KEGG   DRUG: Tilrekimig
Entry
D12962                      Drug                                   
Name
Tilrekimig (USAN)
Formula
C8570H13217N2293O2698S57
Exact mass
193246.1598
Mol weight
193365.19
Sequence
(A chain)
DIQMTQSPSS LSASVGDRVT ITCKASESVD HFGWSLVHWY QQKPGKAPKL LIYRASNLES
GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQQSNEDPW TFGGGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGECGG GGSEVTLRES GPALVKPTQT
LTLTCTFSGF SLSNFGEGLS WIRQPPGKGL EWLAHIYWDD DKRYNPSLKS RLTISKDTSR
NQVVLTMTNM DPVDTATYYC ARRETVFYWY FDVWGQGTTV TVSSASTKGP SVFPLAPSSK
STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV LQSSGLYSLS SVVTVPSSSL
GTQTYICNVN HKPSNTKVDK KVEPKSCEKT HTCPPCPAPE AAGAPSVFLF PPKPKDTLMI
SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW
LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SREEMTKNQV SLTCEVKGFY
PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVLHEALH
SHYTQKSLSL SPGK
(B chain)
QMQLVESGGG VVQPGRSLRL SCAASGFTFR TYGMHWVRQA PGKGLEWVAV IWYDGSNKHY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARAP QWYLVHEAFD IWGQGTMVTV
SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKKV EPKSCRKTHT CPPCPAPEAA
GAPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ
YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR
EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSRLTVDKS
RWQQGNVFSC SVLHEALHSH YTQKSLSLSP GK
(C chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVAS ISSGDTTYYP
DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCARNEG YYFGLTLWGQ GTLVTVSSAS
TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS C
(D chain)
DIQMTQSPSS LSASVGDRVT ITCRASQSVD EEGDSYMNWY QQKPGKAPKL LIYAASNLES
GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQQSNKDPP TFGGGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(E chain)
SYVLTQPPSV SVAPGQTARI TCGGNNLGSK SVHWYQQKPG QAPVLVVYDD KDRPSWIPER
FSGSNSGNTA TLTISRGEAG DEADYYCQVW DSKSDHVVFG GGTKLTVLGQ PKAAPSVTLF
PPSSEELQAN KATLVCLISD FYPGAVTVAW KADSSPVKAG VETTTPSKQS NNKYAASSYL
SLTPEQWKSH RSYSCQVTHE GSTVEKTVAP TECS
(Disulfide bridge: A23-A92, A138-A198, A218-C221, A245-A320, A371-A427, A447-D218, A488-A548, A594-A652, A453-B231, A456-B234, B22-B96, B225-E213, B266-B326, B372-B430, C22-C95, C145-C201, D23-D92, D138-D198, E22-E87, E136-E195)
  Type
Peptide
Efficacy
Anti-inflammatory
  Type
Multispecific antibody
Comment
Treatment of atopic dermatitis and other immune/ inflammatory conditions
Target
IL13 [HSA:3596] [KO:K05435]
IL4 [HSA:3565] [KO:K05430]
TSLP [HSA:85480] [KO:K05436]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL4
     D12962  Tilrekimig (USAN)
    IL13
     D12962  Tilrekimig (USAN)
   CSF and other factors
    TSLP
     D12962  Tilrekimig (USAN)
Other DBs
CAS: 2981469-90-1
PubChem: 503268982
LinkDB

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