Entry
Name
7-dehydrocholesterol reductase;
DHCR7 (gene name);
7-DHC reductase;
7-dehydrocholesterol dehydrogenase/cholesterol oxidase;
Delta7-sterol reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cholesterol:NADP+ Delta7-oxidoreductase
Reaction(IUBMB)
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN:
R01456 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme is part of the cholesterol biosynthesis pathway.
History
EC 1.3.1.21 created 1972, modified 2013
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K00213 7-dehydrocholesterol reductase
Genes
PMUR : 107294554 107294556 107294557
CTIG : 120316163 120316165
PMUA : 114596913 114596955
XLA : 379273(dhcr7.S) 380248(dhcr7.L)
SRX : 107727115(dhcr7) 107730061
SANH : 107679738 107686818
CCAR : 109103437 109103439
CAUA : 113052398 113106502(dhcr7)
MASI : 127414967 127440584
TNG : GSTEN00019198G001 GSTEN00019199G001
SASA : 106562054(dhcr7) 106587139
STRU : 115167486 115202959
ONE : 115112100 115113560(dhcr7)
SALP : 111969284 111974247
CCLU : 121573333 121582316
PSPA : 121294271 121330286
ARUT : 117432415 117435021
BTAB : 109033727 109040108
PPOI : 119093227 119093228 119093748
DSV : 119461006 119461010 119462124 119462125 119465009 119465134
RSAN : 119378567 119396498 119396499 119397514
RMP : 119174557 119174682 119174683
CSCU : 111636841 111636843
PCAN : 112574082 112574092
BGT : 106053689 106067257 106067259 106068985 106071865
PMAX : 117326295 117328004
MMER : 123525122 123533770
RPHI : 132725325 132737374 132737377 132752645
DPOL : 127853110 127861466 127862103 127862104 127862105 127862107
MAEA : 128213071 128215561 128230743
CSAT : 104742576 104758352 104777974
RSZ : 108848514 108848528 108859250
MSYL : 126612363 126634227
PALZ : 118045106 118060206
SPEN : 107008408 107023649
SOT : 102589505 102604909(StDWF5)
SSTN : 125872987 125873602
SDUL : 129887626 129898764
CANN : 107845860 107875679
SSPL : 121797430 121801269
PSOM : 113298913 113298926 113358687
TAES : 123063456 123072467 123080701
MFLO : 136463303 136473573 136473592
PVIR : 120655686 120700873
ZOF : 122027064 122029360 122031900 122034394
SMO : SELMODRAFT_135440(DWF5-2) SELMODRAFT_185064(DWF5-1)
FOX : FOXG_12967 FOXG_16578
CDET : 87949448(CDEST_12948)
PSCO : LY89DRAFT_698617 LY89DRAFT_746866
AOR : AO090001000167 AO090003000792 AO090010000319 AO090010000690
AFV : AFLA_000891 AFLA_008510 AFLA_013802 AFLA_014184
APUU : APUU_22197A APUU_40100A
FFU : CLAFUR5_03217 CLAFUR5_09494
LJR : NCTC11533_02823(DWF)
LCJ : NCTC11976_02540(DWF)
» show all
Taxonomy
Reference
Authors
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.
Title
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS.
Journal
J Biol Chem 239:1381-7 (1964)
Reference
Authors
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H
Title
Molecular cloning and expression of the human delta7-sterol reductase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.21
ExPASy - ENZYME nomenclature database: 1.3.1.21
LinkDB
All DBs