KEGG   DRUG: Frexalimab
Entry
D12620                      Drug                                   
Name
Frexalimab (USAN/INN)
Formula
C6492H9964N1704O2030S40
Exact mass
145555.7662
Mol weight
145645.44
Sequence
(Heavy chain)
EVQLQESGPG LVKPSETLSL TCTVSGDSIT NGFWIWIRKP PGNKLEYMGY ISYSGSTYYN
PSLKSRISIS RDTSKNQFSL KLSSVTAADT GVYYCAYRSY GRTPYYFDYW GQGTTLTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKAEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HRDPEVKFNW YVDGVEVHNA KTKPREEQYN
STYRVVSVLT VLHQDWLNGK EYKCAVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK
(Light chain)
DIVMTQSPSF LSASVGDRVT ITCKASSNLG HAVAWYQQKP GKSPKLLIYS ASNRYTGVPD
RFSGSGSGTD FTLTISSLQP EDFADYFCQQ YDDYPYTFGG GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide birdge: H22-H95, H223-L214, H147-H203, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'95, H'223-L'214, H'147-H'203, H'264-H'324, H'370-H'428, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Immunomodulator, Anti-CD40 ligand antibody
  Type
Monoclonal antibody
Comment
Treatment of autoimmune and neurologic diseases
Target
TNFSF5 (CD154) [HSA:959] [KO:K03161]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF5 (CD154)
     D12620  Frexalimab (USAN/INN)
Other DBs
CAS: 2515463-86-0
PubChem: 497621033
LinkDB

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