KEGG ORTHOLOGY: K00488

ORTHOLOGY: K00488

Entry

K00488                      KO

Symbol

CYP27A1

Name

cholestanetriol 26-monooxygenase [EC:1.14.15.15]

Pathway

map00120

Primary bile acid biosynthesis

map01100

Metabolic pathways

map03320

PPAR signaling pathway

map04979

Cholesterol metabolism

Module

M00104

Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate

Reaction

R04806

R04807

R08505

cholesterol 26-hydroxylase

R08758

R08759

R08760

R08761

R11142

5beta-cholestane-3alpha,7alpha,12alpha-triol,adrenodoxin:oxygen oxidoreductase (26-hydroxylating)

Disease

H00151

Cerebrotendinous xanthomatosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
  09154 Digestive system
   04979 Cholesterol metabolism
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.15  cholestanetriol 26-monooxygenase
     K00488  CYP27A1; cholestanetriol 26-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP27 family
   K00488  CYP27A1; cholestanetriol 26-monooxygenase

Other DBs

GO:

0047749

Genes

HSA:	1593(CYP27A1)

PTR:

459951

PPS:	100989602(CYP27A1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	700192(CYP27A1)

MCF:	102129822(CYP27A1)

MTHB:

126932993

MNI:

105481230

CSAB:

103217882(CYP27A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100393783(CYP27A1)

SBQ:

101029011

CIMI:

108309072(CYP27A1)

ANAN:

105712887(CYP27A1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	104086(Cyp27a1)

MCAL:

110290578

MPAH:

110322436

RNO:	301517(Cyp27a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100348736(CYP27A1)

OPI:

101518668

TUP:

102471009

GVR:

103600243

CFA:	610489(CYP27A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101091962(CYP27A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	511960(CYP27A1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	100126282(CYP27A1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100055936(CYP27A1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:	101411078 101411838 101423385

MDO:	100011045(CYP27A1)

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

GGA:	431683(CYP27A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106039314(CYP27A1)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136363597(CYP27A1)

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HLE:

AGEN:

GCL:

CSTI:

LDI:

MNB:

AVIT:

EGZ:

NNI:

PCRI:

PADL:

AFOR:

FGA:

CLV:

MUI:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:

CPOO:

GGN:

CMY:

CCAY:

DCC:

CPIC:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:	128340098 128340957

GJA:	107116962 107122111

STOW:

125425853 125427460

EMC:	129323825 129323969

XLA:	100381137(cyp27a1) 108702937 446987(XB984297.L)

XTR:	100145331 100496109 116407844 594905

NPR:	108783869 108783870 108783871 108783872 108783878 108783885

RTEM:

120944205 120944206 120944214

BBUF:

121007459 121007461 121008616

BGAR:

122944797 122944805 122945772

MUO:

115474647

DRE:	322341(cyp27a1.4) 402831(cyp27a1.1) 558239(cyp27a2) 565876(cyp27a3) 723999(zgc:136333) 795106(cyp27a1.2)

SRX:	107705485 107706665 107714212 107723676 107725254 107741910

SANH:

107658292 107659991 107660625 107660626 107677609 107683415

SGH:	107555015 107555356 107555927 107578255 107581419 107584802 107596087

CCAR:

109064887 109072531 109088722 109088733 109088804 109096773 109113433

CAUA:

113050872 113053045 113053331 113092289 113108126 113108393 113108395 113108503

CGIB:

127959978(si:ch211-113j14.1) 127964813 127965339 128016157 128019738 128020024

PTET:

122346890(si:ch211-113j14.1) 122351411(si:dkey-91i10.3) 122351848 122351850

LROH:

127166631 127171000 127171002 127171405

OMC:	131542011 131546658 131547049 131547580

PPRM:

120461532 120461533 120466971(si:dkey-91i10.3) 120491553(si:ch211-113j14.1)

RKG:	130085900 130096620 130096621 130101313

MAMB:

125270463(si:dkey-91i10.3) 125270558 125270559 125270561 125270562 125274236(si:ch211-113j14.1)

CIDE:

127514128(si:ch211-113j14.1) 127518365 127518366 127518368(si:dkey-91i10.3) 127518425

CERY:

137011746(cyp27a2) 137035621 137035858 137035919 137036502(cyp27a3)

MASI:

127446272(si:ch211-113j14.1) 127447105(si:dkey-91i10.3) 127447172 127448309 127448847

TROS:

130555464 130556084 130556649

TDW:	130424684 130427058 130427607

MANU:

129451170 129451484 129452197 129452198

IPU:	108261037 108261972 108266489 108266490 108266491 108272717(si:ch211-113j14.1) 124627672

IFU:	128608666 128609022 128609023 128609024 128615288

PHYP:

113526131 113526132 113526133 113526134 113526210 113526267 113538157

SMEO:

124380536 124382704 124383131 124383132 124383214(si:dkey-91i10.3) 124392227(si:ch211-113j14.1)

TFD:	113651034(si:ch211-113j14.1) 113654303 113654508(si:dkey-91i10.3) 113654626

TVC:	132844928 132850104 132850336 132850337

TRN:	134317294 134323918 134324263

AMEX:

103023980 103024291 103027002(si:ch211-113j14.1) 103036363(si:dkey-91i10.3)

CMAO:

118807247 118807846(si:ch211-113j14.1) 118824141(si:dkey-91i10.3)

EEE:	113567700 113577222 113586367

CHAR:

105892637(si:ch211-113j14.1) 105907897 105912667(si:dkey-91i10.3)

TRU:	101062671 101063777 101069976

TFS:	130522346 130530915 130534294

TNG:	GSTEN00029207G001

LCO:	104934615 104939434 109141591

NCC:	104944399 104954736 104955625

TBEN:

117485949 117495315(si:dkey-91i10.3) 117499195(si:ch211-113j14.1)

CGOB:

115017336 115026484 115026794

PGEO:

117441076 117466440(si:dkey-91i10.3) 117466930

GACU:

117533149(si:ch211-113j14.1) 117538127(si:dkey-91i10.3) 117549511

EMAC:

134860628 134867093 134867838

ELY:	117249878(si:ch211-113j14.1) 117251494(si:dkey-91i10.3) 117251800

EFO:	125884826(si:ch211-113j14.1) 125899310(si:dkey-91i10.3) 125899964

PLEP:

121949258(si:dkey-91i10.3) 121949317 121962951(si:ch211-113j14.1)

SLUC:

116033996(si:dkey-91i10.3) 116044772(si:ch211-113j14.1)

ECRA:

117939647(si:ch211-113j14.1) 117952801(si:dkey-91i10.3)

ESP:	116673863 116697553

PFLV:

114550996 114564588

GAT:	120814973 120814975 120834098

PPUG:

119220421(si:ch211-113j14.1) 119228308 119228466(si:dkey-91i10.3)

AFB:	129104391 129104777 129111512

CLUM:

117741891(si:ch211-113j14.1) 117750380 117750467(si:dkey-91i10.3)

PSWI:

130204495 130207217 130208830

MSAM:

119900367(si:ch211-113j14.1) 119903811 119904427(si:dkey-91i10.3)

SCHU:

122871830(si:ch211-113j14.1) 122885091(si:dkey-91i10.3) 122886090

CUD:	121506513(si:ch211-113j14.1) 121522777 121522982(si:dkey-91i10.3)

ALAT:

119015239(si:ch211-113j14.1) 119025758(si:dkey-91i10.3) 119026140

MZE:	101465003 101473743 101478374

ONL:	100691854 100693469 100705229

OAU:	116314781(si:dkey-91i10.3) 116317150(si:ch211-113j14.1) 116334070

OLA:	101156051 101160538 101175691

OML:	112154786 112155582(si:dkey-91i10.3) 112156772(si:ch211-113j14.1)

CSAI:

133425196 133445710 133446096

XMA:	102225514 102230910 102234678 102234938

XCO:	114140560 114147791 114147794 114148371

XHE:	116715672 116722946 116723684 116723685

PRET:

103456753 103461862 103461863 103478550

PFOR:

103134814 103138135 103154130

PLAI:

106945401 106945403 106949526 106956502

PMEI:

106916312 106919596 106926480

GAF:	122826962 122840052 122840053 122840415(si:dkey-91i10.3)

PPRL:

129355976 129360843 129374479 129374480

CVG:	107086204 107086205 107095844 107096820

CTUL:

119774007 119774012 119778495(si:dkey-91i10.3) 119794638(si:ch211-113j14.1)

GMU:	124861938(si:ch211-113j14.1) 124870981 124871015 124871107(si:dkey-91i10.3)

NFU:	107384645 107389662 107396451

KMR:	108238813(si:dkey-91i10.3) 108244283

ALIM:

106511198 106511262 106514257 106532599

NWH:	119419001 119419472(si:dkey-91i10.3) 119429051(si:ch211-113j14.1)

AOCE:

111562629 111568532 111571431 111574457

MCEP:

125000998 125018222(si:dkey-91i10.3) 125018282

CSEM:

103380768 103389542

POV:	109637350 109640203 109641449

SSEN:

122765461(si:ch211-113j14.1) 122783812 122784640(si:dkey-91i10.3)

HHIP:

117755070(si:dkey-91i10.3) 117755238 117778068(si:ch211-113j14.1)

HSP:	118103627(si:ch211-113j14.1) 118120133 118120203(si:dkey-91i10.3)

PPLT:

128431228 128456409 128456410 128456474

SMAU:

118282520(si:dkey-91i10.3) 118283128 118299537(si:ch211-113j14.1)

LCF:	108873048(si:ch211-113j14.1) 108897118(si:dkey-91i10.3) 108897170

SDU:	111218457 111218691 111222696

SLAL:

111653799 111667407 111672420

XGL:	120798148(si:ch211-113j14.1) 120801357(si:dkey-91i10.3) 120801379

HCQ:	109517561 109519132 109528391

SSCV:

125973467 125973998(si:dkey-91i10.3) 125988453(si:ch211-113j14.1)

SBIA:

133507117 133511790 133512247

PEE:	133403915 133410410 133410778

PTAO:

133480720 133486533 133486856

BPEC:

110165678 110166041 110171370

MALB:

109955654 109972640 109974026

BSPL:

114845813(si:ch211-113j14.1) 114846707 114846743(si:dkey-91i10.3)

SJO:	128354620 128367942 128368386

SASA:

106574240 106575170 106586130 106586420 106586421

STRU:

115156161 115160652 115160949 115160950 115179454 115196033

OTW:	112225125 112235263 112238608(si:dkey-91i10.3) 112253824 112266509

OMY:	110495869 110501573 110520006 110520277(si:dkey-91i10.3) 110527483

OGO:	124008274 124010863 124041765 124043781 124043995(si:dkey-91i10.3)

ONE:	115107908 115110822 115129706 115133470 115136440

OKI:	109865639 109868100 109870843 109878202 109906858

OKE:	118363755 118366908 118367168 118370220 118385931

SALP:

111953394 111959818 111970920 111973814

SNH:	120033627(si:ch211-113j14.1) 120050736 120058201 120058325 120058328 120064454

CCLU:

121536654 121537015 121548322 123481257

ELS:	105016129 105016181 105019951

SFM:	108928920 108936404

PKI:	111840728 111851734

AANG:

118214017(si:ch211-113j14.1) 118222144(si:dkey-91i10.3) 118222523 118223580

LOC:	102687850 102689682 102690084 102695871

PSPA:

121322499 121323017 121323418 121323529(si:dkey-91i10.3)

ARUT:

117404073 117408072 117411922 117426218

PSEX:

120530726(si:dkey-91i10.3) 120531223 120531279(si:ch211-113j14.1)

LCM:	102347924 102352926 102355859(EAF2) 102357152

CMK:	103189020(si:dkey-91i10.3)

RTP:	109912644(si:dkey-91i10.3) 109924020

CPLA:

122551787(si:dkey-91i10.3) 122551956

HOC:	132817700 132817724

LERI:

129693908

PMRN:

116938626 116940874

LRJ:	133344490 133344639 133346016

BBEL:

109482768

LPIC:

129255121

GAE:	121371591 121371592 121372413

HRJ:	124282300 124282301

OED:

LLON:

ATEN:

Reference

PMID:1708392

Authors

Cali JJ, Russell DW

Title

Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.

Journal

J Biol Chem 266:7774-8 (1991)

Sequence

[hsa:1593]

LinkDB

DBGET integrated database retrieval system