Seborrheic keratosis is one of the most common benign epidermal tumors that associates with increased age. The lesions manifest clinically as acquired, well-demarcated brownish papules or plaques with a verrucous surface that predominantly localize at areas of the head, neck and trunk. Seborrheic keratoses harbor multiple somatic alterations. Despite the lack of malignant potential, most of the lesions carry at least one mutation in a well-characterized oncogene. It has been reported that oncogenic PIK3CA mutations occur in epidermal nevi [DS:H02627] and seborrheic keratoses.
Hafner C, Lopez-Knowles E, Luis NM, Toll A, Baselga E, Fernandez-Casado A, Hernandez S, Ribe A, Mentzel T, Stoehr R, Hofstaedter F, Landthaler M, Vogt T, Pujol RM, Hartmann A, Real FX
タイトル
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.
