KEGG   DRUG: Navenibart
Entry
D12770                      Drug                                   
Name
Navenibart (USAN)
Formula
C6474H9956N1708O2022S44
Exact mass
145387.6449
Mol weight
145477.49
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYAFS SYWMNWVRQA PGQGLEWIGQ IYPGDDDTNY
NAKFQGRVTI TVDKSTTTAY MELSSLRSED TAVYFCAGSL MVTTGAPFDY WGQGTTVTVS
SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKRVE PKSCDKTHTC PPCPAPELLG
GPSVFLFPPK PKDTLYITRE PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE
EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCKASQDVG IAVAWYQQKP GKAPKFLIYY ASHRGWGVPD
RFSGSGSGTD FTLTISSLQP EDFATYFCQQ YRSYPLTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H148-H204, H224-L214, H230-H'230, H233-H'233, H265-H325, H371-H429, H'22-H'96, H'148-H'204, H'224-L'214, H'265-H'325, H'371-H'429, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antiangioedema
  Type
Monoclonal antibody
Comment
Treatment of hereditary angioedema (HAE) in adults and pediatric patients
Target
KLKB1 [HSA:3818] [KO:K01324]
  Pathway
hsa04610  Complement and coagulation cascades
Brite
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    KLKB1
     D12770  Navenibart (USAN)
Other DBs
CAS: 2803430-16-0
PubChem: 497621183
LinkDB

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