KEGG   DISEASE: Menstrual cycle-dependent periodic fever
Entry
H02773                      Disease                                
Name
Menstrual cycle-dependent periodic fever
Description
Menstrual cycle-dependent periodic fever (PFMCD) is a rare disease characterized by recurrent high fever with each menstrual cycle. It has been reported mutations in HTR1A cause this disease. HTR1A encodes the serotonin receptor 1A that plays a critical role in serotonergic transmission.
Category
Endocrine and metabolic disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Endocrine diseases
   5B3Y  Other specified endocrine diseases
    H02773  Menstrual cycle-dependent periodic fever
Pathway-based classification of diseases [BR:br08402]
 Cellular process
  nt06544  Neuroactive ligand signaling
   H02773  Menstrual cycle-dependent periodic fever
Pathway
hsa04726  Serotonergic synapse
hsa04082  Neuroactive ligand signaling
Network
nt06544 Neuroactive ligand signaling
Gene
HTR1A [HSA:3350] [KO:K04153]
Other DBs
ICD-11: 5B3Y
OMIM: 614674
Reference
PMID:21990073
  Authors
Jiang YC, Wu HM, Cheng KH, Sunny Sun H
  Title
Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human  serotonin receptor 1A gene.
  Journal
Hum Mutat 33:209-17 (2012)
DOI:10.1002/humu.21622
LinkDB

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