KEGG   DISEASE: Social anxiety disorder
Entry
H01670                      Disease                                
Name
Social anxiety disorder;
Social phobia
Description
Social anxiety disorder (SAD) is the most common anxiety disorder. SAD is generally considered a chronic disorder and has its onset during early adolescence. It is a risk factor for subsequent depressive illness and substance abuse. Patients with SAD have an extreme fear of being negatively evaluated in social situations and, as a result, avoid social events or endure them with excessive fear or anxiety. Although the etiology of SAD is not yet fully established, twin and family studies suggest that SAD is heritable. Functional neuroimaging studies point to increased activity in amygdala and insula in patients with social anxiety disorder. In addition, there is evidence from various studies, that the serotonin, and dopamine neurotransmitter systems mediate the symptoms of SAD. A range of effective cognitive behavioural and pharmacological treatments now exists. However, they don't work for the 30-40% of patients.
Category
Mental and behavioural disorder
Brite
Human diseases [BR:br08402]
 Other diseases
  Mental and behavioural disorders
   H01670  Social anxiety disorder
Human diseases in ICD-11 classification [BR:br08403]
 06 Mental, behavioural or neurodevelopmental disorders
  Anxiety or fear-related disorders
   6B04  Social anxiety disorder
    H01670  Social anxiety disorder
Drug
Paroxetine hydrochloride hemihydrate [DR:D02260]
Paroxetine hydrochloride [DR:D05374]
Sertraline hydrochloride [DR:D00825]
Venlafaxine hydrochloride [DR:D00821]
Other DBs
ICD-11: 6B04
ICD-10: F40.1 F93.2
MeSH: D010698
Reference
  Authors
Stein MB, Stein DJ
  Title
Social anxiety disorder.
  Journal
Lancet 371:1115-25 (2008)
DOI:10.1016/S0140-6736(08)60488-2
Reference
  Authors
Bas-Hoogendam JM, Blackford JU, Bruhl AB, Blair KS, van der Wee NJA, Westenberg PM
  Title
Neurobiological candidate endophenotypes of social anxiety disorder.
  Journal
Neurosci Biobehav Rev 71:362-378 (2016)
DOI:10.1016/j.neubiorev.2016.08.040
Reference
  Authors
Lochner C, Hemmings S, Seedat S, Kinnear C, Schoeman R, Annerbrink K, Olsson M, Eriksson E, Moolman-Smook J, Allgulander C, Stein DJ
  Title
Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa.
  Journal
Eur Neuropsychopharmacol 17:321-7 (2007)
DOI:10.1016/j.euroneuro.2006.06.010
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