KEGG   DRUG: Pemigatinib
Entry
D11417                      Drug                                   
Name
Pemigatinib (JAN/USAN/INN);
Pemazyre (TN)
Product
Formula
C24H27F2N5O4
Exact mass
487.2031
Mol weight
487.4991
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03208  FGFR inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 4291
ATC code: L01EN02
Product: D11417<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Cholangiocarcinoma (FGFR2 fusion positive) [DS:H00046]
Target
FGFR2* (CD332) [HSA_VAR:2263v2] [HSA:2263] [KO:K05093]
FGFR1 (CD331) [HSA:2260] [KO:K04362]
FGFR3 (CD333) [HSA:2261] [KO:K05094]
  Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EN Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors
     L01EN02 Pemigatinib
      D11417  Pemigatinib (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Pemigatinib
    D11417  Pemigatinib (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D11417  Pemigatinib (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     D11417  Pemigatinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11417  Pemigatinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR1 (CD331)
     D11417  Pemigatinib (JAN/USAN/INN) <JP/US>
    FGFR2* (CD332) [HSA_VAR:2263v2]
     D11417  Pemigatinib (JAN/USAN/INN) <JP/US>
    FGFR3 (CD333)
     D11417  Pemigatinib (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11417
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11417
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11417
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11417
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11417
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D11417
Other DBs
CAS: 1513857-77-6
PubChem: 384585394
PDB-CCD: 8ZF[PDBj]
LinkDB
KCF data

ATOM        35
            1   C8y C    18.2000  -16.5900
            2   C8x C    18.2000  -17.9900
            3   N5x N    17.0100  -18.6900
            4   C8y C    15.7500  -17.9900
            5   C8y C    15.7500  -16.5900
            6   C8y C    17.0100  -15.8900
            7   C8x C    14.4200  -16.1700
            8   C8y C    13.5800  -17.2900
            9   N4x N    14.4200  -18.4100
            10  C1b C    12.1800  -17.2900
            11  N1y N    11.4800  -16.1000
            12  C1x C    12.1800  -14.9100
            13  C1x C    11.4800  -13.6500
            14  O2x O    10.0800  -13.6500
            15  C1x C     9.3800  -14.8400
            16  C1x C    10.0800  -16.1000
            17  C1x C    19.4600  -15.8900
            18  N1y N    19.4600  -14.4900
            19  C5x C    18.2700  -13.7900
            20  N1y N    17.0100  -14.4900
            21  C1b C    15.8200  -13.7900
            22  C1a C    14.5600  -14.4900
            23  O5x O    18.2700  -12.3900
            24  C8y C    20.6500  -13.7900
            25  C8y C    21.9100  -14.4200
            26  C8y C    23.0300  -13.7200
            27  C8x C    23.0300  -12.3200
            28  C8y C    21.8400  -11.6200
            29  C8y C    20.6500  -12.3900
            30  O2a O    24.2200  -14.4200
            31  C1a C    25.4100  -13.7200
            32  O2a O    21.8400  -10.2200
            33  C1a C    20.5800   -9.5200
            34  X   F    21.9100  -15.8200
            35  X   F    19.4600  -11.6900
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    4   9 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   11  16 1
            19    1  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23    6  20 1
            24   20  21 1
            25   21  22 1
            26   19  23 2
            27   18  24 1
            28   24  25 2
            29   25  26 1
            30   26  27 2
            31   27  28 1
            32   28  29 2
            33   24  29 1
            34   26  30 1
            35   30  31 1
            36   28  32 1
            37   32  33 1
            38   25  34 1
            39   29  35 1

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