KEGG   ORTHOLOGY: K00025
Entry
K00025                      KO                                     

Symbol
MDH1
Name
malate dehydrogenase [EC:1.1.1.37]
Pathway
map00020  Citrate cycle (TCA cycle)
map00270  Cysteine and methionine metabolism
map00620  Pyruvate metabolism
map00630  Glyoxylate and dicarboxylate metabolism
map00710  Carbon fixation in photosynthetic organisms
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map04964  Proximal tubule bicarbonate reclamation
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00012  Glyoxylate cycle
M00168  CAM (Crassulacean acid metabolism), dark
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00025  MDH1; malate dehydrogenase
   00620 Pyruvate metabolism
    K00025  MDH1; malate dehydrogenase
   00630 Glyoxylate and dicarboxylate metabolism
    K00025  MDH1; malate dehydrogenase
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00025  MDH1; malate dehydrogenase
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K00025  MDH1; malate dehydrogenase
 09150 Organismal Systems
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    K00025  MDH1; malate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     K00025  MDH1; malate dehydrogenase
Other DBs
RN: R00342 R07136
GO: 0030060
Genes
HSA: 4190(MDH1)
PTR: 459271(MDH1)
PPS: 100977785(MDH1)
GGO: 101134761(MDH1)
PON: 100454132(MDH1)
NLE: 100581689(MDH1)
MCC: 694703(MDH1)
MCF: 101865736(MDH1)
CSAB: 103220175(MDH1)
CATY: 105576458(MDH1)
PANU: 101019100(MDH1)
RRO: 104669214(MDH1)
RBB: 108517135(MDH1)
TFN: 117099720(MDH1)
PTEH: 111550617(MDH1)
CJC: 100402890(MDH1)
SBQ: 101040730(MDH1)
MMUR: 105871518(MDH1)
MMU: 17449(Mdh1)
MCAL: 110304226(Mdh1)
MPAH: 110330437(Mdh1)
RNO: 24551(Mdh1)
MCOC: 116071128(Mdh1)
CGE: 100764352(Mdh1)
PLEU: 114697941(Mdh1)
NGI: 103748091(Mdh1)
HGL: 101719728(Mdh1)
CCAN: 109685017(Mdh1) 109701612
OCU: 100341412(MDH1)
TUP: 102501679(MDH1)
CFA: 474614(MDH1)
VVP: 112915291(MDH1)
VLG: 121490979(MDH1)
AML: 100482261(MDH1)
UMR: 103671312(MDH1)
UAH: 113245054(MDH1)
ORO: 101376601(MDH1)
ELK: 111147900
MPUF: 101676248(MDH1)
EJU: 114198302(MDH1)
MLX: 118008069(MDH1)
FCA: 493924(MDH1)
PYU: 121019114(MDH1)
PTG: 102951622(MDH1)
PPAD: 109258189(MDH1) 109271927
AJU: 106973479(MDH1)
HHV: 120239064(MDH1)
BTA: 535182(MDH1)
BOM: 102270407(MDH1)
BIU: 109566205(MDH1)
BBUB: 102388969(MDH1)
CHX: 102176699(MDH1)
OAS: 101116035(MDH1)
ODA: 120851335(MDH1)
CCAD: 122441825(MDH1)
SSC: 396894(MDH1)
CFR: 102516914(MDH1)
CBAI: 105066546(MDH1)
CDK: 105101816(MDH1)
BACU: 103016557(MDH1)
LVE: 103076659(MDH1)
OOR: 101288343(MDH1)
DLE: 111186590(MDH1)
PCAD: 102992090(MDH1)
ECB: 100051612(MDH1)
EPZ: 103561022(MDH1)
EAI: 106828371(MDH1)
MYB: 102253671(MDH1)
MYD: 102758532(MDH1)
MMYO: 118668948(MDH1)
MNA: 107545961(MDH1)
HAI: 109378994(MDH1)
DRO: 112297883(MDH1)
SHON: 118988430(MDH1)
AJM: 119035043(MDH1) 119037016
MMF: 118630993(MDH1)
PALE: 102878302(MDH1)
PGIG: 120621590(MDH1)
RAY: 107519878(MDH1)
MJV: 108402755(MDH1)
TOD: 119258991(MDH1)
LAV: 100665411(MDH1)
TMU: 101349161
MDO: 100031872(MDH1)
SHR: 100925139(MDH1)
PCW: 110207709(MDH1)
OAA: 100082315(MDH1)
GGA: 421281(MDH1)
PCOC: 116232707(MDH1)
MGP: 100539955(MDH1)
CJO: 107310702(MDH1)
NMEL: 110395788(MDH1)
APLA: 101794999(MDH1)
ACYG: 106045616(MDH1)
TGU: 100190381
LSR: 110484874(MDH1)
SCAN: 103821392(MDH1)
PMOA: 120506819(MDH1)
GFR: 102043811(MDH1)
FAB: 101814527(MDH1)
PHI: 102108399(MDH1)
PMAJ: 107202297(MDH1)
CCAE: 111926540(MDH1)
CCW: 104696612(MDH1)
ETL: 114064802(MDH1)
FPG: 101913475(MDH1)
FCH: 102046600(MDH1)
CLV: 102084654(MDH1)
EGZ: 104129206(MDH1)
NNI: 104014929(MDH1)
ACUN: 113477723(MDH1)
PADL: 103919583(MDH1)
AAM: 106499922(MDH1)
NPD: 112942924(MDH1)
ASN: 102372118(MDH1)
AMJ: 102566997(MDH1)
CPOO: 109319553(MDH1)
GGN: 109296952(MDH1)
PSS: 102463290(MDH1)
CMY: 102938108(MDH1)
CPIC: 101947638(MDH1)
TST: 117874260(MDH1)
CABI: 116815166(MDH1)
ACS: 100553622(mdh1)
PVT: 110084218(MDH1)
PBI: 103058397(MDH1)
PMUR: 107284309(MDH1)
TSR: 106541542(MDH1)
PGUT: 117674460(MDH1)
PMUA: 114593506(MDH1)
ZVI: 118082656(MDH1)
GJA: 107120025(MDH1)
XLA: 108716589(mdh1.L) 398872(mdh1.S)
XTR: 448318(mdh1)
NPR: 108786327(MDH1)
DRE: 335715(mdh1ab) 399662(mdh1aa)
PHYP: 113537366(mdh1) 113544999
TRU: 101072315 101073761(mdh1)
LCO: 104918526(mdh1) 104931836
NCC: 104942001(mdh1) 104942739
CGOB: 115013278(mdh1) 115020293
ELY: 117248727(mdh1ab) 117255683
PLEP: 121954839(mdh1ab)
SLUC: 116052168 116061686(mdh1ab)
ECRA: 117952219 117960206(mdh1ab)
PFLV: 114566991(mdh1) 114571688
CUD: 121508515 121511355(mdh1ab)
OLA: 100049475(mdhb) 100302445(mdh1)
OML: 112157096 112161617(mdh1ab)
XMA: 102234083(mdh1) 102234452
XHE: 116713526 116719759(mdh1)
CTUL: 119778669 119798098(mdh1ab)
KMR: 108242660(mdh1ab) 108247105
ALIM: 106526766(mdh1) 106536176
SDU: 111227419 111232961(mdh1)
XGL: 120796014(mdh1ab) 120800474
MALB: 109952294(mdh1) 109961149
SASA: 106564857(MDHC) 106577387 106577388(mdh1b) 106585868(MDHC) 106593044(MDHC) 106596468
OTW: 112230370
ELS: 105008309 105021528(mdh1)
AANG: 118217892(mdh1ab) 118221616
LOC: 102697061(mdh1)
ARUT: 117402977 117411155(mdh1ab)
LCM: 102357680(MDH1)
CMK: 103172058 103177941(mdh1)
RTP: 109920559(mdh1) 109924103
BFO: 118417865
BBEL: 109474855
CIN: 100187217
SCLV: 120329060
SPU: 591635
APLC: 110976738
SKO: 100375508
DME: Dmel_CG5362(Mdh1)
DER: 6542444
DSI: Dsimw501_GD22263(Dsim_GD22263)
DSR: 110183273
DPE: 6588726
DMN: 117188620
DWI: 6653335
DGR: 6567098
DAZ: 108609696
DNV: 108657985
DHE: 111594730
MDE: 101889109
LCQ: 111676607
ACOZ: 120959759
AARA: 120905161
AAG: 5569520
AALB: 109411704
CPII: 120419078
CCAL: 108631581
OBB: 114872634
SOC: 105204759
MPHA: 105838367
AEC: 105146275
ACEP: 105620456
PBAR: 105424381
VEM: 105566268
HST: 105188233
DQU: 106742320
CFO: 105258207
FEX: 115239545
LHU: 105671860
PGC: 109853049
OBO: 105287655
PCF: 106788153
CSOL: 105360230
MDL: 103578641
TCA: 664447
DPA: 109544302
ATD: 109606052
AGB: 108917464
LDC: 111505613
NVL: 108556428
PPYR: 116167877
OTU: 111423720
BMOR: 692952
BANY: 112044575
PPOT: 106101978
ZCE: 119834232
PXY: 105383268
DNX: 107170335
AGS: 114126714
BTAB: 109032252
CLEC: 106667067
HHAL: 106678815
NLU: 111059929
ZNE: 110834552
CSEC: 111874998
FCD: 110845081
DPX: DAPPUDRAFT_308915(MDHC)
DMK: 116928455
PVM: 113820410
HAME: 121858877
HAZT: 108671277
EAF: 111715965
VDE: 111250502
VJA: 111262741
TUT: 107364466
DPTE: 113790507
CSCU: 111637826
PTEP: 107447971
SDM: 118185743
CEL: CELE_F46E10.10(mdh-1)
CBR: CBG18957
BMY: BM_BM4147(Bma-mdh-1)
TSP: Tsp_08379
PCAN: 112570511
CRG: 105343888
MYI: 110456733
PMAX: 117323963
OBI: 106879647
LAK: 106154959
NVE: 5512984
EPA: 110243790
ATEN: 116288374
ADF: 107337641
AMIL: 114956349
PDAM: 113667217
DGT: 114520069
HMG: 100208718
AQU: 100639823
ATH: AT1G04410(c-NAD-MDH1) AT5G43330(c-NAD-MDH2) AT5G56720(c-NAD-MDH3)
CPAP: 110815859
LJA: Lj3g3v3752070.2(Lj3g3v3752070.2) Lj5g3v1201280.1(Lj5g3v1201280.1) Lj6g3v0028890.1(Lj6g3v0028890.1)
SLY: 101253131 778330(cMDH)
BVG: 104887939(nr1) 104905328
DOSA: Os04t0551200-01(Os04g0551200) Os10t0478200-01(Os10g0478200)
ATS: 109742567
PEQ: 110031066
PPP: 112273839
APRO: F751_0245
DDI: DDB_G0280255(mdhC) DDB_G0290207(mdhA)
DFA: DFA_04718(mdhC) DFA_10949(mdhA)
EHI: EHI_030810(195.t00006) EHI_152670(24.t00003)
SPAR: SPRG_09101
LMA: LMJF_28_2860(cMDH)
LIF: LINJ_28_3090(cMDH)
LBZ: LBRM_28_3070(cMDH)
LPAN: LPMP_283010(CMDH)
 » show all
Reference
PMID:8786100
  Authors
Tanaka T, Inazawa J, Nakamura Y
  Title
Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase (MDH1).
  Journal
Genomics 32:128-30 (1996)
DOI:10.1006/geno.1996.0087
  Sequence
[hsa:4190]
Reference
PMID:3052244
  Authors
Friedrich CA, Ferrell RE, Siciliano MJ, Kitto GB
  Title
Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes.
  Journal
Ann Hum Genet 52:25-37 (1988)
DOI:10.1111/j.1469-1809.1988.tb01075.x
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