KEGG   ORTHOLOGY: K00659
Entry
K00659                      KO                                     
Symbol
BAAT
Name
bile acid-CoA:amino acid N-acyltransferase [EC:2.3.1.65 3.1.2.2]
Pathway
map00120  Primary bile acid biosynthesis
map00430  Taurine and hypotaurine metabolism
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map04146  Peroxisome
map04976  Bile secretion
Module
M00106  Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate
Disease
H01935  Familial hypercholanemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
   01040 Biosynthesis of unsaturated fatty acids
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.65  bile acid-CoA:amino acid N-acyltransferase
     K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
Other DBs
RN: R03718 R03720 R08744 R08745
GO: 0047963 0016290
Genes
HSA: 570(BAAT)
PTR: 472997
PPS: 100992429(BAAT)
GGO: 101140183(BAAT)
PON: 100431907(BAAT) 100461881
NLE: 100598200(BAAT)
MCC: 100429419(BAAT)
MCF: 102132073(BAAT)
CSAB: 103219118(BAAT)
CATY: 105593023(BAAT)
PANU: 101007875(BAAT)
TGE: 112608227(BAAT)
RRO: 104670797(BAAT)
RBB: 108537176(BAAT)
TFN: 117098906(BAAT)
PTEH: 111536312(BAAT)
CJC: 100394190 100396712(BAAT)
SBQ: 101036806
MMUR: 105873759(BAAT) 105873760
MMU: 12012(Baat) 209186(Acnat2) 230161(Acnat1)
MPAH: 110323775(Baat) 110323900
RNO: 29725(Baat) 313220(Acnat2) 681043(Acnat1)
MCOC: 116095310(Baat) 116096003
MUN: 110557337 110557338(Baat)
CGE: 100756252(Baat) 100756541
PLEU: 114702315(Baat) 114702326
HGL: 101716142(Baat) 101717293
CPOC: 100719696(Baat) 100719973
CCAN: 109696243(Baat)
DORD: 105990724
DSP: 122122419(Baat) 122123761
OPI: 101519913(BAAT)
TUP: 102472797 102473647(BAAT)
CFA: 481635(BAAT)
VVP: 112930766(BAAT) 112930863
UAH: 113260385 113260386(BAAT)
MPUF: 101671389 101671902(BAAT)
ZCA: 113934001
MLX: 118018214(BAAT) 118018215
FCA: 101095691(BAAT) 101096116
PYU: 121034756(BAAT) 121034758
PBG: 122474312 122474485(BAAT)
PTG: 102969591(BAAT) 102969870
HHV: 120224623(BAAT) 120224624
BTA: 530653 786798(BAAT)
BOM: 102268462
BIU: 109563300(BAAT)
CHX: 102174570(BAAT)
ODA: 120863959
CCAD: 122431993
CFR: 102523415(BAAT)
CBAI: 105067405(BAAT)
CDK: 105086911(BAAT)
VPC: 102529299(BAAT)
BACU: 103006095 103017253(BAAT)
LVE: 103081315 103082496(BAAT)
OOR: 101284164(BAAT) 101284403
DLE: 111188015(BAAT)
PCAD: 102984994(BAAT)
ECB: 100054567 100063137(BAAT)
EPZ: 103552469(BAAT) 103568036
MLF: 102433860 102434162(BAAT)
MNA: 107546604(BAAT)
HAI: 109395040(BAAT)
DRO: 112304453(BAAT)
SHON: 118979701(BAAT)
AJM: 119045945(BAAT)
PDIC: 114503289(BAAT)
PHAS: 123819950(BAAT)
MMF: 118629687(BAAT)
RFQ: 117032410(BAAT)
PALE: 102892341(BAAT) 102897591
PGIG: 120597018
PVP: 105296259(BAAT) 105296291
MJV: 108397381(BAAT)
TOD: 119232402(BAAT)
SARA: 101540428(BAAT)
TMU: 101357199
MDO: 100023136(BAAT)
PCW: 110219134(BAAT)
OAA: 100084056(BAAT)
GGA: 769879(BAAT)
PCOC: 116242919
MGP: 100539658
CJO: 107314177
NMEL: 110400838
APLA: 101797844
ACYG: 106048282
AFUL: 116490259
TGU: 115495423
LSR: 110485078
SCAN: 103822142
PMOA: 120499625
OTC: 121339708
PRUF: 121355202
GFR: 102037789
FAB: 101815920
PHI: 102101793
PMAJ: 107206148
CCAE: 111930612
ETL: 114063343
ZAB: 102062391
FPG: 101924136
FCH: 102059453
CLV: 102094683
EGZ: 104134405(BAAT)
NNI: 104008979(BAAT)
ACUN: 113481099
TALA: 116961616
ACHC: 115352108
AAM: 106494986
AROW: 112960829(BAAT)
NPD: 112952722
DNE: 112988642
CMY: 102939533(BAAT) 102947935
CPIC: 101932563 101938826(BAAT)
TST: 117876003 117879669(BAAT)
CABI: 116825950(BAAT)
ACS: 100566890(baat)
PVT: 110078385(BAAT)
SUND: 121930998
PBI: 103065567(BAAT)
TSR: 106538123(BAAT)
PGUT: 117667061(BAAT)
PMUA: 114600844(BAAT)
ZVI: 118089420(BAAT)
GJA: 107106123 107106126(BAAT)
XLA: 100137716(XB5872576.L) 108707337(baat.S)
BBUF: 120992241(BAAT) 121008572
SRX: 107726829
CCAR: 109068937
IPU: 108280978
PHYP: 113532413
EEE: 113584003
CGOB: 115008157
SLUC: 116066678
ECRA: 117944007
PFLV: 114553794
GAT: 120835251
PPUG: 119193948
CUD: 121506802
ONL: 109198392
OAU: 116329896
OLA: 101166298
OML: 112145720
XMA: 102226402
XCO: 114135870
XHE: 116711136
PRET: 103465285
PFOR: 103144302
PLAI: 106934498
PMEI: 106906822
GAF: 122834742
CVG: 107083302
CTUL: 119791826
GMU: 124856113
NFU: 107385610
KMR: 108235667
NWH: 119411976
HHIP: 117761208
SDU: 111221490
SLAL: 111667779
HCQ: 109522368
MALB: 109956248
OGO: 124003938
ONE: 115143032
ELS: 105010081
SFM: 108933858
AANG: 118211819
HAME: 121871783
PCLA: 123754342
PTRU: 123506716
HAZT: 108682704
CRG: 105328098
MYI: 110465077
OBI: 106881808
LAK: 106169569
NVE: 5519541
ADF: 107346883
AMIL: 114966874
 » show all
Reference
PMID:8034703
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J Biol Chem 269:19375-9 (1994)
  Sequence
[hsa:570]
Reference
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
LinkDB

KEGG   ENZYME: 2.3.1.65
Entry
EC 2.3.1.65                 Enzyme                                 
Name
bile acid-CoA:amino acid N-acyltransferase;
glycine---taurine N-acyltransferase;
amino acid N-choloyltransferase;
BAT;
glycine N-choloyltransferase;
BACAT;
cholyl-CoA glycine-taurine N-acyltransferase;
cholyl-CoA:taurine N-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
choloyl-CoA:glycine N-choloyltransferase
Reaction(IUBMB)
choloyl-CoA + glycine = CoA + glycocholate [RN:R03718]
Reaction(KEGG)
R03718;
(other) R03720 R08744 R08745
Substrate
choloyl-CoA [CPD:C01794];
glycine [CPD:C00037]
Product
CoA [CPD:C00010];
glycocholate [CPD:C01921]
Comment
Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly [4]. The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase [7]. Bile-acid---amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol [4]. This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate---CoA ligase.
History
EC 2.3.1.65 created 1983, modified 2005
Pathway
ec00120  Primary bile acid biosynthesis
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K00659  bile acid-CoA:amino acid N-acyltransferase
Genes
HSA570(BAAT)
PTR472997
PPS100992429(BAAT)
GGO101140183(BAAT)
PON100431907(BAAT) 100461881
NLE100598200(BAAT)
MCC100429419(BAAT)
MCF102132073(BAAT)
CSAB103219118(BAAT)
CATY105593023(BAAT)
PANU101007875(BAAT)
TGE112608227(BAAT)
RRO104670797(BAAT)
RBB108537176(BAAT)
TFN117098906(BAAT)
PTEH111536312(BAAT)
CJC100394190 100396712(BAAT)
SBQ101036806
CSYR103256776 103256777
MMUR105873759(BAAT) 105873760
OGA100957082 100957390
MMU12012(Baat) 209186(Acnat2) 230161(Acnat1)
MCAL110292343 110293184
MPAH110323775(Baat) 110323900
RNO29725(Baat) 313220(Acnat2) 681043(Acnat1)
MCOC116095310(Baat) 116096003
MUN110557337 110557338(Baat)
CGE100756252(Baat) 100756541
PLEU114702315(Baat) 114702326
NGI103749095 103749096 103749097
HGL101716142(Baat) 101717293
CPOC100719696(Baat) 100719973
CCAN109696243(Baat)
DORD105990724
DSP122122419(Baat) 122123761
OCU100348617 100350133 100350872
OPI101519913(BAAT)
TUP102472797 102473647(BAAT)
CFA481635(BAAT)
VVP112930766(BAAT) 112930863
VLG121494953 121494954
AML100476252 100476755
UMR103678524 103678630
UAH113260385 113260386(BAAT)
UAR123781224 123781225
ELK111145724 111145726
LLV125082990 125083316
MPUF101671389 101671902(BAAT)
ORO101365672 101365978
EJU114213433 114213445
ZCA113934001
MLX118018214(BAAT) 118018215
FCA101095691(BAAT) 101096116
PYU121034756(BAAT) 121034758
PBG122474312 122474485(BAAT)
PTG102969591(BAAT) 102969870
PPAD109270057 109270058
AJU106972069 106972070
HHV120224623(BAAT) 120224624
BTA530653 786798(BAAT)
BOM102268462
BIU109563300(BAAT)
BBUB102403928 102405119
CHX102174570(BAAT)
OAS101106149 101106409
ODA120863959
CCAD122431993
SSC100515185 102158534 110255172
CFR102523415(BAAT)
CBAI105067405(BAAT)
CDK105086911(BAAT)
VPC102529299(BAAT)
BACU103006095 103017253(BAAT)
LVE103081315 103082496(BAAT)
OOR101284164(BAAT) 101284403
DLE111188015(BAAT)
PCAD102984994(BAAT)
PSIU116754977 116755602
ECB100054567 100063137(BAAT)
EPZ103552469(BAAT) 103568036
EAI106831794 106831795
MYB102262596 102263115
MYD102764048 102764710
MMYO118667244 118667245
MLF102433860 102434162(BAAT)
MNA107546604(BAAT)
PKL118716241 118716242
HAI109395040(BAAT)
DRO112304453(BAAT)
SHON118979701(BAAT)
AJM119045945(BAAT)
PDIC114503289(BAAT)
PHAS123819950(BAAT)
MMF118629687(BAAT)
RFQ117032410(BAAT)
PALE102892341(BAAT) 102897591
PGIG120597018
PVP105296259(BAAT) 105296291
RAY107499578 107499579
MJV108397381(BAAT)
TOD119232402(BAAT)
SARA101540428(BAAT)
LAV100654296 100670223
TMU101357199
DNM101418518 101419268 101447075
MDO100023136(BAAT)
GAS123230833(BAAT) 123230834 123254112
SHR100924464 100925244
PCW110219134(BAAT)
OAA100084056(BAAT)
GGA769879(BAAT)
PCOC116242919
MGP100539658
CJO107314177
NMEL110400838
APLA101797844
ACYG106048282
AFUL116490259
TGU115495423
LSR110485078
SCAN103822142
PMOA120499625
OTC121339708
PRUF121355202
GFR102037789
FAB101815920
PHI102101793
PMAJ107206148
CCAE111930612
ETL114063343
ZAB102062391
FPG101924136
FCH102059453
CLV102094683
EGZ104134405(BAAT)
NNI104008979(BAAT)
ACUN113481099
TALA116961616
ACHC115352108
AAM106494986
AROW112960829(BAAT)
NPD112952722
DNE112988642
ASN102368085(BAAT) 102376159 102383708
AMJ102559248 102564970(BAAT) 102575228
CPOO109323479 109323497
GGN109297368 109297370
PSS102447700(BAAT) 102461463 102461871
CMY102939533(BAAT) 102947935
CPIC101932563 101938826(BAAT)
TST117876003 117879669(BAAT)
CABI116825950(BAAT)
MRV120403019 120407254(BAAT) 120407813
ACS100566890(baat)
PVT110078385(BAAT)
SUND121930998
PBI103065567(BAAT)
PMUR107292645 107292672
TSR106538123(BAAT)
PGUT117667061(BAAT)
VKO123021162 123021248
PMUA114600844(BAAT)
ZVI118089420(BAAT)
GJA107106123 107106126(BAAT)
XLA100137716(XB5872576.L) 108707337(baat.S)
XTR100125079(baat) 100488333 100496940 100497260 100497423 100497580 100497738 116408197
NPR108790690 108790705 108790706 108795509
RTEM120926637 120926656 120926672 120943647
BBUF120992241(BAAT) 121008572
BGAR122924848 122924849 122924850 122945314
SRX107726829
SANH107689220 107689257
CCAR109068937
CAUA113061125 113068447
IPU108280978
PHYP113532413
EEE113584003
TNGGSTEN00014025G001 GSTEN00019694G001
CGOB115008157
ELY117256189 117256459 117256968
PLEP121953471 121953523
SLUC116066678
ECRA117944007
PFLV114553794
GAT120835251
PPUG119193948
CUD121506802
ONL109198392
OAU116329896
OLA101166298
OML112145720
XMA102226402
XCO114135870
XHE116711136
PRET103465285
PFOR103144302
PLAI106934498
PMEI106906822
GAF122834742
CVG107083302
CTUL119791826
GMU124856113
NFU107385610
KMR108235667
NWH119411976
POV109628957 109644008
SSEN122767935 122768787
HHIP117761208
SDU111221490
SLAL111667779
HCQ109522368
BPEC110161506 110171280 110171322
MALB109956248
SASA106584567 106609489
OGO124003938
ONE115143032
SNH120062369 120065229
ELS105010081
SFM108933858
AANG118211819
LCM102356569(BAAT) 102363365 102363627
CIN100175018 100182847 100184394
SCLV120325725 120329571 120329639 120337556 120343818 120343819 120344834 120347055 120348310
SPU100892177 115926355
APLC110981446 110989383 110991145
HAME121871783
PCLA123754342
PTRU123506716
HAZT108682704
LGILOTGIDRAFT_125734
PCAN112570277 112570289 112570596
HRF124137037 124146464
HRJ124268349 124268350 124270995 124270996 124270998 124276134 124277115 124277116
CRG105328098
MYI110465077
PMAX117323580 117335375 117335376 117336519
MMER123545107 123545108 123550893 123552208
OBI106881808
OSN115226141 115226175 115232312 115232313
LAK106169569
NVE5519541
EPA110233238 110233246 110242348
ADF107346883
AMIL114966874
PDAM113665012 113665467 113666427
SPIS111328316 111331670 111339322 111339330 111339338 111341936
 » show all
Reference
1  [PMID:7372637]
  Authors
Czuba B, Vessey DA.
  Title
Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver.
  Journal
J Biol Chem 255:5296-9 (1980)
Reference
2
  Authors
Jordan, T.W., Lee, R. and Lim, W.C.
  Title
Isoelectric focussing of soluble and particulate benzoyl-CoA and cholyl-CoA:amino acid N-acyltransferases from rat liver.
  Journal
Biochem Int 1:325-330 (1980)
Reference
3  [PMID:422567]
  Authors
Vessey DA.
  Title
The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N-acyltransferase activities from bovine liver.
  Journal
J Biol Chem 254:2059-63 (1979)
Reference
4  [PMID:2037576]
  Authors
Johnson MR, Barnes S, Kwakye JB, Diasio RB.
  Title
Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.
  Journal
J Biol Chem 266:10227-33 (1991)
  Sequence
[hsa:570]
Reference
5  [PMID:12454267]
  Authors
Falany CN, Xie X, Wheeler JB, Wang J, Smith M, He D, Barnes S.
  Title
Molecular cloning and expression of rat liver bile acid CoA ligase.
  Journal
J Lipid Res 43:2062-71 (2002)
DOI:10.1194/jlr.m200260-jlr200
Reference
6  [PMID:12951368]
  Authors
He D, Barnes S, Falany CN.
  Title
Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization.
  Journal
J Lipid Res 44:2242-9 (2003)
DOI:10.1194/jlr.M300128-JLR200
  Sequence
[rno:29725]
Reference
7  [PMID:12810727]
  Authors
O'Byrne J, Hunt MC, Rai DK, Saeki M, Alexson SE.
  Title
The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.
  Journal
J Biol Chem 278:34237-44 (2003)
DOI:10.1074/jbc.M300987200
  Sequence
[hsa:570]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.65
IUBMB Enzyme Nomenclature: 2.3.1.65
ExPASy - ENZYME nomenclature database: 2.3.1.65
BRENDA, the Enzyme Database: 2.3.1.65
CAS: 65979-40-0
LinkDB

KEGG   REACTION: R03720
Entry
R03720                      Reaction                               
Name
Choloyl-CoA:glycine N-choloyltransferase
Definition
Choloyl-CoA + Taurine <=> CoA + Taurocholate
Equation
Reaction class
RC00004  C00010_C01794
RC00096  C00245_C05122
Enzyme
Pathway
rn00120  Primary bile acid biosynthesis
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Module
M00106  Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate
Orthology
K00659  bile acid-CoA:amino acid N-acyltransferase [EC:2.3.1.65 3.1.2.2]
LinkDB

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