KEGG   ORTHOLOGY: K00189
Entry
K00189                      KO                                     
Symbol
vorG, porG
Name
2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00020  Citrate cycle (TCA cycle)
map00280  Valine, leucine and isoleucine degradation
map00620  Pyruvate metabolism
map00633  Nitrotoluene degradation
map00640  Propanoate metabolism
map00650  Butanoate metabolism
map00680  Methane metabolism
map00720  Other carbon fixation pathways
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01210  2-Oxocarboxylic acid metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Reaction
R01196  pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
R01199  2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propanoylating)
R07160  3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating;CoA-2-methylpropanoylating)
R08034  
R08566  4-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-3-methylbutanoylating)
R08567  (S)-3-methyl-2-oxopentanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylbutanoylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00020 Citrate cycle (TCA cycle)
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00620 Pyruvate metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00640 Propanoate metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00650 Butanoate metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
  09102 Energy metabolism
   00720 Other carbon fixation pathways
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
   00680 Methane metabolism
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
  09111 Xenobiotics biodegradation and metabolism
   00633 Nitrotoluene degradation
    K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.1  pyruvate synthase
     K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
    1.2.7.7  3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
     K00189  vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid oxidizing enzymes
  K00189
Other DBs
COG: COG1014
GO: 0043807 0019164
Genes
HMR: Hipma_0796
DAV: DESACE_01545
DBK: DGMP_23530
DEK: DSLASN_10380
DAW: HS1_001571(porC)
AORY: AMOR_34150
DHR: LGS26_04510
CALK: HUE98_02340
MPAG: C0J29_14490
LMAJ: GKN94_01220
PFU: PF0971
PFI: PFC_04085
PHO: PH0678(PH0678)
PAB: PAB1470
PYN: PNA2_1292
PYA: PYCH_06660
PYS: Py04_1082
PYC: TQ32_04845
TKO: TK1978
TON: TON_1476
TGA: TGAM_0267(porG)
TSI: TSIB_1384
TBA: TERMP_01560
THE: GQS_08140
THA: TAM4_1107
THM: CL1_1249
TLT: OCC_07501
THS: TES1_1555
TNU: BD01_1941
TEU: TEU_01685
TGY: X802_03775
THV: ADU37_CDS14470
TCH: CHITON_0665
TPEP: A0127_04995
TPIE: A7C91_04910
TGG: A3K92_07955
TCE: A3L02_06815
TBS: A3L01_08180
THH: CDI07_07400
TSL: A3L11_01530
TTD: A3L14_10575
TPRF: A3L09_01305
TRL: A3L10_07570
TPAF: A3L08_01305
THY: A3L12_04015
TIC: FH039_11775
TCQ: TIRI35C_1959(porG)
THEM: FPV09_09760
THEI: K1720_10015
PPAC: PAP_04300
MAQE: RJ40_07300
MFK: E2N92_07470
HAHS: HSRCO_0562(porG)
TAC: Ta0626
ABI: Aboo_0298
ACF: AciM339_0766
IPC: IPA_03975
PABI: PABY_00170
PARE: PYJP_01300
FLT: Sv326_0312
LOB: NEF87_002291 NEF87_002419
PSYT: DSAG12_00810
AGW: QT03_C0001G0327
 » show all
Reference
PMID:8550513 (P.furiosus)
  Authors
Heider J, Mai X, Adams MW
  Title
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.
  Journal
J Bacteriol 178:780-7 (1996)
DOI:10.1128/JB.178.3.780-787.1996
Reference
PMID:8550425
  Authors
Kletzin A, Adams MW
  Title
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.
  Journal
J Bacteriol 178:248-57 (1996)
DOI:10.1128/JB.178.1.248-257.1996
  Sequence
[pfu:PF0971]
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