KEGG   VARIANT: 3845v1
Entry
3845v1                      Variant                                
Name
KRAS mutation
Gene
KRAS  KRAS proto-oncogene, GTPase [KO:K07827]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation G12D
ClinVar: 12582
dbSNP: rs121913529
COSM: 521
Variation
mutation G12V
ClinVar: 12583
dbSNP: rs121913529
COSM: 520
Variation
mutation G13D
ClinVar: 12580
dbSNP: rs112445441
COSM: 532
Variation
mutation G12C
ClinVar: 12578
dbSNP: rs121913530
COSM: 516
Network
nt06210  ERK signaling
nt06213  Other RAS signaling
nt06214  PI3K signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
  Element
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00104  Mutation-activated KRAS to RalGDS signaling pathway
N10027  KRAS mutation inhibitor
Drug target
Adagrasib: D12301
Sotorasib: D12055<JP/US>
Reference
  Authors
Prior IA, Lewis PD, Mattos C
  Title
A comprehensive survey of Ras mutations in cancer.
  Journal
Cancer Res 72:2457-67 (2012)
DOI:10.1158/0008-5472.CAN-11-2612
Reference
  Authors
Bowen DT, Frew ME, Hills R, Gale RE, Wheatley K, Groves MJ, Langabeer SE, Kottaridis PD, Moorman AV, Burnett AK, Linch DC
  Title
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.
  Journal
Blood 106:2113-9 (2005)
DOI:10.1182/blood-2005-03-0867
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