Syphilis

Syphilis is one of the oldest recognized venereal infections caused by the spirochete Treponema pallidum subsp. pallidum. It is characterized by genital ulceration, skin rash, and development of serious systemic disease. Syphilis may also alter the course of HIV disease. Effective therapy is available but the incidence is increasing in many parts of the world.

Infectious disease

Treponema pallidum [GN:tpa tpw tpp tpu tph tpo tpas]

Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Demeclocycline hydrochloride [DR:D00290]
Erythromycin [DR:D00140]
Erythromycin ethylsuccinate [DR:D01361]
Erythromycin stearate [DR:D02184]
Penicillin G potassium [DR:D01053]
Penicillin G benzathine [DR:D02157]
Penicillin G procaine [DR:D02461]
Penicillin G sodium [DR:D05408]

PMID:11825779

Antal GM, Lukehart SA, Meheus AZ

The endemic treponematoses.

Microbes Infect 4:83-94 (2002)
DOI:10.1016/S1286-4579(01)01513-1

PMID:22133883

Ho EL, Lukehart SA

Syphilis: using modern approaches to understand an old disease.

J Clin Invest 121:4584-92 (2011)
DOI:10.1172/JCI57173

PMID:18510892

Daskalakis D

Syphilis: continuing public health and diagnostic challenges.

Curr HIV/AIDS Rep 5:72-7 (2008)
DOI:10.1007/s11904-008-0012-6