 | | DRUG: Venlafaxine hydrochloride | |
| Entry |
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| Name |
Venlafaxine hydrochloride (JAN/USP);
Effexor (TN) |
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| Product |
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| Generic |
VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (Ajanta Pharma USA), VENLAFAXINE (Alembic Pharmaceuticals Limited), VENLAFAXINE (Alembic Pharmaceuticals), VENLAFAXINE (American Health Packaging), VENLAFAXINE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE (Ascend Laboratories), VENLAFAXINE (Aurobindo Pharma Limited), VENLAFAXINE (BluePoint Laboratories), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Cadila Pharmaceuticals Limited), VENLAFAXINE (Cadila Pharmaceuticals Limited), VENLAFAXINE (Coupler LLC), VENLAFAXINE (Coupler LLC), VENLAFAXINE (Coupler LLC), VENLAFAXINE (Coupler LLC), VENLAFAXINE (Dr. Reddy's Laboratories), VENLAFAXINE (Edenbridge Pharmaceuticals LLC.), VENLAFAXINE (Golden State Medical Supply), VENLAFAXINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), VENLAFAXINE (Lannett Company), VENLAFAXINE (Modavar Pharmaceuticals LLC), VENLAFAXINE (Northwind Pharmaceuticals), VENLAFAXINE (Northwind Pharmaceuticals), VENLAFAXINE (Northwind Pharmaceuticals), VENLAFAXINE (Northwind Pharmaceuticals), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (PD-Rx Pharmaceuticals), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (Rising Pharma Holdings), VENLAFAXINE (ST. MARY'S MEDICAL PARK PHARMACY), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE (Sun Pharmaceutical Industries), VENLAFAXINE (Zydus Lifesciences Limited), VENLAFAXINE (Zydus Pharmaceuticals USA), VENLAFAXINE (Zydus Pharmaceuticals USA), VENLAFAXINE HCL (Advanced Rx Pharmacy of Tennessee), VENLAFAXINE HCL ER (Direct_Rx), VENLAFAXINE HCL ER (Direct_Rx), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (Advagen Pharma), VENLAFAXINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), VENLAFAXINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), VENLAFAXINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), VENLAFAXINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), VENLAFAXINE HYDROCHLORIDE (Advanced Rx of Tennessee), VENLAFAXINE HYDROCHLORIDE (Advanced Rx of Tennessee), VENLAFAXINE HYDROCHLORIDE (Advanced Rx of Tennessee), VENLAFAXINE HYDROCHLORIDE (Advanced Rx of Tennessee), VENLAFAXINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Alembic Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), VENLAFAXINE HYDROCHLORIDE (Annora Pharma Private Limited), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Ascent Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Asclemed USA), VENLAFAXINE HYDROCHLORIDE (Aurobindo Pharma Limited), VENLAFAXINE HYDROCHLORIDE (AvKARE), VENLAFAXINE HYDROCHLORIDE (AvPAK), VENLAFAXINE HYDROCHLORIDE (BluePoint Laboratories), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Camber Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Camber Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Cardinal Health 107), VENLAFAXINE HYDROCHLORIDE (Chartwell RX), VENLAFAXINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), VENLAFAXINE HYDROCHLORIDE (Dr.Reddy's Laboratories), VENLAFAXINE HYDROCHLORIDE (Dr.Reddys Laboratories), VENLAFAXINE HYDROCHLORIDE (Drug Ocean LLC), VENLAFAXINE HYDROCHLORIDE (Epic Pharma), VENLAFAXINE HYDROCHLORIDE (Granules Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Lannett Company), VENLAFAXINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Major Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NCS HealthCare of KY), VENLAFAXINE HYDROCHLORIDE (NCS HealthCare of KY), VENLAFAXINE HYDROCHLORIDE (Nivagen Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Northwind Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Nostrum Laboratories), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (QPharma), VENLAFAXINE HYDROCHLORIDE (QUALLENT PHARMACEUTICALS HEALTH LLC), VENLAFAXINE HYDROCHLORIDE (Quality Care Products), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (Rising Pharma Holdings), VENLAFAXINE HYDROCHLORIDE (St. Marys Medical Park Pharmacy), VENLAFAXINE HYDROCHLORIDE (Sun Pharmaceutical Industries), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Trigen Laboratories), VENLAFAXINE HYDROCHLORIDE (Vertical Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (XLCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Yaopharma), VENLAFAXINE HYDROCHLORIDE (Zydus Lifesciences Limited), VENLAFAXINE HYDROCHLORIDE (Zydus Lifesciences Limited), VENLAFAXINE HYDROCHLORIDE (Zydus Lifesciences Limited), VENLAFAXINE HYDROCHLORIDE (Zydus Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Zydus Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE, EXTENDED RELEASE (Edenbridge Pharmaceuticals LLC.) |
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| Formula |
C17H27NO2. HCl
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| Exact mass |
313.1809
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| Mol weight |
313.86
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00959): | D00821<JP/US> D12403<US> |
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| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
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| Disease |
Major depressive disorder [DS: H01646] Generalized anxiety disorder [DS: H01662] Social anxiety disorder [DS: H01670] Panic disorder [DS: H01664] |
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| Comment |
serotonin norepinephrine reuptake inhibitor (SNRI)
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX16 Venlafaxine
D00821 Venlafaxine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Venlafaxine
D00821 Venlafaxine hydrochloride (JAN/USP)
Anxiolytics
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Venlafaxine
D00821 Venlafaxine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00821 Venlafaxine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
DG00959 Venlafaxine
D00821 Venlafaxine hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00959 Venlafaxine
D00821 Venlafaxine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00959 Venlafaxine
D00821 Venlafaxine hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D00821 Venlafaxine hydrochloride (JAN/USP) <JP/US>
SLC6A4 (HTT)
D00821 Venlafaxine hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00821
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00821
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00821
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
DG00959 Venlafaxine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00959 Venlafaxine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00959 Venlafaxine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 X Cl 27.9676 -14.4620
2 C8x C 18.0600 -14.7700
3 C8y C 18.0600 -16.1700
4 C8x C 19.2724 -16.8700
5 C8x C 20.4849 -16.1700
6 C8y C 20.4849 -14.7700
7 C8x C 19.2724 -14.0700
8 C1x C 22.9097 -16.1700
9 C1z C 22.9097 -14.7700
10 C1c C 21.6973 -14.0700
11 C1x C 24.1222 -16.8700
12 C1x C 25.3346 -16.1700
13 C1x C 25.3346 -14.7700
14 C1x C 24.1222 -14.0700
15 O2a O 16.8476 -16.8700
16 C1a C 15.6521 -16.1796
17 C1b C 21.6973 -12.6700
18 O1a O 22.9097 -13.3700
19 N1c N 20.4869 -11.9712
20 C1a C 19.2924 -12.6610
21 C1a C 20.4868 -10.5702
BOND 21
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 8 9 1
8 9 10 1
9 6 10 1
10 8 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 9 14 1
15 3 15 1
16 15 16 1
17 10 17 1
18 9 18 1
19 17 19 1
20 19 20 1
21 19 21 1
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