Nasopharyngeal carcinoma (NPC) is a rare disease in most parts of the world, with an age-standardised annual incidence of less than 1 per 100000. However, in Southern China, parts of Southeast Asia and the Mediterranean basin, NPC is an endemic disease with an incidence of 10-30 per 100000. Genome-wide studies have unravelled multiple chromosomal abnormalities with involvement of specific oncogenes and tumor suppressor genes. Alterations of genes such as Ras association domain family 1A (RASSF1A), p16/INK4A, p14/ARF suggest that multiple cellular pathways were dysregulated in the NPC cells. Studies on the precancerous lesions revealed early genetic changes and a critical role of Epstein- Barr virus (EBV) latent infection in the development of this cancer.
Category
Cancer
Brite
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms of lip, oral cavity or pharynx
2B6B Malignant neoplasms of nasopharynx
H00054 Nasopharyngeal cancer
Pathway-based classification of diseases [BR:br08402]
Signal transduction
nt06530 PI3K signaling
H00054 Nasopharyngeal cancer
nt06518 JAK-STAT signaling
H00054 Nasopharyngeal cancer
nt06516 TNF signaling
H00054 Nasopharyngeal cancer
nt06528 Calcium signaling
H00054 Nasopharyngeal cancer
Cellular process
nt06524 Apoptosis
H00054 Nasopharyngeal cancer
Innate immunity
nt06517 TLR signaling
H00054 Nasopharyngeal cancer
nt06519 RLR signaling
H00054 Nasopharyngeal cancer
Dai W, Zheng H, Cheung AK, Tang CS, Ko JM, Wong BW, Leong MM, Sham PC, Cheung F, Kwong DL, Ngan RK, Ng WT, Yau CC, Pan J, Peng X, Tung S, Zhang Z, Ji M, Chiang AK, Lee AW, Lee VH, Lam KO, Au KH, Cheng HC, Yiu HH, Lung ML
Title
Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.
