KEGG   DISEASE: Lichen planus
Entry
H01654                      Disease                                
Name
Lichen planus
Description
Lichen planus (LP) is a chronic inflammatory and immune mediated skin disease with characteristic clinical and histopathologic features. The skin and oral mucosa are the most frequently involved areas. Other mucous membranes (including the genitalia, esophagus, and conjunctiva) and skin appendages (e.g., scalp hair and nails) can also be affected. The etiology and pathogenesis of LP remain unclear. An autoimmune reaction in which CD8+-T lymphocytes attack basal keratinocytes leading to apoptosis of the cells has been favored. Various potential triggers, e.g. viral or bacterial antigens, metal ions, drugs or physical factors, could initiate the autoimmune process. Nonetheless, the role of the individual trigger factors is controversial. There is a significant association between lichen planus and infection with hepatitis C virus (HCV). The diagnosis of LP is based on the clinical presentation and should be confirmed by biopsy, if suspected. Histopathology is often conclusive, but in vesiculobullous cutaneous LP or erosive oral LP, direct immunofluorescence (DIF) studies can be an integral step in differentiating between LP and other diseases. With few exceptions, all forms of LP are treated with the same measures. Depending on the severity of the findings, topical and systemic treatment options are available.
Category
Skin and connective tissue disease; Immune system disease
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H01654  Lichen planus
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Inflammatory dermatoses
   Papulosquamous dermatoses
    EA91  Lichen planus
     H01654  Lichen planus
Drug
Triamcinolone hexacetonide [DR:D00985]
Methylprednisolone acetate [DR:D00979]
Other DBs
ICD-11: EA91
ICD-10: L43
MeSH: D008010
Reference
  Authors
Le Cleach L, Chosidow O
  Title
Clinical practice. Lichen planus.
  Journal
N Engl J Med 366:723-32 (2012)
DOI:10.1056/NEJMcp1103641
Reference
  Authors
Gorouhi F, Davari P, Fazel N
  Title
Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis.
  Journal
ScientificWorldJournal 2014:742826 (2014)
DOI:10.1155/2014/742826
Reference
  Authors
Wagner G, Rose C, Sachse MM
  Title
Clinical variants of lichen planus.
  Journal
J Dtsch Dermatol Ges 11:309-19 (2013)
DOI:10.1111/ddg.12031
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