KEGG   DISEASE: 鼻咽頭癌
エントリ  
H00054                                                             
名称    
鼻咽頭癌
概要    
Nasopharyngeal carcinoma (NPC) is a rare disease in most parts of the world, with an age-standardised annual incidence of less than 1 per 100000. However, in Southern China, parts of Southeast Asia and the Mediterranean basin, NPC is an endemic disease with an incidence of 10-30 per 100000. Genome-wide studies have unravelled multiple chromosomal abnormalities with involvement of specific oncogenes and tumor suppressor genes. Alterations of genes such as Ras association domain family 1A (RASSF1A), p16/INK4A, p14/ARF suggest that multiple cellular pathways were dysregulated in the NPC cells. Studies on the precancerous lesions revealed early genetic changes and a critical role of Epstein- Barr virus (EBV) latent infection in the development of this cancer.
カテゴリ  
がん
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍, 原発性と確定または推定されるもの, 明示された部位のもの, ただしリンパ, 造血, 中枢神経系, 関連組織を除く
    口唇, 口腔, 咽頭の悪性腫瘍
     2B6B  上咽頭の悪性腫瘍
      H00054  鼻咽頭癌
パスウェイに基づく疾患分類 [BR:jp08402]
 シグナル伝達
  nt06518  JAK-STAT シグナリング
   H00054  鼻咽頭癌
  nt06516  TNF シグナリング
   H00054  鼻咽頭癌
 細胞プロセス
  nt06524  アポトーシス
   H00054  鼻咽頭癌
 免疫系
  nt06517  TLR シグナリング
   H00054  鼻咽頭癌
  nt06519  RLR シグナリング
   H00054  鼻咽頭癌
  nt06537  TCR/BCR シグナリング
   H00054  鼻咽頭癌
パスウェイ 
hsa05169  Epstein-Barr virus infection
ネットワーク
nt06516 TNF signaling
nt06517 TLR signaling
nt06518 JAK-STAT signaling
nt06519 RLR signaling
nt06524 Apoptosis
nt06537 TCR/BCR signaling
病因遺伝子 
(NPCA3) MST1R [HSA:4486] [KO:K05100]
RASSF1 (promoter hypermethylation) [HSA:11186] [KO:K09850]
CDKN2A (promoter hypermethylation) [HSA:1029] [KO:K06621]
BCL2 (overexpression) [HSA:596] [KO:K02161]
EDNRB (promoter hypermethylation) [HSA:1910] [KO:K04198]
CADM1 (promoter hypermethylation) [HSA:23705] [KO:K06781]
CDH1 (decreased expression) [HSA:999] [KO:K05689]
病原体   
Human herpesvirus 4 (Epstein-Barr virus) [GN:T40079]
リンク   
ICD-11: 2B6B
ICD-10: C11
MeSH: D009303
OMIM: 617075
文献    
PMID:26951679 (NPCA3)
  著者
Dai W, Zheng H, Cheung AK, Tang CS, Ko JM, Wong BW, Leong MM, Sham PC, Cheung F, Kwong DL, Ngan RK, Ng WT, Yau CC, Pan J, Peng X, Tung S, Zhang Z, Ji M, Chiang AK, Lee AW, Lee VH, Lam KO, Au KH, Cheng HC, Yiu HH, Lung ML
  タイトル
Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.
  雑誌
Proc Natl Acad Sci U S A 113:3317-22 (2016)
DOI:10.1073/pnas.1523436113
文献    
PMID:12450731 (GENE)
  著者
Lo KW, Huang DP.
  タイトル
Genetic and epigenetic changes in nasopharyngeal carcinoma.
  雑誌
Semin Cancer Biol 12:451-62 (2002)
DOI:10.1016/S1044579X02000883
文献    
  著者
Chan AT
  タイトル
Head and neck cancer: treatment of nasopharyngeal cancer.
  雑誌
Ann Oncol 16 Suppl 2:ii265-8 (2005)
DOI:10.1093/annonc/mdi732
文献    
  著者
Young LS, Rickinson AB.
  タイトル
Epstein-Barr virus: 40 years on.
  雑誌
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
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