KEGG ORTHOLOGY: K00659

ORTHOLOGY: K00659

Entry

K00659                      KO

Symbol

BAAT

Name

bile acid-CoA:amino acid N-acyltransferase [EC:2.3.1.65 3.1.2.2]

Pathway

map00120

Primary bile acid biosynthesis

map00430

Taurine and hypotaurine metabolism

map01040

Biosynthesis of unsaturated fatty acids

map01100

Metabolic pathways

map04146

Peroxisome

map04976

Bile secretion

Module

M00106

Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate

Reaction

R03718

choloyl-CoA:glycine N-choloyltransferase

R03720

choloyl-CoA:glycine N-choloyltransferase

R08744

3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:glycine N-choloyltransferase

R08745

3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

Disease

H01935

Familial hypercholanemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
   01040 Biosynthesis of unsaturated fatty acids
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.65  bile acid-CoA:amino acid N-acyltransferase
     K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase

Other DBs

GO:	0047963 0016290

Genes

HSA:

570(BAAT)

PTR:	472996 472997(BAAT)

PPS:	100992429(BAAT)

GGO:	101140183(BAAT)

PON:	100431907(BAAT) 100461881

PPYG:

129044183(BAAT) 129044494

NLE:	100598200(BAAT)

HMH:	116475340(BAAT)

SSYN:

129479097(BAAT)

MCC:	100429419(BAAT)

MCF:	102132073(BAAT)

MTHB:

126937773

MNI:	105480981(BAAT)

CSAB:

103219118(BAAT)

CATY:

105593023(BAAT)

PANU:

101007875(BAAT)

TGE:	112608227(BAAT)

MLEU:

105546769(BAAT) 105546778

RRO:	104670797(BAAT)

RBB:	108537176(BAAT)

TFN:	117098906(BAAT)

PTEH:

111536312(BAAT)

CANG:

105518150(BAAT)

CJC:	100394190 100396712(BAAT)

SBQ:

101036806

CIMI:

108303855(BAAT)

ANAN:

105727317 105727329

CSYR:

103256776 103256777

MMUR:

105873759(BAAT) 105873760

LCAT:

123645821(BAAT)

PCOQ:

105805378(BAAT) 105805407

OGA:	100957082 100957390

MMU:	12012(Baat) 209186(Acnat2) 230161(Acnat1)

MCAL:

110292343 110293184

MPAH:

110323775(Baat) 110323900

RNO:	29725(Baat) 313220(Acnat2) 681043(Acnat1)

MCOC:

116095310(Baat) 116096003

ANU:	117708778 117709136 117709479 117709552

MUN:	110557337 110557338

CGE:	100756252(Baat) 100756541

MAUA:

101835789 101836051

PROB:

127224676 127224678

PLEU:

114702315(Baat) 114702326

MORG:

121451765 121452021

MFOT:

126509815 126509848

AAMP:

119826151 119826854

NGI:	103749095 103749096 103749097

HGL:	101716142(Baat) 101717293

CPOC:

100719696(Baat) 100719973

CCAN:

109696243(Baat)

DORD:

105990724

DSP:	122122419(Baat) 122123761

PLOP:

125346048 125356113

NCAR:

124964800 124964957

MMMA:

107147751(Baat) 107147755

OCU:	100348617 100350133 100350872

OPI:	101519913(BAAT)

TUP:	102472797 102473647(BAAT)

GVR:

103607004

CFA:	481634 481635(BAAT)

CLUD:

112649971(BAAT) 112649972

VVP:	112930766(BAAT) 112930863

VLG:	121494953 121494954

NPO:	129494523 129494875

AML:	100476252 100476755

UMR:	103678524 103678630(BAAT)

UAH:	113260385 113260386

UAR:	123781224 123781225

ELK:	111145724 111145726

LLV:	125082990 125083316

MPUF:

101671389 101671902(BAAT)

MNP:	132024553 132024555

MLK:	131812402 131812403

NVS:	122917401 122917402

ORO:	101365672 101365978

EJU:	114213433 114213445

ZCA:

113934001

MLX:	118018214(BAAT) 118018215

NSU:	110581717(BAAT) 110581808

LWW:	102729180 102729479

FCA:	101095691(BAAT) 101096116

PYU:	121034756(BAAT) 121034758

PCOO:

112850975 112860692(BAAT)

PBG:	122474312 122474485(BAAT)

PVIV:

125150632 125150645

LRUF:

124526231 124526233

PTG:	102969591(BAAT) 102969870

PPAD:

109270057 109270058

PUC:	125926097 125926223

AJU:	106972069 106972070

HHV:	120224623(BAAT) 120224624

BTA:	530653 786798

BOM:

102268462

BIU:	109563300(BAAT)

BBUB:

102403928 102405119

BBIS:

104992074

CHX:	102174570(BAAT)

OAS:	101106149 101106409(BAAT)

BTAX:

128052871

ODA:

120863959

CCAD:

122431993

SSC:	100515185 102158534 110255172

CFR:	102523415(BAAT)

CBAI:

105067405(BAAT)

CDK:	105086911(BAAT)

VPC:	102529299(BAAT)

BACU:

103006095 103017253(BAAT)

BMUS:

118896620 118897292(BAAT)

LVE:	103081315 103082496(BAAT)

OOR:	101284164 101284403

DLE:	111188015(BAAT)

PCAD:

102984994(BAAT)

PSIU:

116754977 116755602

NASI:

112392644(BAAT) 112392655

ECB:	100054567 100063137(BAAT)

EPZ:	103552469(BAAT) 103568036

EAI:	106831794 106831795

MYB:	102262596 102263115

MYD:	102764048 102764710

MMYO:

118667244 118667245

MLF:	102433860 102434162(BAAT)

MDT:	132212209 132212211

PKL:	118716241 118716242

EFUS:

103286385(BAAT)

MNA:	107546604(BAAT)

DRO:	112304453(BAAT)

SHON:

118979701(BAAT)

AJM:	119045945(BAAT)

PDIC:

114503289(BAAT)

PHAS:

123819950(BAAT)

MMF:	118629687(BAAT)

PPAM:

129079385(BAAT)

HAI:	109395040(BAAT)

RFQ:	117032410(BAAT)

PALE:

102892341(BAAT) 102897591

PGIG:

120597018

PVP:	105296259(BAAT) 105296291

RAY:	107499578 107499579

MJV:	108397381(BAAT)

TOD:	119232402(BAAT)

SARA:

101540428(BAAT)

SETR:

126003761 126003845(BAAT)

LAV:	100654296 100670223

TMU:

101357199

ETF:	101654639 101654956

DNM:	101418518 101419268 101447075

MDO:	100017693 100023136(BAAT)

GAS:	123230833(BAAT) 123230834 123254112

SHR:	100924464 100925244

AFZ:

127554786

PCW:	110219134(BAAT)

TVP:	118831131 118832375

OAA:	100084056(BAAT)

GGA:	769879(BAAT)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

125694885(BAAT)

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

103805502(BAAT)

SVG:

MMEA:

HRT:

SATI:

FPG:

FCH:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HLE:	104829793(BAAT)

AGEN:

126046987

GCL:

127017185

MNB:	103778534(BAAT)

DPUB:

104296264(BAAT)

EGZ:	104134405(BAAT)

NNI:	104008979(BAAT)

PCRI:

AFOR:

CLV:

CUCA:

TEO:

OHA:

ACAR:

CPEA:

CVF:	104283272(BAAT)

RTD:

128908803

AAM:

106494986

AROW:

112960829(BAAT)

NPD:

112952722

TGT:

104578818

DNE:

112988642

SCAM:

104151146(BAAT)

ASN:	102368085(BAAT) 102376159 102383708

AMJ:	102559248 102564970(BAAT) 102575228

CPOO:

109323479 109323497

GGN:	109297368 109297370

PSS:	102447700(BAAT) 102461463 102461871

CMY:	102939533(BAAT) 102947935

CCAY:

125636624(BAAT) 125638328

DCC:	119856403(BAAT) 119857880

CPIC:

101932563 101938826(BAAT)

TST:	117876003 117879669(BAAT)

CABI:

116825950(BAAT)

MRV:	120403019 120407254(BAAT) 120407813

ACS:	100566890(baat)

ASAO:

132772260(BAAT)

PVT:	110078385(BAAT)

SUND:

121930998

PBI:	103065567(BAAT)

PMUR:

107292645 107292672

CTIG:

120308320 120308321 120308323

TSR:	106538123(BAAT)

PGUT:

117667061(BAAT)

APRI:

131184117(BAAT)

PTEX:

113449132(BAAT)

NSS:	113421915(BAAT)

VKO:	123021162 123021248

PMUA:

114600844(BAAT)

PRAF:

128418018(BAAT)

ZVI:	118089420(BAAT)

HCG:	128341173 128341626(BAAT)

GJA:	107106123 107106126(BAAT)

STOW:

125427301 125436721(BAAT)

EMC:	129324679 129334736(BAAT)

XLA:	100137716(XB5872576.L) 108707337(baat.S) 121393106

XTR:	100125079(baat) 100488333 100496940 100497260 100497423 100497580 100497738 116408197

NPR:	108790690 108790705 108790706 108795509

RTEM:

120926637 120926656 120926672 120943647

BBUF:

120992241(BAAT) 121008572

BGAR:

122924848 122924849 122924850 122945314

MUO:	115482004(BAAT)

SRX:

SANH:

CCAR:

CAUA:

IPU:

IFU:

PHYP:

TFD:

TVC:

TRN:

CMAO:

CHAR:

TFS:

TNG:	GSTEN00014025G001 GSTEN00019694G001

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117256189 117256459 117256968

EFO:	125888830 125897968 125897977 125897983 125897996

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

SCHU:

CUD:

ALAT:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

NWH:

MCEP:

POV:	109628957 109644008

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

SDU:

SLAL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110161506 110171280 110171322

MALB:

BSPL:

SJO:

SASA:

STRU:

OGO:

ONE:

OKI:

OKE:

SNH:	120062369 120065229

CCLU:

ELS:

SFM:

AANG:

LCM:	102356569(BAAT) 102363365 102363627

CIN:	100175018 100182847 100184394

SCLV:

120325725 120329571 120329639 120337556 120343818 120343819 120344834 120347055 120348310

SPU:	100892177 115926355

APLC:

110981446 110989383 110991145

ARUN:

117295575 117296628 117297972 117299118

AJC:	117105456 117105473

HAME:

PCLA:

PTRU:

HAZT:

LGI:	LOTGIDRAFT_125734

PVUL:

126821684

PCAN:

112570277 112570289 112570596

HRF:	124137037 124146464

HRJ:	124268350 124270995 124270996 124270998 124276134 124277115 124277116

CRG:

105328098

CANU:

128163038 128175585

CVN:	111131209 111131381

OED:	125652746 125652747

MYI:

110465077

PMAX:

117323580 117335375 117335376 117336519

MMER:

123550893 123552208

RPHI:

132733646 132733647 132737676

DPOL:

127853306 127853745 127870784 127873764

MAEA:

128209818 128225590

OBI:

106881808

OSN:	115226141 115226175 115232312 115232313

LJP:

135480621

LAK:

106169569

NVE:

5519541

EPA:	110233238 110233246 110242348

ADF:

107346883

AMIL:

114966874

PDAM:

113665012 113665467 113666427

SPIS:

111328316 111331670 111339322 111339330 111339338 111341936

HSY:	130624222 130648508 130662424

RES:	135680732 135680733 135684962 135696659 135696660 135696661 135696663 135696664 135696665 135696678 135696824

» show all

Reference

PMID:8034703

Authors

Falany CN, Johnson MR, Barnes S, Diasio RB

Title

Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.

Journal

J Biol Chem 269:19375-9 (1994)

Sequence

[hsa:570]

Reference

PMID:12543708

Authors

Russell DW

Title

The enzymes, regulation, and genetics of bile acid synthesis.

Journal

Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712

LinkDB

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