KEGG   DRUG: Zaltenibart
Entry
D12920                      Drug                                   
Name
Zaltenibart (USAN/INN)
Formula
C6406H9940N1700O2022S40
Exact mass
144315.6068
Mol weight
144404.32
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT GKWIEWVRQA PGQGLEWIGE ILPGTGSTNY
NEKFKGRATF TADSSTSTAY MELSSLRSED TAVYYCLRSE DVWGQGTLVT VSSASTKGPS
VFPLAPCSRS TSESTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS
VVTVPSSSLG TKTYTCNVDH KPSNTKVDKR VESKYGPPCP PCPAPEFLGG PSVFLFPPKP
KDTLMISRTP EVTCVVVDVS QEDPEVQFNW YVDGVEVHNA KTKPREEQFN STYRVVSVLT
VLHQDWLNGK EYKCKVSNKG LPSSIEKTIS KAKGQPREPQ VYTLPPSQEE MTKNQVSLTC
LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SRLTVDKSRW QEGNVFSCSV
LHEALHSHYT QKSLSLSLGK
(Light chain)
DIVMTQSPDS LAVSLGERAT INCKSSQSLL ASRTRKNYLA WYQQKPGQPP KLLIYWASTR
ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCKQSYNI PTFGQGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H127-L219, H140-H196, H219-H'219, H222-H'222, H254-H314, H360-H418, H'22-H'96, H'127-L'219, H'140-H'196, H'254-H'314, H'360-H'418, L23-L94, L139-L199, L'23-L'94, L'139-L'199)
  Type
Peptide
Efficacy
Complement cascade inhibitor
  Type
Monoclonal antibody
Comment
Treatment of paroxysmal nocturnal hemoglobinuria (PNH)
Target
MASP1 (MASP-3) [HSA:5648] [KO:K03992]
  Pathway
hsa04610  Complement and coagulation cascades
Brite
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    MASP1 (MASP-3)
     D12920  Zaltenibart (USAN/INN)
Other DBs
CAS: 2527079-60-1
PubChem: 497621333
LinkDB

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