KEGG   Homo sapiens (human): 5648
Entry
5648              CDS       T01001                                 
Symbol
MASP1, 3MC1, CRARF, CRARF1, MAP-1, MAP1, MASP, MASP-3, MASP3, MAp44, PRSS5, RaRF
Name
(RefSeq) MBL associated serine protease 1
  KO
K03992  mannan-binding lectin serine protease 1 [EC:3.4.21.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06136  Complement activation (viruses)
nt06171  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  Element
N01311  Lectin pathway of complement activation
N01312  SARS-CoV-2 S to lectin pathway of complement activation
N01315  Lectin pathway of coagulation activation
N01316  SARS-CoV-2 S/N to lectin pathway of coagulation activation
Disease
H01887  3MC syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5648 (MASP1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    5648 (MASP1)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    5648 (MASP1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5648 (MASP1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.-
     5648 (MASP1)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   5648 (MASP1)
SSDB
Motif
Pfam: Trypsin CUB Sushi FXa_inhibition EGF_CA cEGF Trypsin_2 Peptidase_S6 DUF1986
Other DBs
NCBI-GeneID: 5648
NCBI-ProteinID: NP_001870
OMIM: 600521
HGNC: 6901
Ensembl: ENSG00000127241
Vega: OTTHUMG00000156461
Pharos: P48740(Tbio)
UniProt: P48740
Structure
LinkDB
Position
3:complement(187217282..187291737)
AA seq 699 aa
MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL
GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL
HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET
LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW
YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN
NT seq 2100 nt   +upstreamnt  +downstreamnt
atgaggtggctgcttctctattatgctctgtgcttctccctgtcaaaggcttcagcccac
accgtggagctaaacaatatgtttggccagatccagtcgcctggttatccagactcctat
cccagtgattcagaggtgacttggaatatcactgtcccagatgggtttcggatcaagctt
tacttcatgcacttcaacttggaatcctcctacctttgtgaatatgactatgtgaaggta
gaaactgaggaccaggtgctggcaaccttctgtggcagggagaccacagacacagagcag
actcccggccaggaggtggtcctctcccctggctccttcatgtccatcactttccggtca
gatttctccaatgaggagcgtttcacaggctttgatgcccactacatggctgtggatgtg
gacgagtgcaaggagagggaggacgaggagctgtcctgtgaccactactgccacaactac
attggcggctactactgctcctgccgcttcggctacatcctccacacagacaacaggacc
tgccgagtggagtgcagtgacaacctcttcactcaaaggactggggtgatcaccagccct
gacttcccaaacccttaccccaagagctctgaatgcctgtataccatcgagctggaggag
ggtttcatggtcaacctgcagtttgaggacatatttgacattgaggaccatcctgaggtg
ccctgcccctatgactacatcaagatcaaagttggtccaaaagttttggggcctttctgt
ggagagaaagccccagaacccatcagcacccagagccacagtgtcctgatcctgttccat
agtgacaactcgggagagaaccggggctggaggctctcatacagggctgcaggaaatgag
tgcccagagctacagcctcctgtccatgggaaaatcgagccctcccaagccaagtatttc
ttcaaagaccaagtgctcgtcagctgtgacacaggctacaaagtgctgaaggataatgtg
gagatggacacattccagattgagtgtctgaaggatgggacgtggagtaacaagattccc
acctgtaaaattgtagactgtagagccccaggagagctggaacacgggctgatcaccttc
tctacaaggaacaacctcaccacatacaagtctgagatcaaatactcctgtcaggagccc
tattacaagatgctcaacaataacacaggtatatatacctgttctgcccaaggagtctgg
atgaataaagtattggggagaagcctacccacctgccttccagtgtgtgggctccccaag
ttctcccggaagctgatggccaggatcttcaatggacgcccagcccagaaaggcaccact
ccctggattgccatgctgtcacacctgaatgggcagcccttctgcggaggctcccttcta
ggctccagctggatcgtgaccgccgcacactgcctccaccagtcactcgatccggaagat
ccgaccctacgtgattcagacttgctcagcccttctgacttcaaaatcatcctgggcaag
cattggaggctccggtcagatgaaaatgaacagcatctcggcgtcaaacacaccactctc
cacccccagtatgatcccaacacattcgagaatgacgtggctctggtggagctgttggag
agcccagtgctgaatgccttcgtgatgcccatctgtctgcctgagggaccccagcaggaa
ggagccatggtcatcgtcagcggctgggggaagcagttcttgcaaaggttcccagagacc
ctgatggagattgaaatcccgattgttgaccacagcacctgccagaaggcttatgccccg
ctgaagaagaaagtgaccagggacatgatctgtgctggggagaaggaagggggaaaggac
gcctgtgcgggtgactctggaggccccatggtgaccctgaatagagaaagaggccagtgg
tacctggtgggcactgtgtcctggggtgatgactgtgggaagaaggaccgctacggagta
tactcttacatccaccacaacaaggactggatccagagggtcaccggagtgaggaactga

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