KEGG   DISEASE: 社会不安障害
エントリ  
H01670                                                             
名称    
社会不安障害
概要    
Social anxiety disorder (SAD) is the most common anxiety disorder. SAD is generally considered a chronic disorder and has its onset during early adolescence. It is a risk factor for subsequent depressive illness and substance abuse. Patients with SAD have an extreme fear of being negatively evaluated in social situations and, as a result, avoid social events or endure them with excessive fear or anxiety. Although the etiology of SAD is not yet fully established, twin and family studies suggest that SAD is heritable. Functional neuroimaging studies point to increased activity in amygdala and insula in patients with social anxiety disorder. In addition, there is evidence from various studies, that the serotonin, and dopamine neurotransmitter systems mediate the symptoms of SAD. A range of effective cognitive behavioural and pharmacological treatments now exists. However, they don't work for the 30-40% of patients.
カテゴリ  
精神及び行動の障害
階層分類  
ヒト疾患 [BR:jp08402]
 その他の疾患
  精神及び行動の障害
   H01670  社会不安障害
ICD-11 による疾患分類 [BR:jp08403]
 06 精神, 行動, 神経発達の障害
  不安または恐怖関連症
   6B04  社交不安症
    H01670  社会不安障害
治療薬   
パロキセチン塩酸塩水和物 [DR:D02260]
フルボキサミンマレイン酸塩 [DR:D00824]
エスシタロプラムシュウ酸塩 [DR:D02567]
リンク   
ICD-11: 6B04
ICD-10: F40.1 F93.2
MeSH: D010698
文献    
  著者
Stein MB, Stein DJ
  タイトル
Social anxiety disorder.
  雑誌
Lancet 371:1115-25 (2008)
DOI:10.1016/S0140-6736(08)60488-2
文献    
  著者
Bas-Hoogendam JM, Blackford JU, Bruhl AB, Blair KS, van der Wee NJA, Westenberg PM
  タイトル
Neurobiological candidate endophenotypes of social anxiety disorder.
  雑誌
Neurosci Biobehav Rev 71:362-378 (2016)
DOI:10.1016/j.neubiorev.2016.08.040
文献    
  著者
Lochner C, Hemmings S, Seedat S, Kinnear C, Schoeman R, Annerbrink K, Olsson M, Eriksson E, Moolman-Smook J, Allgulander C, Stein DJ
  タイトル
Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa.
  雑誌
Eur Neuropsychopharmacol 17:321-7 (2007)
DOI:10.1016/j.euroneuro.2006.06.010
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