KEGG ORTHOLOGY: K03161

ORTHOLOGY: K03161

Entry

K03161                      KO

Symbol

TNFSF5, CD40L, CD154

Name

tumor necrosis factor ligand superfamily member 5

Pathway

map04060

Cytokine-cytokine receptor interaction

map04064

NF-kappa B signaling pathway

map04514

Cell adhesion molecules

map04660

T cell receptor signaling pathway

map04672

Intestinal immune network for IgA production

map05144

Malaria

map05145

Toxoplasmosis

map05310

Asthma

map05320

Autoimmune thyroid disease

map05322

Systemic lupus erythematosus

map05330

Allograft rejection

map05340

Primary immunodeficiency

map05416

Viral myocarditis

map05417

Lipid and atherosclerosis

Disease

H00086

Immunodeficiency with hyper-IgM

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   04514 Cell adhesion molecules
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   04672 Intestinal immune network for IgA production
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
09160 Human Diseases
  09174 Infectious disease: parasitic
   05144 Malaria
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   05145 Toxoplasmosis
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
  09163 Immune disease
   05310 Asthma
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   05322 Systemic lupus erythematosus
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   05320 Autoimmune thyroid disease
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   05330 Allograft rejection
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   05340 Primary immunodeficiency
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   05416 Viral myocarditis
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
   04090 CD molecules
    K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Tumor necrosis fators
   K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
CD molecules [BR:ko04090]
Proteins
  K03161  CD154, CD40LG; tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)

Other DBs

GO:	0005174 0005164

Genes

HSA:	959(CD40LG)

PTR:	473802(CD40LG)

PPS:	100975410(CD40LG)

GGO:	101152672(CD40LG)

PON:	100434130(CD40LG)

PPYG:

129024945(CD40LG)

NLE:	100594974(CD40LG)

HMH:	116812081(CD40LG)

SSYN:

129476314(CD40LG)

MCC:	574160(CD40LG)

MCF:	102138630(CD40LG)

MTHB:

126946644

MNI:	105481370(CD40LG)

CSAB:

103232640(CD40LG)

CATY:

105592681(CD40LG)

PANU:

101011100(CD40LG)

TGE:	112615960(CD40LG)

MLEU:

105549761(CD40LG)

RRO:	104682444(CD40LG)

RBB:	108542673(CD40LG)

TFN:	117078169(CD40LG)

PTEH:

111531588(CD40LG)

CANG:

105516531(CD40LG)

CJC:	100390012(CD40LG)

SBQ:	101051030(CD40LG)

CIMI:

108292985(CD40LG)

ANAN:

105730852(CD40LG)

CSYR:

103272733(CD40LG)

MMUR:

105866775(CD40LG)

LCAT:

123628863(CD40LG)

PCOQ:

105819267(CD40LG)

OGA:	100964652(CD40LG)

MMU:	21947(Cd40lg)

MCAL:

110287416(Cd40lg)

MPAH:

110314146(Cd40lg)

RNO:	84349(Cd40lg)

MCOC:

116092757(Cd40lg)

ANU:	117695305(Cd40lg)

MUN:	110561796(Cd40lg)

CGE:	100763089(Cd40lg)

MAUA:

101834854(Cd40lg)

PROB:

127217837(Cd40lg)

PLEU:

114707230(Cd40lg)

MORG:

121437366 121437564

MFOT:

126512121

AAMP:

119805423(Cd40lg)

NGI:	103740147(Cd40lg)

HGL:	101700616(Cd40lg)

CPOC:

100733664(Cd40lg)

CCAN:

109681519(Cd40lg)

DORD:

105986972(Cd40lg)

DSP:	122097106(Cd40lg)

PLOP:

125343633(Cd40lg)

NCAR:

124972262

MMMA:

107152535(Cd40lg)

OCU:	100358388(CD40LG)

OPI:	101526084(CD40LG)

TUP:	102488619(CD40LG)

GVR:	103607164(CD40LG)

CFA:	403468(CD40LG)

CLUD:

112668490(CD40LG)

VVP:	112911361(CD40LG)

VLG:	121483177(CD40LG)

NPO:	129518821(CD40LG)

AML:	100467917(CD40LG)

UMR:	103672841(CD40LG)

UAH:	113241871(CD40LG)

UAR:	123787604(CD40LG)

ELK:

111139351

LLV:

125092458

MPUF:

101681499(CD40LG)

MNP:	132007873(CD40LG)

MLK:	131821750(CD40LG)

NVS:	122897035(CD40LG)

ORO:	101382563(CD40LG)

EJU:	114201455(CD40LG)

ZCA:	113931071(CD40LG)

MLX:	118011682(CD40LG)

NSU:	110575677(CD40LG)

LWW:	102732111(CD40LG)

FCA:	493850(CD40LG)

PYU:	121025809(CD40LG)

PCOO:

112871198(CD40LG)

PBG:	122477353(CD40LG)

PVIV:

125156928(CD40LG)

LRUF:

124513966

PTG:	102969350(CD40LG)

PPAD:

109250461(CD40LG)

PUC:

125932008

AJU:

106985488

HHV:	120220140(CD40LG)

BTA:	112445051 282387(CD40LG)

BOM:	102269787(CD40LG)

BIU:	109555532(CD40LG)

BBUB:

102398646(CD40LG)

BBIS:

104998211(CD40LG)

CHX:	102172335(CD40LG)

OAS:	767628(CD40LG)

BTAX:

128070488(CD40LG)

ODA:	120882294(CD40LG)

CCAD:

122436029(CD40LG)

MBEZ:

129534816(CD40LG)

SSC:	397231(CD40LG)

CFR:	102520018(CD40LG)

CBAI:

105067053(CD40LG)

CDK:	105101647(CD40LG)

VPC:	102531240(CD40LG)

BACU:

103011748(CD40LG)

BMUS:

118888781(CD40LG)

LVE:	103070177(CD40LG)

OOR:	101274859(CD40LG)

DLE:	111164543(CD40LG)

PCAD:

102974041(CD40LG)

PSIU:

116748020(CD40LG)

NASI:

112409789(CD40LG)

ECB:	100054624(CD40LG)

EPZ:	103541553(CD40LG)

EAI:	106825790(CD40LG)

MYB:	102255985(CD40LG)

MYD:	102762217(CD40LG)

MMYO:

118654764(CD40LG)

MLF:	102433204(CD40LG)

MDT:	132223899(CD40LG)

PKL:	118722067(CD40LG)

EFUS:

103302105(CD40LG)

MNA:	107539933(CD40LG)

DRO:	112307303(CD40LG)

SHON:

118998089(CD40LG)

AJM:	119058100(CD40LG)

PDIC:

114505126(CD40LG)

PHAS:

123819099(CD40LG)

MMF:	118636408(CD40LG)

PPAM:

129075429(CD40LG)

HAI:	109396161(CD40LG)

RFQ:	117031705(CD40LG)

PALE:

102885468(CD40LG)

PGIG:

120612438(CD40LG)

PVP:	105307045(CD40LG)

RAY:	107501399(CD40LG)

MJV:	108410086(CD40LG)

TOD:	119246511(CD40LG)

SARA:

101552082(CD40LG)

SETR:

125998595(CD40LG)

LAV:	100659000(CD40LG)

TMU:

101354525

ETF:	101653603(CD40LG)

DNM:	101426835(CD40LG)

MDO:	100010217(CD40LG)

GAS:	123253558(CD40LG)

SHR:	100918070(CD40LG)

AFZ:

127542334

PCW:	110197721(CD40LG)

TVP:	118832895(CD40LG)

OAA:	100083615(CD40LG)

GGA:	395485(CD40LG)

PCOC:

116229645(CD40LG)

MGP:	100546658(CD40LG)

CJO:	107312660(CD40LG)

TPAI:

128076070(CD40LG)

LMUT:

125699697(CD40LG)

NMEL:

110403205(CD40LG)

APLA:

101789598(CD40LG)

ACYG:

106037482(CD40LG)

CATA:

118245502(CD40LG)

AFUL:

116494586(CD40LG)

TGU:	100231712(CD40LG)

LSR:	110476868(CD40LG)

SCAN:

103816467(CD40LG)

PMOA:

120508770(CD40LG)

OTC:	121331838(CD40LG)

PRUF:

121349131(CD40LG)

GFR:	102031951(CD40LG)

FAB:	101808143(CD40LG)

OMA:	130253066(CD40LG)

PHI:	102107724(CD40LG)

PMAJ:

107203830(CD40LG)

CCAE:

111928529(CD40LG)

CCW:	104691326(CD40LG)

CBRC:

103622440(CD40LG)

ETL:	114065822(CD40LG)

ZAB:	102060663(CD40LG)

ZLE:	135447780(CD40LG)

ACHL:

103811554(CD40LG)

SVG:	106858386(CD40LG)

MMEA:

130584755(CD40LG)

HRT:	120764982(CD40LG)

SATI:

136373274 136374481(CD40LG)

FPG:	101911204(CD40LG)

FCH:	102059509(CD40LG)

CCRI:

104163798(CD40LG)

NNT:	104405584(CD40LG)

SHAB:

115612769(CD40LG)

ACUN:

113480245(CD40LG)

TALA:

104364131(CD40LG)

ACHC:

115333939(CD40LG)

HALD:

104315217(CD40LG)

HLE:	104834828(CD40LG)

AGEN:

126050259

GCL:

127019745

CSTI:

104561371(CD40LG)

LDI:	104352123(CD40LG)

MNB:

103778905

DPUB:

104303615(CD40LG)

AVIT:

104276933(CD40LG)

BRHI:

104492553(CD40LG)

EGZ:	104130245(CD40LG)

NNI:	104012871(CD40LG)

PCRI:

104035704(CD40LG)

PCAO:

104050620(CD40LG)

PADL:

103923375(CD40LG)

AFOR:

103905807(CD40LG)

FGA:	104077747(CD40LG)

GSTE:

104262003(CD40LG)

CLV:	102086646(CD40LG)

MUI:	104541494(CD40LG)

PGUU:

104470541(CD40LG)

PLET:

104626730(CD40LG)

EHS:	104508411(CD40LG)

CMAC:

104479347(CD40LG)

CUCA:

104060677(CD40LG)

TEO:	104371727(CD40LG)

BREG:

104636320(CD40LG)

OHA:	104335687(CD40LG)

ACAR:

104528647(CD40LG)

CPEA:

104388385(CD40LG)

CVF:	104283520(CD40LG)

RTD:	128914530(CD40LG)

AAM:

106492266

AROW:

112974116(CD40LG)

NPD:	112944544(CD40LG)

TGT:	104579004(CD40LG)

DNE:	112989703(CD40LG)

SCAM:

104150560(CD40LG)

ASN:	102381504(CD40LG)

AMJ:	102575281(CD40LG)

CPOO:

109311015(CD40LG)

GGN:	109300608(CD40LG)

PSS:	102447555(CD40LG)

CMY:	102945133(CD40LG)

CPIC:

101936275(CD40LG)

TST:	117883353(CD40LG)

CABI:

116820588(CD40LG)

MRV:	120371362(CD40LG)

ACS:	100556739(cd40lg)

ASAO:

132763070(CD40LG)

PVT:	110088171(CD40LG)

SUND:

121937142(CD40LG)

PBI:	103063026(CD40LG)

PMUR:

107303226(CD40LG)

CTIG:

120313166(CD40LG)

TSR:

106551866

PGUT:

117679558(CD40LG)

APRI:

131183880(CD40LG)

PTEX:

113446774(CD40LG)

VKO:	123034986(CD40LG)

PMUA:

114589510(CD40LG)

PRAF:

128406181(CD40LG)

ZVI:	118083815(CD40LG)

HCG:	128335656(CD40LG)

GJA:	107121162(CD40LG)

STOW:

125442451(CD40LG)

EMC:	129341522(CD40LG)

XLA:	108698921(cd40lg.L) 108700557(cd40lg.S)

XTR:	100489038(cd40lg)

NPR:	108785871(CD40LG)

RTEM:

120914566(CD40LG)

BBUF:

120977602(CD40LG)

BGAR:

122919670(CD40LG)

MUO:	115474488(CD40LG)

GSH:	117352488(CD40LG)

DRE:	793819(cd40lg)

SRX:	107744511 107752084

SANH:

107658100 107661434

SGH:	107561553 107601131

CCAR:

109049094 109054254

CAUA:

113058163 113113970

CGIB:

127971813 128027251

PTET:

122357394(cd40lg)

LROH:

127175805(cd40lg)

OMC:	131552893(cd40lg)

PPRM:

120475033(cd40lg)

RKG:	130077207(cd40lg)

MAMB:

125259378(cd40lg)

CIDE:

127494539

CERY:

137020779(cd40lg)

MASI:

127413262 127418273

TROS:

130563507(cd40lg)

TDW:	130438258(cd40lg)

MANU:

129422695(cd40lg)

IPU:

108268440

IFU:	128611222(cd40lg)

PHYP:

113529243(cd40lg)

SMEO:

124386087(cd40lg)

TFD:	113635687(cd40lg)

TVC:	132855833(cd40lg)

TRN:	134319669(cd40lg)

CMAO:

118806464(cd40lg)

EEE:

113583054

CHAR:

105911302(cd40lg)

SASA:

100286596(cd40l) 106604808

OTW:	112220630 112257086

OMY:	100136698(cd40l) 110488745

SALP:

111965656 111966998

ELS:

105028611

SFM:	108922988 108928895(cd40lg)

PKI:	111834994 111860552

AANG:

118224259 118235443

LOC:	102698143(cd40lg)

PSPA:

121295716 121317922

ARUT:

117412130 117430543

LCM:	102357754(CD40LG)

CMK:

RTP:

CPLA:

HOC:

LERI:

GAE:	121388091 121388436 121388442 121388649

HRF:

124124666

HRJ:	124266024 124268957 124282370

MYI:

110441632

PMAX:

117342352

MMER:

123554527 123554528 123554552 123554569

RPHI:

132714854 132760207

» show all

Reference

PMID:1280226

Authors

Graf D, Korthauer U, Mages HW, Senger G, Kroczek RA

Title

Cloning of TRAP, a ligand for CD40 on human T cells.

Journal

Eur J Immunol 22:3191-4 (1992)
DOI:10.1002/eji.1830221226

Sequence

[hsa:959]

Reference

PMID:15193700

Authors

Furman MI, Krueger LA, Linden MD, Barnard MR, Frelinger AL 3rd, Michelson AD

Title

Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization.

Journal

J Am Coll Cardiol 43:2319-25 (2004)
DOI:10.1016/j.jacc.2003.12.055

Sequence

[hsa:959]

LinkDB

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