KEGG   DISEASE: Legionellosis
Entry
H00311                      Disease                                
Name
Legionellosis;
Legionnaires disease
Description
Legionnaires disease (LD), caused by Gram-negative Legionella spp., can be nosocomial, community acquired or travel related. L. pneumophila is the most common cause of LD. The source of LD is potable water systems that become colonized by the microorganism, transmitted by inhalation of contaminated aerosols and aspiration. Classically, it can cause two different forms of disease in humans: LD, with an incubation period of 2-10 days, which is a multisystem illness that involves the lungs, causing pneumonia, and can cause neurological symptoms, diarrhea and high mortality (up to 50%), and Pontiac fever, with a shorter incubation period of 1-2 days, which is an acute, self-limited, influenza-like disease that does not cause pneumonia. Patients who are at risk for infection include the immunosuppressed, especially those submitted to transplantation (mainly of solid organs), those with chronic lung disease, smokers, and the elderly.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   1C19  Legionellosis
    H00311  Legionellosis
Pathway-based classification of diseases [BR:br08402]
 Immune system
  nt06517  TLR signaling
   H00311  Legionellosis
Genome-based classification of infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by other gamma proteobacteria
   H00311  Legionellosis
Disease
pathway
hsa05134  Legionellosis
Pathway
hsa04620  Toll-like receptor signaling pathway
Network
nt06517 TLR signaling
Gene
TLR5 [HSA:7100] [KO:K10168]
Pathogen
Legionella pneumophila [GN:lpn lpf lpp lpc lpa lpe]
Legionella longbeachae [GN:llo]
Legionella sainthelensi [GN:lsh]
pore-forming toxin [KO:K11022]
Drug
Erythromycin [DR:D00140]
Erythromycin ethylsuccinate [DR:D01361]
Erythromycin lactobionate [DR:D02009]
Erythromycin stearate [DR:D02184]
Other DBs
ICD-11: 1C19
ICD-10: A48.1 A48.2
MeSH: D007876 D007877
MedlinePlus: 000616
OMIM: 608556
Reference
  Authors
Carratala J, Garcia-Vidal C
  Title
An update on Legionella.
  Journal
Curr Opin Infect Dis 23:152-7 (2010)
DOI:10.1097/QCO.0b013e328336835b
Reference
  Authors
Levin AS
  Title
Nosocomial legionellosis: prevention and management.
  Journal
Expert Rev Anti Infect Ther 7:57-68 (2009)
DOI:10.1586/14787210.7.1.57
Reference
PMID:14623910 (TLR5)
  Authors
Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A
  Title
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.
  Journal
J Exp Med 198:1563-72 (2003)
DOI:10.1084/jem.20031220
LinkDB

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KEGG   DISEASE: Melioidosis
Entry
H00317                      Disease                                
Name
Melioidosis
Description
Melioidosis (MD) is an infection caused by the gram-negative soil-dwelling bacillus Burkholderia pseudomallei. It predominantly affects people in regular contact with soil and water and is endemic in areas of Southeast Asia and Northern Australia. There are many possible disease manifestations including melioidosis septic shock, pneumonia, and hepatic and splenic abscesses.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   1C42  Melioidosis
    H00317  Melioidosis
Pathway-based classification of diseases [BR:br08402]
 Immune system
  nt06517  TLR signaling
   H00317  Melioidosis
Genome-based classification of infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by beta proteobacteria
   H00317  Melioidosis
Pathway
hsa04620  Toll-like receptor signaling pathway
Network
nt06517 TLR signaling
Gene
TLR5 (resistance) [HSA:7100] [KO:K10168]
Pathogen
Burkholderia pseudomallei [GN:bps bpm bpl bpd bpr bpse bpz bpq]
Other DBs
ICD-11: 1C42
ICD-10: A24.1 A24.2 A24.3 A24.4
MeSH: D008554
OMIM: 615557
Reference
  Authors
Limmathurotsakul D, Peacock SJ
  Title
Melioidosis: a clinical overview.
  Journal
Br Med Bull 99:125-39 (2011)
DOI:10.1093/bmb/ldr007
Reference
  Authors
Wiersinga WJ, van der Poll T, White NJ, Day NP, Peacock SJ
  Title
Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei.
  Journal
Nat Rev Microbiol 4:272-82 (2006)
DOI:10.1038/nrmicro1385
Reference
PMID:23447684 (TLR5)
  Authors
West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ
  Title
Impaired TLR5 functionality is associated with survival in melioidosis.
  Journal
J Immunol 190:3373-9 (2013)
DOI:10.4049/jimmunol.1202974
LinkDB

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