KEGG   DISEASE: 扁平苔癬
エントリ  
H01654                                                             
名称    
扁平苔癬
概要    
Lichen planus (LP) is a chronic inflammatory and immune mediated skin disease with characteristic clinical and histopathologic features. The skin and oral mucosa are the most frequently involved areas. Other mucous membranes (including the genitalia, esophagus, and conjunctiva) and skin appendages (e.g., scalp hair and nails) can also be affected. The etiology and pathogenesis of LP remain unclear. An autoimmune reaction in which CD8+-T lymphocytes attack basal keratinocytes leading to apoptosis of the cells has been favored. Various potential triggers, e.g. viral or bacterial antigens, metal ions, drugs or physical factors, could initiate the autoimmune process. Nonetheless, the role of the individual trigger factors is controversial. There is a significant association between lichen planus and infection with hepatitis C virus (HCV). The diagnosis of LP is based on the clinical presentation and should be confirmed by biopsy, if suspected. Histopathology is often conclusive, but in vesiculobullous cutaneous LP or erosive oral LP, direct immunofluorescence (DIF) studies can be an integral step in differentiating between LP and other diseases. With few exceptions, all forms of LP are treated with the same measures. Depending on the severity of the findings, topical and systemic treatment options are available.
カテゴリ  
皮膚および結合組織疾患; 免疫系疾患
階層分類  
ヒト疾患 [BR:jp08402]
 皮膚疾患
  皮膚と軟部組織の疾患
   H01654  扁平苔癬
ICD-11 による疾患分類 [BR:jp08403]
 14 皮膚の疾患
  炎症性皮膚症
   丘疹落屑性皮膚症
    EA91  扁平苔癬
     H01654  扁平苔癬
治療薬   
デキサメタゾン [DR:D00292]
デキサメタゾンリン酸エステルナトリウム [DR:D00975]
トリアムシノロンアセトニド [DR:D00983]
ベクロメタゾンプロピオン酸エステル [DR:D00689]
トリアムシノロン [DR:D00385]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
メチルプレドニゾロン [DR:D00407]
メチルプレドニゾロン酢酸エステル [DR:D00979]
デキサメタゾン吉草酸エステル [DR:D01948]
ベタメタゾン吉草酸エステル [DR:D01357]
アルクロメタゾンプロピオン酸エステル [DR:D01820]
アムシノニド [DR:D01387]
エトレチナート [DR:D00316]
リンク   
ICD-11: EA91
ICD-10: L43
MeSH: D008010
文献    
  著者
Le Cleach L, Chosidow O
  タイトル
Clinical practice. Lichen planus.
  雑誌
N Engl J Med 366:723-32 (2012)
DOI:10.1056/NEJMcp1103641
文献    
  著者
Gorouhi F, Davari P, Fazel N
  タイトル
Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis.
  雑誌
ScientificWorldJournal 2014:742826 (2014)
DOI:10.1155/2014/742826
文献    
  著者
Wagner G, Rose C, Sachse MM
  タイトル
Clinical variants of lichen planus.
  雑誌
J Dtsch Dermatol Ges 11:309-19 (2013)
DOI:10.1111/ddg.12031
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