringle fn2 EGF fn1 JAG1-like_EGF2 hEGF Trypsin_2 EGF_2 DUF1986 Motif Other DBs NCBI-GeneID:  2161 NCBI-ProteinID:  NP_000496 OMIM:  610619 HGNC:  3530 Ensembl:  ENSG00000131187 CPD:  C03379 UniProt:  P00748 Q8IZZ5 Structure PDBPDBj LinkDB All DBs Position 5:complement(177402141..177409564) Genome browser AA seq 615 aa AA seqDB search MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT DVAYYLAWIREHTVS NT seq 1848 nt NT seq  +upstreamnt  +downstreamnt atgagggctctgctgctcctggggttcctgctggtgagcttggagtcaacactttcgatt ccaccttgggaagcccccaaggagcataagtacaaagctgaagagcacacagtcgttctc actgtcaccggggagccctgccacttccccttccagtaccaccggcagctgtaccacaaa tgtacccacaagggccggccaggccctcagccctggtgtgctaccacccccaactttgat caggaccagcgatggggatactgtttggagcccaagaaagtgaaagaccactgcagcaaa cacagcccctgccagaaaggagggacctgtgtgaacatgccaagcggcccccactgtctc tgtccacaacacctcactggaaaccactgccagaaagagaagtgctttgagcctcagctt ctccggtttttccacaagaatgagatatggtatagaactgagcaagcagctgtggccaga tgccagtgcaagggtcctgatgcccactgccagcggctggccagccaggcctgccgcacc aacccgtgcctccatgggggtcgctgcctagaggtggagggccaccgcctgtgccactgc ccggtgggctacaccggagccttctgcgacgtggacaccaaggcaagctgctatgatggc cgcgggctcagctaccgcggcctggccaggaccacgctctcgggtgcgccctgtcagccg tgggcctcggaggccacctaccggaacgtgactgccgagcaagcgcggaactggggactg ggcggccacgccttctgccggaacccggacaacgacatccgcccgtggtgcttcgtgctg aaccgcgaccggctgagctgggagtactgcgacctggcacagtgccagaccccaacccag gcggcgcctccgaccccggtgtcccctaggcttcatgtcccactcatgcccgcgcagccg gcaccgccgaagcctcagcccacgacccggaccccgcctcagtcccagaccccgggagcc ttgccggcgaagcgggagcagccgccttccctgaccaggaacggcccactgagctgcggg cagcggctccgcaagagtctgtcttcgatgacccgcgtcgttggcgggctggtggcgcta cgcggggcgcacccctacatcgccgcgctgtactggggccacagtttctgcgccggcagc ctcatcgccccctgctgggtgctgacggccgctcactgcctgcaggaccggcccgcaccc gaggatctgacggtggtgctcggccaggaacgccgtaaccacagctgtgagccgtgccag acgttggccgtgcgctcctaccgcttgcacgaggccttctcgcccgtcagctaccagcac gacctggctctgttgcgccttcaggaggatgcggacggcagctgcgcgctcctgtcgcct tacgttcagccggtgtgcctgccaagcggcgccgcgcgaccctccgagaccacgctctgc caggtggccggctggggccaccagttcgagggggcggaggaatatgccagcttcctgcag gaggcgcaggtaccgttcctctccctggagcgctgctcagccccggacgtgcacggatcc tccatcctccccggcatgctctgcgcagggttcctcgagggcggcaccgatgcgtgccag ggtgattccggaggcccgctggtgtgtgaggaccaagctgcagagcgccggctcaccctg caaggcatcatcagctggggatcgggctgtggtgaccgcaacaagccaggcgtctacacc gatgtggcctactacctggcctggatccgggagcacaccgtttcctga

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