KEGG   ORTHOLOGY: K01003
Entry
K01003                      KO                                     
Symbol
bcpA
Name
oxaloacetate decarboxylase [EC:4.1.1.112]
Pathway
map00620  Pyruvate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K01003  bcpA; oxaloacetate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.112  oxaloacetate decarboxylase
     K01003  bcpA; oxaloacetate decarboxylase
Other DBs
RN: R00217
COG: COG2513
GO: 0008948
Genes
PAE: PA4872
PAEV: N297_5042
PAEI: N296_5042
PAU: PA14_64440(bcpA)
PAP: PSPA7_5594
PAG: PLES_52581
PAF: PAM18_4984
PNC: NCGM2_0654(bcpA)
PAEB: NCGM1900_5613(bcpA)
PDK: PADK2_25850
PAEP: PA1S_26460
PAEM: U769_26725
PAEL: T223_26920
PAEG: AI22_07535
PAEC: M802_5040
PAEO: M801_4907
PMY: Pmen_0689
PMK: MDS_0774
PPSE: BN5_0574
PPU: PP_1389
PPF: Pput_4334
PPT: PPS_4264
PPI: YSA_02878
PPUH: B479_21440
PPUT: L483_26510
PPUN: PP4_09380
PPUD: DW66_4652
PMON: X969_20985
PMOT: X970_20620
PSB: Psyr_1256
PSYR: N018_19415
PSP: PSPPH_1328(bcpA)
PFL: PFL_2455
PPRO: PPC_2494
PFS: PFLU_3105
PFB: VO64_0355
PMAN: OU5_5864
PEN: PSEEN4356
PSA: PST_3733(bcpA)
PSZ: PSTAB_3695(bcpA)
PSR: PSTAA_3825(bcpA)
PSTT: CH92_18585
PKC: PKB_5190
PSES: PSCI_0548
PSEM: TO66_12015
PSOS: POS17_2450
PANR: A7J50_2850
PSIL: PMA3_17455
PALL: UYA_03295
PDW: BV82_0637
PSEP: C4K39_2367
CSA: Csal_0251
EME: CEM_228
BXE: Bxe_B2147
BXB: DR64_4476
BJA: bll5266(bll5266)
BRA: BRADO3250
BBT: BBta_4901
BRS: S23_30220
AOL: S58_31240
BRAD: BF49_6364
BRO: BRAD285_3147(OAD)
BARH: WN72_29400
RPA: RPA3174
RPB: RPB_2368
RPC: RPC_3351
RPD: RPD_3092
RPE: RPE_3438
RPT: Rpal_3584
TSO: IZ6_12760
SECH: B18_11500
SHUM: STHU_15720
STEL: STAQ_11820
 » show all
Reference
  Authors
Narayanan BC, Niu W, Han Y, Zou J, Mariano PS, Dunaway-Mariano D, Herzberg O
  Title
Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily.
  Journal
Biochemistry 47:167-82 (2008)
DOI:10.1021/bi701954p
  Sequence
[pae:PA4872]
LinkDB

KEGG   ENZYME: 4.1.1.112
Entry
EC 4.1.1.112                Enzyme                                 
Name
oxaloacetate decarboxylase;
oxaloacetate beta-decarboxylase;
oxalacetic acid decarboxylase;
oxalate beta-decarboxylase;
oxaloacetate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
oxaloacetate carboxy-lyase (pyruvate-forming)
Reaction(IUBMB)
oxaloacetate = pyruvate + CO2 [RN:R00217]
Reaction(KEGG)
R00217;
(other) R00995
Substrate
oxaloacetate [CPD:C00036]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011]
Comment
Requires a divalent metal cation. The enzymes from the fish Gadus morhua (Atlantic cod) and the bacterium Micrococcus luteus prefer Mn2+, while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg2+. Unlike EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)], there is no evidence of the enzyme's involvement in Na+ transport.
History
EC 4.1.1.112 created 1961 as EC 4.1.1.3, modified 1986, modified 2000, part transferred 2018 to EC 4.1.1.112
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K01003  oxaloacetate decarboxylase
Genes
PAEPA4872
PAEVN297_5042
PAEIN296_5042
PAUPA14_64440(bcpA)
PAPPSPA7_5594
PAGPLES_52581
PAFPAM18_4984
PNCNCGM2_0654(bcpA)
PAEBNCGM1900_5613(bcpA)
PDKPADK2_25850
PSGG655_25700
PRPM062_25710
PAEPPA1S_26460
PAERPA1R_gp2794
PAEMU769_26725
PAELT223_26920
PAESSCV20265_5532
PAEUBN889_05423
PAEGAI22_07535
PAECM802_5040
PAEOM801_4907
PMYPmen_0689
PMKMDS_0774
PREPCA10_51200
PPSEBN5_0574
PFUWKF707C_51420
PALCA0T30_06335
PCQPcP3B5_56180
PMUIG4G71_06270
PPUPP_1389
PPFPput_4334
PPGPputGB1_4424
PPWPputW619_1029 PputW619_5152
PPTPPS_4264
PPBPPUBIRD1_4171
PPIYSA_02878
PPXT1E_0246 T1E_1251
PPUHB479_21440
PPUTL483_26510
PPUNPP4_09380
PPUDDW66_4652
PFVPsefu_4085
PMONX969_20985
PMOTX970_20620
PMOSO165_000295
PPJRK21_00264
PORAPT59_20885
PMOLCLJ08_07525
PSTPSPTO_1443
PSBPsyr_1256
PSYRN018_19415
PSPPSPPH_1328(bcpA)
PSAVPSA3335_10410
PAMGBKM19_009200
PCIPCH70_11520
PAVLBKM03_08075
PVDCFBP1590__4140
PCABJGS08_18535
PFLPFL_2455
PPRCPFLCHA0_c25150
PPROPPC_2494
PFEPSF113_3877
PFOPfl01_2052 Pfl01_2772
PFSPFLU_3105
PFCPflA506_2644
PPZH045_06690
PFBVO64_0355
PMANOU5_5864
PTVAA957_00130
PCGAXG94_25285
PVRPverR02_15105
PAZOAYR47_22365
POIBOP93_12215
PRXHRH33_13955
PFWPF1751_v1c26670
PFFPFLUOLIPICF723000
PFXA7318_13420
PENPSEEN4356
PSAPST_3733(bcpA)
PSZPSTAB_3695(bcpA)
PSRPSTAA_3825(bcpA)
PSCA458_02800
PSJPSJM300_07670 PSJM300_17035
PSHPsest_0551
PSTUUIB01_02505
PSTTCH92_18585
PCHLLLJ08_02675
PBMCL52_17970
PLULFOB45_09370
PBAPSEBR_a1851
PBCCD58_20180
PPUUPputUW4_03216
PDRH681_21810
PSVPVLB_04965
PSKU771_12260
PKCPKB_5190
PCHEY04_11210
PCZPCL1606_37440
PCPJM49_18735
PFZAV641_11725
PALKPSAKL28_40210
PRHLT40_20090
PSWLK03_01240
PPVNJ69_13060
PSESPSCI_0548
PSEMTO66_12015
PSECCCOS191_4259
PPSYAOC04_08840
PSOSPOS17_2450
PKRAYO71_13380
PFKPFAS1_22385
PANRA7J50_2850
PPSLBJP27_15590
PSETTHL1_3205 THL1_5159
PSILPMA3_17455
PYMAK972_2128
PSEDDM292_00575
PKEDLD99_10910
PALLUYA_03295
PUMHGP31_12610
POJPtoMrB4_50070
PGGFX982_04278
PPSHG5J76_14920
PGYAWU82_18565
PLALFXN65_25080
PSEJHNQ25_20885
PVKEPZ47_10060
PEZHWQ56_12770
PBZGN234_07975
PKHJLK41_03530
PTYJWV26_14290
PMAOPMYSY11_4000
PATAJWU58_16845
PDWBV82_0637
PZEHU754_018685
PMOEHV782_011605
PCAMHNE05_01855
PSEPC4K39_2367
PVWHU752_022620
PTRTHU722_0014560
PXAKSS93_08595
PSAMHU731_001710
PTZHU718_011810
PQIKH389_07390
PXNHU772_005160
PHVHU739_002595 HU739_007225
PPRGHU725_004745
PANHHU763_019625
PASGKSS96_15025
PFAKKSS94_05355
PMUYKSS95_08190
PMAMKSS90_20675
PAZEKSS91_10870
PALVKSS97_10730
PORYEJA05_05395
PWZJ7655_03415
PTKEXN22_08005
PTWTUM18999_54370
PZAHU749_011075
PIEHU724_011255
PWYHU734_006185
AVNAvin_20130
AVLAvCA_20130
AVDAvCA6_20130
ACXAchr_24790
HPEGEAO82_13660
CSACsal_0251
EMECEM_228
HAAA5892_05580
KUSB9G99_04730
KMAB9H00_10430
KUYFY550_15420
MMWMmwyl1_2926
MMEMarme_2883
MPCMar181_1138
MPRIMP3633_1287
MARDIBG28_07245
MFOIJSY38_02020
MPRFJ8N69_12985
MARSA8C75_13560
BXEBxe_B2147
BXBDR64_4476
PDIOPDMSB3_0965.1
BBROBAU06_03205
BOZDBV39_02745
BJAbll5266(bll5266)
BJUBJ6T_45150
BJPRN69_21910
BRABRADO3250
BBTBBta_4901
BRSS23_30220
AOLS58_31240
BRCBCCGELA001_22110
BRADBF49_6364
BICLMTR13_17365
BROBRAD285_3147(OAD)
BRKCWS35_21195
BOTCIT37_28005
BRQCIT40_18365
BGQX265_22215
BGZXH91_15160
BSYMCIT39_17655
BBETF8237_29990
BARHWN72_29400
BVZBRAD3257_3821
BELBE61_49010
BDGLPJ38_27985
BSEPHAP48_0043225
BQBJ4P68_0002615
RPARPA3174
RPBRPB_2368
RPCRPC_3351
RPDRPD_3092
RPERPE_3438
RPTRpal_3584
RPXRpdx1_2253
RBKE0H22_11460
TRBHB776_05445
STARG3545_12755
RHZRHPLAN_70690
TSOIZ6_12760
SECHB18_11500
RMTIAI58_06050
SHUMSTHU_15720
SVCSTVA_37320
STELSTAQ_11820
PARHI5S86_06185
 » show all
Reference
1  [PMID:5972993]
  Authors
Schmitt A, Bottke I, Siebert G.
  Title
[Properties of oxaloacetate decarboxylase from codfish muscles]
  Journal
Hoppe Seylers Z Physiol Chem 347:18-34 (1966)
Reference
2
  Authors
Herbert, D.
  Title
Oxalacetic carboxylase of Micrococcus lysodeikticus.
  Journal
Methods Enzymol 1:753-757 (1955)
Reference
3  [PMID:14205502]
  Authors
HORTON AA, KORNBERG HL.
  Title
OXALOACETATE 4-CARBOXY-LYASE FROM PSEUDOMONAS OVALIS CHESTER.
  Journal
Biochim Biophys Acta 89:381-3 (1964)
DOI:10.1016/0926-6569(64)90236-6
Reference
4  [PMID:15251467]
  Authors
Sender PD, Martin MG, Peiru S, Magni C
  Title
Characterization of an oxaloacetate decarboxylase that belongs to the malic enzyme family.
  Journal
FEBS Lett 570:217-22 (2004)
DOI:10.1016/j.febslet.2004.06.038
Reference
5  [PMID:18081320]
  Authors
Narayanan BC, Niu W, Han Y, Zou J, Mariano PS, Dunaway-Mariano D, Herzberg O
  Title
Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily.
  Journal
Biochemistry 47:167-82 (2008)
DOI:10.1021/bi701954p
  Sequence
[pae:PA4872]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.112
IUBMB Enzyme Nomenclature: 4.1.1.112
ExPASy - ENZYME nomenclature database: 4.1.1.112
BRENDA, the Enzyme Database: 4.1.1.112
CAS: 9024-98-0
LinkDB

KEGG   REACTION: R00217
Entry
R00217                      Reaction                               
Name
oxaloacetate carboxy-lyase (pyruvate-forming)
Definition
Oxaloacetate <=> Pyruvate + CO2
Equation
Reaction class
RC00040  C00022_C00036
Enzyme
1.1.1.38        1.1.1.40        4.1.1.112
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
Orthology
K01003  oxaloacetate decarboxylase [EC:4.1.1.112]
Other DBs
RHEA: 15644
LinkDB

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