| Entry |
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| Name |
Methylprednisolone acetate (JAN/USP);
Depo-medrol (TN) |
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| Product |
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| Generic |
METHYLPREDNISOLONE ACETATE (A-S Medication Solutions), METHYLPREDNISOLONE ACETATE (A-S Medication Solutions), METHYLPREDNISOLONE ACETATE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE ACETATE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE ACETATE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE ACETATE (Amneal Pharmaceuticals NY LLC), METHYLPREDNISOLONE ACETATE (Endo USA), METHYLPREDNISOLONE ACETATE (Eugia US LLC), METHYLPREDNISOLONE ACETATE (Proficient Rx LP), METHYLPREDNISOLONE ACETATE (REMEDYREPACK), METHYLPREDNISOLONE ACETATE (Sagent Pharmaceuticals), METHYLPREDNISOLONE ACETATE (Sandoz) |
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| Formula |
C24H32O6
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| Exact mass |
416.2199
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| Mol weight |
416.51
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2456 |
| Product (DG00410): | D00407<JP/US> D00751<JP/US> D00979<JP/US> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
Asthma [DS: H00079] Atopic dermatitis [DS: H01358] Contact dermatitis [DS: H01357] Seasonal or perennial allergic rhinitis [DS: H01360] Bullous dermatitis herpetiformis [DS: H01362] Mcosis fungoides [DS: H01463] Pemphigus [DS: H01648] Stevens-Johnson syndrome [DS: H01694] Congenital adrenal hyperplasia [DS: H00216] Ulcerative colitis [DS: H01466] Acquired (autoimmune) hemolytic anemia [DS: H01585] Diamond blackfan anemia [DS: H00237] Multiple sclerosis [DS: H01490] Temporal arteritis [DS: H01698] Pulmonary tuberculosis [DS: H00342] Ankylosing spondylitis [DS: H01674] Psoriatic arthritis [DS: H01507] Rheumatoid arthritis [DS: H00630] Juvenile rheumatoid arthritis [DS: H01672] Dermatomyositis and polymyositis [DS: H01604] Systemic lupus erythematosus [DS: H00080] Discoid lupus erythematosus [DS: H01595] Lichen planus [DS: H01654] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA01 Methylprednisolone
D00979 Methylprednisolone acetate (JAN/USP) <JP/US>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA02 Methylprednisolone
D00979 Methylprednisolone acetate (JAN/USP) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB04 Methylprednisolone
D00979 Methylprednisolone acetate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, High Potency
Methylprednisolone
D00979 Methylprednisolone acetate (JAN/USP)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Methylprednisolone
D00979 Methylprednisolone acetate (JAN/USP)
Inflammatory Bowel Disease Agents
Glucocorticoids
Methylprednisolone
D00979 Methylprednisolone acetate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2456 Prednisolones
D00979 Methylprednisolone acetate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
D00979 Methylprednisolone acetate
Dermatological agent
DG03243 Atopic dermatitis agent
D00979 Methylprednisolone acetate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
D00979 Methylprednisolone acetate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00979 Methylprednisolone acetate
Dermatological agent
DG03243 Atopic dermatitis agent
D00979 Methylprednisolone acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00979 Methylprednisolone acetate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00979
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00410 Methylprednisolone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00410 Methylprednisolone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 C2x C 6.3700 -24.5700
2 C5x C 6.3700 -25.9700
3 C2x C 7.5824 -26.6700
4 C2y C 8.7949 -25.9700
5 C1z C 8.7949 -24.5700
6 C2x C 7.5824 -23.8700
7 C1y C 10.0073 -26.6700
8 C1x C 11.2197 -25.9700
9 C1y C 11.2197 -24.5700
10 C1y C 10.0073 -23.8700
11 C1y C 12.4322 -23.8700
12 C1z C 12.4322 -22.4700
13 C1x C 11.2197 -21.7700
14 C1y C 10.0073 -22.4700
15 C1x C 14.8570 -23.8700
16 C1x C 14.8570 -22.4700
17 C1z C 13.6446 -21.7700
18 O5x O 5.1576 -26.6700
19 C1a C 8.7949 -23.1700
20 O1a O 8.7969 -21.7712
21 C1a C 12.4322 -21.0700
22 C5a C 13.6446 -20.0900
23 C1a C 10.0073 -28.0700
24 O1a O 14.8570 -21.0700
25 C1b C 14.8611 -19.3877
26 O5a O 12.4362 -19.3923
27 O7a O 16.0586 -20.0792
28 C7a C 17.2449 -19.3943
29 C1a C 18.4367 -20.0826
30 O6a O 17.2451 -17.9902
BOND 33
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 14 20 1 #Up
24 12 21 1 #Up
25 17 22 1 #Up
26 7 23 1 #Down
27 17 24 1 #Down
28 22 25 1
29 22 26 2
30 25 27 1
31 27 28 1
32 28 29 1
33 28 30 2
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