KEGG GLYCAN: G00093

GLYCAN: G00093

Entry

G00093                      Glycan

Name

Globotriaosylceramide;
Gb3Cer;
Pk antigen;
CD77

Composition

(Gal)2 (Glc)1 (Cer)1

Mass

486.4 (Cer)

Structure

Remark

Same as:

C04737

Reaction

R05960 R05961 R05962 R05963

Pathway

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

map01100

Metabolic pathways

Module

M00068

Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer

Enzyme

2.4.1.79 2.4.1.228 3.2.1.22 3.2.1.52

Orthology

K00719

galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]

K01189

alpha-galactosidase [EC:3.2.1.22]

K01207

beta-N-acetylhexosaminidase [EC:3.2.1.52]

K01988

lactosylceramide 4-alpha-galactosyltransferase [EC:2.4.1.228]

Brite

CD molecules [BR:ko04090]
Carbohydrates
  G00093  CD77; ceramide trihexoside
Lipids [BR:br08002]
SP  Sphingolipids
  SP05 Neutral glycosphingolipids
   SP0502 Galalpha1-4Galbeta1-4Glc- (Globo series)
    G00093  Gal-alpha1->4Gal-beta1->4Glc-beta1->1'Cer (Gb3Cer)

Reference

1 [PMID:12227795]

Authors

Bosse F, Marcaurelle LA, Seeberger PH.

Title

Linear synthesis of the tumor-associated carbohydrate antigens Globo-H, SSEA-3, and Gb3.

Journal

J Org Chem 67:6659-70 (2002)
DOI:10.1021/jo025834+

Reference

2 [PMID:2960671]

Authors

Holmes EH, Hakomori S, Ostrander GK.

Title

Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.

Journal

J Biol Chem 262:15649-58 (1987)

Other DBs

CCSD:

291 293 2404 3587 4651 4778 5723 6241 7333 8268 9933 9987 10297 10299 10869 11331 11641 11801 12378 14423 15149 15503 15548 15725 15925 16227 16330 16353 16403 16460 16868 17111 17680 17708 17928 18494 18545 18587 18633 18971 19298 21064 21142 21348 21363 21369 22111 23006 23163 23388 23853 23876 23918 24085 24122 24354 24435 24650 24766 25040 25302 25306 25315 25321 25330 25520 25546 25555 25581 25794 25820 25981 26179 26267 26597 26605 26614 26736 27232 27273 27542 27632 28502 29096 29266 29958 30834 31630 31690 31941 31985 32048 32591 32623 32730 32737 32740 33185 33204 33207 33213 33715 33899 33971 34169 35082 35720 35922 35950 35959 36104 36156 36463 36648 36860 36985 36991 36998 37049 37062 37067 37211 37591 37604 37839 38016 38023 38085 38091 38132 38367 39383 40782 41773 41869 41902 42044 42841 42982 43010 43023 43465 43578 43605 43704 43796 44080 44226 44241 44612 44688 44992 45293 45300 46811 47010 47195 47424 47632 47759 47782 47974 48196 48204 48208 48225 48501 48732 49324 50141 50143 50463

GlyTouCan:

LIPIDMAPS:

JCGGDB:

LipidBank:

GlycoEpitope:

LinkDB

KCF data

NODE        4
            1   Cer        13     0
            2   Glc         4     0
            3   Gal        -5     0
            4   Gal       -13     0
EDGE        3
            1     2:b1    1:1
            2     3:b1    2:4
            3     4:a1    3:4

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