KEGG   DISEASE: Fulminant viral hepatitis
Entry
H02591                      Disease                                
Name
Fulminant viral hepatitis
  Supergrp
Fulminant hepatic failure [DS:H01712]
Description
Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH caused by inborn errors in IL18BP have been reported. IL18BP encodes IL-18 binding protein. IL18BP is the naturally occurring antagonist of IL-18.
Category
Immune system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 04 Diseases of the immune system
  Autoinflammatory disorders
   4A60  Monogenic autoinflammatory syndromes
    H02591  Fulminant viral hepatitis
Gene
IL18BP [HSA:10068] [KO:K25565]
Other DBs
ICD-11: 4A60
MeSH: D056660
OMIM: 618549
Reference
PMID:31213488
  Authors
Belkaya S, Michailidis E, Korol CB, Kabbani M, Cobat A, Bastard P, Lee YS, Hernandez N, Drutman S, de Jong YP, Vivier E, Bruneau J, Beziat V, Boisson B, Lorenzo-Diaz L, Boucherit S, Sebagh M, Jacquemin E, Emile JF, Abel L, Rice CM, Jouanguy E, Casanova JL
  Title
Inherited IL-18BP deficiency in human fulminant viral hepatitis.
  Journal
J Exp Med 216:1777-1790 (2019)
DOI:10.1084/jem.20190669
Reference
PMID:34699263
  Authors
Rood JE, Behrens EM
  Title
Inherited Autoinflammatory Syndromes.
  Journal
Annu Rev Pathol 17:227-249 (2022)
DOI:10.1146/annurev-pathmechdis-030121-041528
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