Sudden cardiac death resulting from ventricular tachyarrhythmia represents a major healthcare issue. Familial ventricular tachycardia is usually attributable to recognized conditions such as arrhythmogenic right ventricular dysplasia, hypertrophic cardiomyopathy, familial cardiomyopathy or one of the long QT interval syndromes. However, some patients had no specific electrocardiographic (ECG) changes. Their QT intervals were normal and showed no cardiac abnormalities. It has been reported that absence of the inhibitory G-Protein (G alpha i-2) predisposes to ventricular tachycardia.
