KEGG   DISEASE: Syphilis
Entry
H00354                      Disease                                
Name
Syphilis
Description
Syphilis is one of the oldest recognized venereal infections caused by the spirochete Treponema pallidum subsp. pallidum. It is characterized by genital ulceration, skin rash, and development of serious systemic disease. Syphilis may also alter the course of HIV disease. Effective therapy is available but the incidence is increasing in many parts of the world.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by spirochaetes
   H00354  Syphilis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Predominantly sexually transmitted infections
   Syphilis
    1A60  Congenital syphilis
     H00354  Syphilis
    1A61  Early syphilis
     H00354  Syphilis
    1A62  Late syphilis
     H00354  Syphilis
Pathogen
Treponema pallidum [GN:tpa tpw tpp tpu tph tpo tpas]
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Demeclocycline hydrochloride [DR:D00290]
Erythromycin [DR:D00140]
Erythromycin ethylsuccinate [DR:D01361]
Erythromycin stearate [DR:D02184]
Penicillin G potassium [DR:D01053]
Penicillin G benzathine [DR:D02157]
Penicillin G procaine [DR:D02461]
Penicillin G sodium [DR:D05408]
Other DBs
ICD-11: 1A60 1A61 1A62
ICD-10: A50 A51 A52 A53
MeSH: D013587
MedlinePlus: 001327
Reference
PMID:11825779
  Authors
Antal GM, Lukehart SA, Meheus AZ
  Title
The endemic treponematoses.
  Journal
Microbes Infect 4:83-94 (2002)
DOI:10.1016/S1286-4579(01)01513-1
Reference
PMID:22133883
  Authors
Ho EL, Lukehart SA
  Title
Syphilis: using modern approaches to understand an old disease.
  Journal
J Clin Invest 121:4584-92 (2011)
DOI:10.1172/JCI57173
Reference
PMID:18510892
  Authors
Daskalakis D
  Title
Syphilis: continuing public health and diagnostic challenges.
  Journal
Curr HIV/AIDS Rep 5:72-7 (2008)
DOI:10.1007/s11904-008-0012-6
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