KEGG   DRUG: Daraxonrasib
Entry
D13265                      Drug                                   
Name
Daraxonrasib (USAN/INN);
Rasonque (TN)
Product
RASONQUE (Revolution Medicines)
Formula
C44H58N8O5S
Exact mass
810.4251
Mol weight
811.05
Structure
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Product: D13265<US>
Efficacy
Antineoplastic
  Disease
Pancreatic adenocarcinoma [DS:H00019]
Comment
Treatment of patients with advanced solid tumors harboring RAS mutations
Target
KRAS [HSA:3845] [KO:K07827]
KRAS* [HSA_VAR:3845v1] [HSA:3845] [KO:K07827]
  Pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D13265  Daraxonrasib
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Environmental information processing
   G protein
    KRAS
     D13265  Daraxonrasib (USAN/INN) <US>
    KRAS* [HSA_VAR:3845v1]
     D13265  Daraxonrasib (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D13265
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D13265
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D13265
Other DBs
CAS: 2765081-21-6
PubChem: 527701168
LinkDB
KCF data

ATOM        58
            1   C1x C    23.1700  -14.8400
            2   C8y C    12.7400  -17.9900
            3   C8y C    12.7400  -19.3900
            4   C8x C    13.9300  -20.0900
            5   C8x C    15.1900  -19.3900
            6   C8y C    15.1900  -17.9900
            7   C8x C    13.9300  -17.2900
            8   C8y C    11.4100  -17.5700
            9   C8y C    10.5700  -18.6900
            10  N4y N    11.4100  -19.8100
            11  C8y C     9.1700  -18.6900
            12  C8x C     8.4700  -17.5000
            13  C8y C     7.0700  -17.5000
            14  C8x C     6.3700  -18.6900
            15  N5x N     7.0700  -19.8800
            16  C8y C     8.4700  -19.8800
            17  C1c C     9.1700  -21.0700
            18  C1a C    10.5700  -21.0700
            19  O2a O     8.4700  -22.2600
            20  C1a C     7.0700  -22.2600
            21  N1y N     6.3700  -16.3100
            22  C1x C     7.0700  -15.1200
            23  C1x C     6.3700  -13.8600
            24  N1y N     4.9700  -13.8600
            25  C1x C     4.2700  -15.0500
            26  C1x C     4.9700  -16.3100
            27  C1a C     4.2700  -12.6700
            28  C8y C    17.5700  -15.1900
            29  C1x C    17.5700  -13.7900
            30  C1y C    18.7600  -13.0900
            31  C5x C    18.7600  -11.6900
            32  O5x O    19.9500  -10.9900
            33  N1y N    17.5700  -10.9900
            34  C1x C    17.5700   -9.5900
            35  C1x C    16.3100   -8.8900
            36  C1x C    15.1200   -9.5900
            37  C1y C    15.1200  -10.9900
            38  N1x N    16.3100  -11.6900
            39  C7x C    13.9300  -11.6900
            40  O6a O    12.7400  -10.9900
            41  O7x O    13.9300  -13.0900
            42  C1x C    12.7400  -13.7900
            43  C1z C    12.7400  -15.1900
            44  C1x C    11.4100  -15.8900
            45  C1a C    12.7400  -16.5900
            46  C1a C    14.1400  -15.1900
            47  N1b N    19.9500  -13.7900
            48  C5a C    21.1400  -13.0900
            49  O5a O    21.1400  -11.6900
            50  C1b C    11.4100  -21.2100
            51  C1a C    12.6000  -21.9100
            52  N5x N    16.2400  -15.6100
            53  C8y C    16.2400  -17.0100
            54  C8x C    17.5700  -17.4300
            55  S2x S    18.4100  -16.3100
            56  C1y C    22.3300  -13.7900
            57  C1y C    23.7300  -13.7900
            58  C1a C    24.9200  -13.0900
BOND        65
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     8   9 2
            9     9  10 1
            10    3  10 1
            11    9  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   19  20 1
            22   13  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   21  26 1
            29   24  27 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   31  32 2
            34   31  33 1
            35   33  34 1
            36   34  35 1
            37   35  36 1
            38   36  37 1
            39   37  38 1
            40   33  38 1
            41   37  39 1
            42   39  40 2
            43   39  41 1
            44   41  42 1
            45   42  43 1
            46   43  44 1
            47   44   8 1
            48   43  45 1
            49   43  46 1
            50   30  47 1 #Up
            51   47  48 1
            52   48  49 2
            53   10  50 1
            54   50  51 1
            55   52  53 1
            56   53  54 2
            57   54  55 1
            58   55  28 1
            59   52  28 2
            60   53   6 1
            61   48  56 1
            62   56  57 1
            63    1  56 1
            64   57   1 1
            65   58  57 1

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