KEGG   DRUG: Vonoprazan and amoxicillin
Entry
D12756            Mixture   Drug                                   
Name
Vonoprazan and amoxicillin;
Voquezna (TN)
Product
VONOPRAZAN FUMARATE AND AMOXICILLIN (Phathom Pharmaceuticals)
Component
Margetuximab [DR:D10446], Amoxicillin [DR:D00229]
Class
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
Product: D12756<US>
Efficacy
Antibacterial
  Disease
Helicobacter pylori infection [DS:H00320]
Comment
Vonoprazan is metabolized by CYP3A4/5, CYP2B6, CYP2C19, CYP2C9 and CYP2D6.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP2B6 [HSA:1555], CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP2D6 [HSA:1565]
Interaction
Brite
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Amoxicillin/ Vonoprazan
    D12756  Vonoprazan and amoxicillin
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D12756  Vonoprazan and amoxicillin
  DG01642  CYP2C9 substrate
   D12756  Vonoprazan and amoxicillin
  DG01639  CYP2C19 substrate
   D12756  Vonoprazan and amoxicillin
  DG01644  CYP2D6 substrate
   D12756  Vonoprazan and amoxicillin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D12756  Vonoprazan and amoxicillin
  DG02925  CYP3A5 substrate
   D12756  Vonoprazan and amoxicillin
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Combination for eradication of H. pylori
    D12756  Vonoprazan and amoxicillin <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12756
LinkDB

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