KEGG   ORTHOLOGY: K02161
Entry
K02161                      KO                                     

Symbol
BCL2
Name
apoptosis regulator Bcl-2
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map01524  Platinum drug resistance
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04071  Sphingolipid signaling pathway
map04115  p53 signaling pathway
map04140  Autophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04215  Apoptosis - multiple species
map04217  Necroptosis
map04261  Adrenergic signaling in cardiomyocytes
map04340  Hedgehog signaling pathway
map04510  Focal adhesion
map04621  NOD-like receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04722  Neurotrophin signaling pathway
map04725  Cholinergic synapse
map04915  Estrogen signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04933  AGE-RAGE signaling pathway in diabetic complications
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05131  Shigellosis
map05132  Salmonella infection
map05145  Toxoplasmosis
map05152  Tuberculosis
map05161  Hepatitis B
map05162  Measles
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05210  Colorectal cancer
map05215  Prostate cancer
map05222  Small cell lung cancer
map05226  Gastric cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00005  Chronic lymphocytic leukemia
H00013  Small cell lung cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00041  Kaposi sarcoma
H00054  Nasopharyngeal cancer
H01613  Follicular lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02161  BCL2; apoptosis regulator Bcl-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04630 JAK-STAT signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04064 NF-kappa B signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04066 HIF-1 signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04071 Sphingolipid signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04151 PI3K-Akt signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02161  BCL2; apoptosis regulator Bcl-2
  09143 Cell growth and death
   04210 Apoptosis
    K02161  BCL2; apoptosis regulator Bcl-2
   04215 Apoptosis - multiple species
    K02161  BCL2; apoptosis regulator Bcl-2
   04217 Necroptosis
    K02161  BCL2; apoptosis regulator Bcl-2
   04115 p53 signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02161  BCL2; apoptosis regulator Bcl-2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04928 Parathyroid hormone synthesis, secretion and action
    K02161  BCL2; apoptosis regulator Bcl-2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K02161  BCL2; apoptosis regulator Bcl-2
  09156 Nervous system
   04725 Cholinergic synapse
    K02161  BCL2; apoptosis regulator Bcl-2
   04722 Neurotrophin signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05206 MicroRNAs in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05207 Chemical carcinogenesis - receptor activation
    K02161  BCL2; apoptosis regulator Bcl-2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05226 Gastric cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05215 Prostate cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05222 Small cell lung cancer
    K02161  BCL2; apoptosis regulator Bcl-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05161 Hepatitis B
    K02161  BCL2; apoptosis regulator Bcl-2
   05162 Measles
    K02161  BCL2; apoptosis regulator Bcl-2
   05168 Herpes simplex virus 1 infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05169 Epstein-Barr virus infection
    K02161  BCL2; apoptosis regulator Bcl-2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05131 Shigellosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05152 Tuberculosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05022 Pathways of neurodegeneration - multiple diseases
    K02161  BCL2; apoptosis regulator Bcl-2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05418 Fluid shear stress and atherosclerosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02161  BCL2; apoptosis regulator Bcl-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02161  BCL2; apoptosis regulator Bcl-2
   01524 Platinum drug resistance
    K02161  BCL2; apoptosis regulator Bcl-2
   01522 Endocrine resistance
    K02161  BCL2; apoptosis regulator Bcl-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K02161  BCL2; apoptosis regulator Bcl-2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02161  BCL2; apoptosis regulator Bcl-2
Genes
HSA: 596(BCL2)
PTR: 738409(BCL2)
PPS: 100992951(BCL2)
GGO: 101136123(BCL2)
PON: 100938429(BCL2)
NLE: 100599011(BCL2)
MCC: 707407(BCL2)
MCF: 102138212(BCL2)
CSAB: 103244166(BCL2)
CATY: 105590006(BCL2)
PANU: 101026183(BCL2)
RRO: 104682248(BCL2)
RBB: 108526412(BCL2)
TFN: 117099723(BCL2)
PTEH: 111528437(BCL2)
CJC: 100408947(BCL2)
SBQ: 101051366(BCL2)
MMUR: 105876728(BCL2)
MMU: 12043(Bcl2)
MCAL: 110302433(Bcl2)
MPAH: 110321591(Bcl2)
RNO: 24224(Bcl2)
MCOC: 116097315(Bcl2)
MUN: 110557800(Bcl2)
CGE: 100774873(Bcl2)
PLEU: 114702810(Bcl2)
NGI: 103740099(Bcl2)
HGL: 101701667(Bcl2)
CCAN: 109693757(Bcl2)
OCU: 103349397(BCL2)
OPI: 101517543(BCL2)
TUP: 102474592(BCL2)
CFA: 403416(BCL2)
VVP: 112919203(BCL2)
VLG: 121481811(BCL2)
AML: 100484344(BCL2)
UMR: 103676164(BCL2)
UAH: 113253490(BCL2)
ORO: 101372267(BCL2)
ELK: 111154217
MPUF: 101681308(BCL2)
EJU: 114208840(BCL2)
MLX: 118004389(BCL2)
FCA: 493934(BCL2)
PYU: 121032687(BCL2)
PBG: 122470833(BCL2)
PTG: 102953487(BCL2)
PPAD: 109275625(BCL2)
AJU: 106985187(BCL2)
HHV: 120245032(BCL2)
BTA: 281020(BCL2)
BOM: 102268592(BCL2)
BIU: 109577782(BCL2)
BBUB: 102402077(BCL2)
CHX: 100861254(BCL2)
OAS: 101119602(BCL2)
ODA: 120880862(BCL2)
CCAD: 122425862(BCL2)
SSC: 100049703(BCL2)
CFR: 102518434(BCL2)
CBAI: 105073903(BCL2)
CDK: 105088999(BCL2)
BACU: 103015542(BCL2)
LVE: 103077294(BCL2)
OOR: 101276750(BCL2)
DLE: 111180199(BCL2)
PCAD: 102987942(BCL2)
ECB: 100050934(BCL2)
EPZ: 103550767(BCL2)
EAI: 106832883(BCL2)
MYB: 102248597(BCL2)
MYD: 102769473(BCL2)
MMYO: 118663765(BCL2)
MNA: 107545431(BCL2)
HAI: 109390784(BCL2)
DRO: 112322759(BCL2)
SHON: 118979386(BCL2)
AJM: 119057575(BCL2)
MMF: 118619009(BCL2)
PALE: 102896443(BCL2)
PGIG: 120584396(BCL2)
RAY: 107503915(BCL2)
MJV: 108385222(BCL2)
TOD: 119243742(BCL2)
LAV: 100675268(BCL2)
TMU: 101347007
MDO: 100016570(BCL2)
SHR: 100934666(BCL2)
PCW: 110214751(BCL2)
OAA: 114807635(BCL2)
GGA: 396282(BCL2)
PCOC: 116226390(BCL2)
MGP: 100545008(BCL2)
CJO: 107309650(BCL2)
NMEL: 110395041(BCL2)
APLA: 110352991(BCL2)
ACYG: 106039908(BCL2)
TGU: 100224888(BCL2)
LSR: 110470703(BCL2)
SCAN: 108964924(BCL2)
PMOA: 120508336(BCL2)
OTC: 121348363(BCL2)
PRUF: 121358052(BCL2)
GFR: 102032008(BCL2)
FAB: 101818228(BCL2)
PHI: 102113262(BCL2)
PMAJ: 107200701(BCL2)
CCAE: 111923860(BCL2)
CCW: 104698161(BCL2)
ETL: 114065315(BCL2)
FPG: 101921728(BCL2)
FCH: 102056589(BCL2)
CLV: 102092853(BCL2)
NNI: 104021857(BCL2)
ACUN: 113476058(BCL2)
PADL: 103919231(BCL2)
AAM: 106482986(BCL2)
AROW: 112972797(BCL2)
NPD: 112943408(BCL2)
DNE: 112992509(BCL2)
ASN: 102370035(BCL2)
AMJ: 102564752(BCL2)
CPOO: 109314888(BCL2)
GGN: 109300860(BCL2)
PSS: 102444136(BCL2)
CMY: 102941395(BCL2)
CPIC: 101937209(BCL2)
TST: 117873081(BCL2)
CABI: 116832013(BCL2)
ACS: 100564886(bcl2)
PVT: 110075422(BCL2)
PBI: 103059077(BCL2)
PMUR: 107283580(BCL2)
TSR: 106551867(BCL2)
PGUT: 117674759(BCL2)
PMUA: 114600980(BCL2)
ZVI: 118090513(BCL2)
GJA: 107108130
XLA: 100271914(bcl2.S) 108719105(bcl2.L)
XTR: 100485267(bcl2)
NPR: 108793666(BCL2)
DRE: 100007048(bcl2b) 570772(bcl2a)
CCAR: 109049771 109050096(bcl2)
IPU: 108256596(bcl2) 108267470(BCL2)
EEE: 113570065(bcl2) 113573821
TRU: 101071405(bcl2)
LCO: 104918293(bcl2) 104939569
NCC: 104957668
CGOB: 115021999(bcl2)
ELY: 117262998(bcl2b) 117264318
PLEP: 121951449(bcl2b)
SLUC: 116046065(bcl2b) 116057842
ECRA: 117953749(bcl2b)
GAT: 120815681(bcl2b)
PPUG: 119209072(bcl2b)
CUD: 121519978(bcl2b)
MZE: 101466853(bcl2) 101477921
ONL: 100710191(bcl2) 102079353
OAU: 116316987(bcl2b) 116336531
OLA: 101163032(bcl2)
OML: 112147591(bcl2b)
XMA: 102223266(bcl2)
XCO: 114146495(bcl2)
XHE: 116721302(bcl2)
PRET: 103479578(bcl2)
CTUL: 119782733 119795680(bcl2b)
NFU: 107383942(bcl2)
KMR: 108229311 108239676(bcl2b)
ALIM: 106534253(bcl2)
CSEM: 103396176(bcl2)
POV: 109640281
LCF: 108883441(bcl2) 108890128
SDU: 111236887 111239004(bcl2)
XGL: 120789915 120799277(bcl2b)
HCQ: 109521170
BPEC: 110157967(bcl2)
MALB: 109957760
LOC: 102684940(bcl2)
CMK: 103183201(bcl2a)
RTP: 109930204
CIN: 100183575
SKO: 100374347
ZNE: 110829820
DSV: 119442335
PTEP: 107438756
MYI: 110449714
EPA: 110231689
ADF: 107334727
AMIL: 114959371
SPIS: 111341929
DGT: 114531784
AQU: 100635395
VG: 26836919(vBcl-2)
 » show all
Reference
PMID:3523487
  Authors
Tsujimoto Y, Croce CM
  Title
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
  Journal
Proc Natl Acad Sci U S A 83:5214-8 (1986)
DOI:10.1073/pnas.83.14.5214
  Sequence
[hsa:596]
Reference
  Authors
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B
  Title
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.
  Journal
Mol Cell 30:678-88 (2008)
DOI:10.1016/j.molcel.2008.06.001
  Sequence
[hsa:596]
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