KEGG   ORTHOLOGY: K04451
Entry
K04451                      KO                                     
Symbol
TP53, P53
Name
tumor protein p53
Pathway
map01522  Endocrine resistance
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04071  Sphingolipid signaling pathway
map04110  Cell cycle
map04115  p53 signaling pathway
map04137  Mitophagy - animal
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04211  Longevity regulating pathway
map04216  Ferroptosis
map04218  Cellular senescence
map04310  Wnt signaling pathway
map04722  Neurotrophin signaling pathway
map04919  Thyroid hormone signaling pathway
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05016  Huntington disease
map05131  Shigellosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05203  Viral carcinogenesis
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05222  Small cell lung cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00004  Chronic myeloid leukemia
H00005  Chronic lymphocytic leukemia
H00006  Hairy cell leukemia
H00008  Burkitt lymphoma
H00009  Adult T-cell leukemia
H00010  Multiple myeloma
H00013  Small cell lung cancer
H00014  Non-small cell lung cancer
H00015  Malignant pleural mesothelioma
H00016  Oral cancer
H00017  Esophageal cancer
H00018  Gastric cancer
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00022  Bladder cancer
H00025  Penile cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00029  Vulvar cancer
H00031  Breast cancer
H00032  Thyroid cancer
H00033  Adrenal carcinoma
H00036  Osteosarcoma
H00038  Melanoma
H00039  Basal cell carcinoma
H00040  Squamous cell carcinoma
H00041  Kaposi sarcoma
H00042  Glioma
H00044  Cancer of the anal canal
H00046  Cholangiocarcinoma
H00047  Gallbladder cancer
H00048  Hepatocellular carcinoma
H00055  Laryngeal cancer
H00881  Li-Fraumeni syndrome
H01007  Choroid plexus papilloma
H01463  Mycosis fungoides
H01464  Mantle cell lymphoma
H01470  Giant cell tumor of bone
H01554  Fallopian tube cancer
H01555  Merkel cell carcinoma
H01557  Hepatic angiosarcoma
H01559  Oropharyngeal cancer
H01667  Medulloblastoma
H02301  Nephroblastoma
H02411  Chronic myelomonocytic leukemia
H02434  Diffuse large B-cell lymphoma, not otherwise specified
H02529  Bone marrow failure syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04451  TP53, P53; tumor protein p53
   04310 Wnt signaling pathway
    K04451  TP53, P53; tumor protein p53
   04071 Sphingolipid signaling pathway
    K04451  TP53, P53; tumor protein p53
   04151 PI3K-Akt signaling pathway
    K04451  TP53, P53; tumor protein p53
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04451  TP53, P53; tumor protein p53
  09143 Cell growth and death
   04110 Cell cycle
    K04451  TP53, P53; tumor protein p53
   04210 Apoptosis
    K04451  TP53, P53; tumor protein p53
   04216 Ferroptosis
    K04451  TP53, P53; tumor protein p53
   04115 p53 signaling pathway
    K04451  TP53, P53; tumor protein p53
   04218 Cellular senescence
    K04451  TP53, P53; tumor protein p53
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04451  TP53, P53; tumor protein p53
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04451  TP53, P53; tumor protein p53
  09149 Aging
   04211 Longevity regulating pathway
    K04451  TP53, P53; tumor protein p53
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04451  TP53, P53; tumor protein p53
   05202 Transcriptional misregulation in cancer
    K04451  TP53, P53; tumor protein p53
   05206 MicroRNAs in cancer
    K04451  TP53, P53; tumor protein p53
   05205 Proteoglycans in cancer
    K04451  TP53, P53; tumor protein p53
   05203 Viral carcinogenesis
    K04451  TP53, P53; tumor protein p53
   05230 Central carbon metabolism in cancer
    K04451  TP53, P53; tumor protein p53
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04451  TP53, P53; tumor protein p53
   05212 Pancreatic cancer
    K04451  TP53, P53; tumor protein p53
   05225 Hepatocellular carcinoma
    K04451  TP53, P53; tumor protein p53
   05226 Gastric cancer
    K04451  TP53, P53; tumor protein p53
   05214 Glioma
    K04451  TP53, P53; tumor protein p53
   05216 Thyroid cancer
    K04451  TP53, P53; tumor protein p53
   05220 Chronic myeloid leukemia
    K04451  TP53, P53; tumor protein p53
   05217 Basal cell carcinoma
    K04451  TP53, P53; tumor protein p53
   05218 Melanoma
    K04451  TP53, P53; tumor protein p53
   05219 Bladder cancer
    K04451  TP53, P53; tumor protein p53
   05215 Prostate cancer
    K04451  TP53, P53; tumor protein p53
   05213 Endometrial cancer
    K04451  TP53, P53; tumor protein p53
   05224 Breast cancer
    K04451  TP53, P53; tumor protein p53
   05222 Small cell lung cancer
    K04451  TP53, P53; tumor protein p53
   05223 Non-small cell lung cancer
    K04451  TP53, P53; tumor protein p53
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04451  TP53, P53; tumor protein p53
   05161 Hepatitis B
    K04451  TP53, P53; tumor protein p53
   05160 Hepatitis C
    K04451  TP53, P53; tumor protein p53
   05162 Measles
    K04451  TP53, P53; tumor protein p53
   05168 Herpes simplex virus 1 infection
    K04451  TP53, P53; tumor protein p53
   05163 Human cytomegalovirus infection
    K04451  TP53, P53; tumor protein p53
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04451  TP53, P53; tumor protein p53
   05169 Epstein-Barr virus infection
    K04451  TP53, P53; tumor protein p53
   05165 Human papillomavirus infection
    K04451  TP53, P53; tumor protein p53
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K04451  TP53, P53; tumor protein p53
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04451  TP53, P53; tumor protein p53
   05014 Amyotrophic lateral sclerosis
    K04451  TP53, P53; tumor protein p53
   05016 Huntington disease
    K04451  TP53, P53; tumor protein p53
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04451  TP53, P53; tumor protein p53
   05418 Fluid shear stress and atherosclerosis
    K04451  TP53, P53; tumor protein p53
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04451  TP53, P53; tumor protein p53
   01522 Endocrine resistance
    K04451  TP53, P53; tumor protein p53
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04451  TP53, P53; tumor protein p53
   03036 Chromosome and associated proteins
    K04451  TP53, P53; tumor protein p53
   03400 DNA repair and recombination proteins
    K04451  TP53, P53; tumor protein p53
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   p53
    K04451  TP53, P53; tumor protein p53
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04451  TP53, P53; tumor protein p53
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K04451  TP53, P53; tumor protein p53
Genes
HSA: 7157(TP53)
PTR: 455214(TP53)
PPS: 100973941(TP53)
GGO: 101133524(TP53)
PON: 100435218(TP53)
PPYG: 129017148(TP53)
NLE: 100583326(TP53)
HMH: 116459052(TP53)
SSYN: 129469721(TP53)
MCC: 716170(TP53)
MCF: 102135998(TP53)
MTHB: 126939707
MNI: 105473688(TP53)
CSAB: 103242323(TP53)
CATY: 105582225(TP53)
PANU: 101006608(TP53)
TGE: 112610199(TP53)
MLEU: 105549866(TP53)
RRO: 104661662(TP53)
RBB: 108514363(TP53)
TFN: 117067758(TP53)
PTEH: 111527100(TP53)
CANG: 105523626(TP53)
CJC: 100415710(TP53)
SBQ: 101043647(TP53)
CIMI: 108306559(TP53)
ANAN: 105720742(TP53)
CSYR: 103264637(TP53)
MMUR: 105877486(TP53)
LCAT: 123650900(TP53)
PCOQ: 105819395(TP53)
OGA: 100963622(TP53)
MMU: 22059(Trp53)
MCAL: 110305297(Tp53)
MPAH: 110331731(Tp53)
RNO: 24842(Tp53)
MCOC: 116077116(Tp53)
ANU: 117710574(Tp53)
ASYL: 127694234(Tp53)
MUN: 110555127(Tp53)
CGE: 100682525(Tp53)
MAUA: 101833915(Tp53)
PROB: 127219059(Tp53) 127231704
PLEU: 114693171(Tp53)
MORG: 121456449(Tp53)
MFOT: 126513928
AAMP: 119813419(Tp53) 119818608
NGI: 103752115(Tp53)
HGL: 101701769(Tp53)
CPOC: 100379269(Tp53)
CCAN: 109674834(Tp53)
DORD: 105983546(Tp53)
DSP: 122100440(Tp53)
PLOP: 125365886(Tp53)
NCAR: 124980281
MMMA: 107158007(Tp53)
ITI: 101957738(Tp53)
OCU: 100009292(TP53)
OPI: 101528346(TP53)
TUP: 102503238(TP53)
GVR: 103591400(TP53)
CFA: 403869(TP53)
CLUD: 112647438(TP53)
VVP: 112924853(TP53)
VLG: 121499929(TP53)
NPO: 129497070(TP53)
AML: 100468516(TP53)
UMR: 103660368(TP53)
UAH: 113271152(TP53)
UAR: 123792132(TP53)
ELK: 111161133
LLV: 125087037
MPUF: 101677794(TP53)
MNP: 132003790(TP53)
MLK: 131815809(TP53)
NVS: 122906719(TP53)
ORO: 101362427(TP53)
EJU: 114225325(TP53)
ZCA: 113939587(TP53)
MLX: 118000034(TP53)
NSU: 110584444(TP53)
LWW: 102726420(TP53)
FCA: 493847(TP53)
PYU: 121015982(TP53)
PCOO: 112856999(TP53)
PBG: 122484900(TP53)
PVIV: 125151405(TP53)
LRUF: 124519563
PTG: 102962571(TP53)
PPAD: 109245932(TP53)
PUC: 125927023
AJU: 106972437
HHV: 120231386(TP53)
BTA: 281542(TP53)
BOM: 102272370(TP53)
BIU: 109574238(TP53)
BBUB: 102402069(TP53)
BBIS: 104990761(TP53)
CHX: 102169621(TP53)
OAS: 443421(TP53)
BTAX: 128049822 128064672(TP53)
CSUM: 138083162(TP53)
ODA: 120866037(TP53)
CCAD: 122445826(TP53)
MREE: 136149830(TP53)
OVR: 110121763(TP53)
MBEZ: 129543141(TP53)
SSC: 397276(TP53)
CFR: 102524476(TP53)
CBAI: 105077515(TP53)
CDK: 105103011(TP53)
VPC: 102530959(TP53)
BACU: 103003426(TP53)
BMUS: 118886638(TP53)
LVE: 103089875(TP53)
OOR: 101285670(TP53)
DLE: 111185755(TP53)
PCAD: 102985658(TP53)
PSIU: 116745739(TP53)
NASI: 112401891(TP53)
ECB: 100062044(TP53)
EPZ: 103557703(TP53)
EAI: 106844218(TP53)
MYB: 102244768(TP53)
MYD: 102759012(TP53)
MMYO: 118672084(TP53)
MLF: 102431418(TP53)
MDT: 132218058(TP53)
PKL: 118726809(TP53)
EFUS: 103296897(TP53)
MNA: 107538830 107544572(TP53)
DRO: 112308825(TP53)
SHON: 118974748(TP53)
AJM: 119053542(TP53) 119059042
PDIC: 114515376(TP53)
PHAS: 123809443(TP53)
MMF: 118634552(TP53)
PPAM: 129072290(TP53)
HAI: 109394672(TP53)
RFQ: 117013763(TP53)
PALE: 102889604(TP53)
PGIG: 120589680(TP53)
PVP: 105291226(TP53)
RAY: 107515689(TP53)
MJV: 108404266(TP53) 118974052
TOD: 119230677(TP53)
SARA: 101558045(TP53)
SFUM: 130024222(TP53)
SETR: 125998025(TP53)
LAV: 100663725(TP53)
TMU: 101351852
ETF: 101647784 101656530(TP53)
DNM: 101416069(TP53)
MDO: 497248(TP53)
GAS: 123244534(TP53)
SHR: 100922473(TP53)
AFZ: 127560870
PCW: 110194271(TP53)
TVP: 118856593(TP53)
PBRV: 138173979(TP53)
OAA: 100092821(TP53)
TACU: 119946776(TP53)
LSR: 110480316(TP53)
PMOA: 120510412
PHI: 102101491(TP53)
ACOE: 138100819(TP53)
ZLE: 135460545(TP53)
SHAB: 115602932(TP53)
ACHC: 115338264(TP53)
AGEN: 126034674
ASN: 102376594(TP53)
AMJ: 102570618(TP53)
PSS: 102448135(TP53)
CMY: 102934531(TP53)
CCAY: 125628652(TP53)
DCC: 119849273(TP53)
CPIC: 101942845(TP53)
CABI: 116833193(TP53)
MRV: 120381866(TP53)
ACS: 103282543
ASAO: 132777525 132777527 132777528
PVT: 110087754(TP53)
SUND: 121932555(TP53)
PBI: 103061365(TP53) 112542108
PMUR: 107299049
CTIG: 120305710(TP53)
TSR: 106537915
PGUT: 117657734(TP53)
APRI: 131197474(TP53)
PTEX: 113451334(TP53)
NSS: 113427879
VKO: 123016682(TP53)
PMUA: 114608083(TP53)
PRAF: 128399324(TP53)
ZVI: 118094938(TP53)
HCG: 128331404 128331417
GJA: 107121079(TP53)
EMC: 129340394(TP53)
XLA: 108703451(tp53.S) 397926(tp53.L)
XTR: 431679(tp53)
NPR: 108784730
RTEM: 120933851(TP53)
BBUF: 120986731
BGAR: 122928180(TP53)
MUO: 115457986(TP53)
GSH: 117350793(TP53)
DRE: 30590(tp53)
SRX: 107726386 107744460
SANH: 107672786 107687672
SGH: 107592291 107599945
CCAR: 109082764 109083614
CAUA: 113048774 113091288 113098897
CGIB: 127957502 127972656 128011372 128017696
PTET: 122345417(tp53) 122347860
LROH: 127160767 127165300(tp53)
OMC: 131541252(tp53) 131543330
PPRM: 120469826(tp53) 120477867
RKG: 130071217(tp53) 130076855
MAMB: 125265599 125266618(tp53)
CIDE: 127512451 127516134
CERY: 137030267 137033575(tp53)
MASI: 127412460 127423032 127439189
TROS: 130546879(tp53) 130554163
TDW: 130419306(tp53) 130424437
MANU: 129439993(tp53) 129449447
IPU: 100304476(tp53) 108267915
IFU: 128609972(tp53)
PHYP: 113540585
SMEO: 124379345(tp53) 124386843
TFD: 113657603 113663944(tp53)
TVC: 132840785(tp53) 132848547
TRN: 134303666(tp53) 134312284
AMEX: 103037427 103046742(tp53)
CMAO: 118814925(tp53) 118826251
EEE: 113570174(tp53) 113577352
CHAR: 105906573 105906613 105907172
SPIL: 134059443 134080610(tp53)
TRU: 101079595
TFS: 130522133(tp53)
TNG: GSTEN00019217G001
LCO: 104923960(tp53)
NCC: 104945430(tp53)
TBEN: 117488086(tp53)
CGOB: 115023713
PGEO: 117463689(tp53)
GACU: 117552767(tp53)
EMAC: 134875854(tp53)
ELY: 117246251(tp53)
EFO: 125883865(tp53)
PLEP: 121961825(tp53)
SLUC: 116049038(tp53)
ECRA: 117962210(tp53)
ESP: 116686339
PFLV: 114545465
GAT: 120821893(tp53)
PPUG: 119222594(tp53)
AFB: 129093061(tp53)
CLUM: 117747715(tp53)
PSWI: 130211870(tp53)
CANA: 137791954(tp53)
CVE: 137874551(tp53)
MSAM: 119911875(tp53)
SCHU: 122870059(tp53)
CUD: 121504579(tp53)
SPUL: 138600883
LMIX: 132958779(tp53)
ALAT: 119027521(tp53)
ASTR: 137590814(tp53)
MZE: 101480650 112432676
ONL: 100702587(p53)
OAU: 116310388(tp53)
OLA: 100049321(tp53)
OML: 112156259(tp53)
CSAI: 133420070(tp53)
XMA: 102219062(tp53)
XCO: 114157824(tp53)
XHE: 116722833 116732253(tp53)
PRET: 103480460(tp53)
PFOR: 103137501(tp53)
PLAI: 106945775(tp53)
PMEI: 106919132(tp53)
GAF: 122819959(tp53)
PPRL: 129354903(tp53)
CVG: 107087774(tp53)
CTUL: 119783414(tp53)
GMU: 124880555(tp53)
NFU: 107377392(tp53)
KMR: 108228351(tp53)
ALIM: 106525321(tp53)
NWH: 119416239
AOCE: 111577187
EJA: 138210562(tp53)
BFRE: 138635425(tp53)
MCEP: 125010254 125019542 125019568 125019584
CSEM: 103387239(tp53)
POV: 109634900
SSEN: 122767329(tp53)
HHIP: 117752065(tp53)
HSP: 118102319(tp53)
PPLT: 128429801(tp53)
SMAU: 118320602(tp53)
LCF: 108879980(tp53)
SDU: 111233015
SLAL: 111650698
XGL: 120797533(tp53)
HCQ: 109528457
SSCV: 125990249
SBIA: 133494790(tp53)
PEE: 133397665(tp53) 133416941
PTAO: 133468655 133472385(tp53)
BPEC: 110159471(tp53)
MALB: 109951400(tp53)
BSPL: 114846247 114850503(tp53) 114860643
SJO: 128383873(tp53)
SSCO: 134005608(tp53)
SASA: 106577554 106602901(tp53) 106608673(P53)
STRU: 115154926 115194175 115198177
OTW: 112214763 112229014(tp53) 112260048
OMY: 100136737(tp53) 110500680 110531824
OGO: 124005493(tp53) 124008155 124014289
ONE: 115133606 115135425(tp53) 115138149
OKI: 109873031(tp53) 109897084 109906265
OKE: 118368687 118390576(tp53) 118391918
OMM: 135510682 135516385 135550215(tp53)
SALP: 111950504 111954968 111960314
SNH: 120030359 120049611 120057360(tp53)
CCLU: 121554328 121571135 121579683(tp53)
ELS: 105008589 105020676
SFM: 108921730(tp53) 108923185
PKI: 111850623(tp53) 111854492
AANG: 118223000 118235846(tp53)
AROT: 135251404 135263502(tp53)
CCOG: 133124472 133132365(tp53)
LOC: 102690789(tp53)
PSPA: 121305685 121306517
ARUT: 117404615 117970978
PSEX: 120525038(tp53)
LCM: 102366539(TP53)
CPLA: 122543388(tp53)
HOC: 132835339
AMOU: 128297781
AGB: 108914996
OTU: 111428129
BMOR: 100384887(p53)
BMAN: 114240525
BANY: 112042832
VCD: 124533027
MCIX: 123663701
PPOT: 106109054
PXU: 106117969
BPHI: 137923949(p53)
ZCE: 119836279
AAGE: 121733245
HAW: 110371726
TNL: 113502856
ATRA: 106133260
GMW: 113515233
PGW: 126375901
LGLY: 125236351
CSTB: 134750040
API: 100575088
DNX: 107172567
AGS: 114120933
RMD: 113548792
MQU: 128985371
FOC: 113211063
TPAL: 117644168
IEL: 124156387
TCF: 131884647 131885789
DSV: 119435540 119446786
RSAN: 119406532
RMP: 119177246 119182654
VDE: 111251447
VJA: 111269297
ABRU: 129968735
UDV: 129229375 129230379
SDM: 118184104
LPOL: 106457540
NAI: NECAME_18530
LOA: LOAG_07717
TSP: Tsp_05266
HRO: HELRODRAFT_107137
EPA: 110233133 110241777
XEN: 124441058 124444930 124453897 124459174
HMG: 100207213
SRE: PTSG_07599
 » show all
Reference
PMID:16131611
  Authors
Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP, Saville MK, Lane DP
  Title
p53 isoforms can regulate p53 transcriptional activity.
  Journal
Genes Dev 19:2122-37 (2005)
DOI:10.1101/gad.1339905
  Sequence
[hsa:7157]
Reference
PMID:9840937
  Authors
Schneider E, Montenarh M, Wagner P
  Title
Regulation of CAK kinase activity by p53.
  Journal
Oncogene 17:2733-41 (1998)
DOI:10.1038/sj.onc.1202504
  Sequence
[hsa:7157]
Reference
PMID:4006916
  Authors
Zakut-Houri R, Bienz-Tadmor B, Givol D, Oren M
  Title
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.
  Journal
EMBO J 4:1251-5 (1985)
DOI:10.1002/j.1460-2075.1985.tb03768.x
  Sequence
[hsa:7157]
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