KEGG   ORTHOLOGY: K01655
Entry
K01655                      KO                                     
Symbol
LYS21, LYS20
Name
homocitrate synthase [EC:2.3.3.14]
Pathway
map00300  Lysine biosynthesis
map00620  Pyruvate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Reaction
R00271  acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K01655  LYS21, LYS20; homocitrate synthase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K01655  LYS21, LYS20; homocitrate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14  homocitrate synthase
     K01655  LYS21, LYS20; homocitrate synthase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K01655
Other DBs
COG: COG0119
GO: 0004410
Genes
SCE: YDL131W(LYS21) YDL182W(LYS20)
SEUB: DI49_0897
SPAO: SPAR_D00610 SPAR_D01060
AGO: AGOS_ADR107W
ERC: Ecym_8045
KLA: KLLA0_E23695g KLLA0_F05489g
KMX: KLMA_10771(LYS21) KLMA_60493(LYS21)
LTH: KLTH0E12848g KLTH0H02486g
VPO: Kpol_2000p11
ZRO: ZYRO0A13222g ZYRO0C09416g
CGR: 2889536(GVI51_J06259) 2889949(LYS21)
NCS: NCAS_0A13800(NCAS0A13800) NCAS_0E03640(NCAS0E03640)
NDI: NDAI_0A02240(NDAI0A02240) NDAI_0A02990(NDAI0A02990)
TPF: TPHA_0P00840(TPHA0P00840)
TBL: TBLA_0A05940(TBLA0A05940)
TGB: HG536_0C05440 HG536_0H02920
TDL: TDEL_0B02910(TDEL0B02910) TDEL_0H01490(TDEL0H01490)
KAF: KAFR_0B01160(KAFR0B01160)
KNG: KNAG_0B02880(KNAG0B02880) KNAG_0C04080(KNAG0C04080)
ZMK: HG535_0A05750 HG535_0G01540
SLUD: SCDLUD_000290 SCDLUD_002024
DHA: DEHA2D13222g DEHA2F08514g
PIC: PICST_28701(LYS21) PICST_89386(LYS22)
PGU: PGUG_01126 PGUG_01480
SPAA: SPAPADRAFT_136285(LYS22) SPAPADRAFT_58182
LEL: PVL30_001014(LYS1_1) PVL30_001780(LYS21)
LBG: 92207809(LODBEIA_P26130) 92209571(LODBEIA_P43750)
CAL: CAALFM_C104730CA(LYS21) CAALFM_C204460WA(LYS22)
CTP: CTRG_01594 CTRG_04686
COT: CORT_0A12020 CORT_0B06650
CDU: CD36_04470 CD36_19070
CTEN: 18246775(LYS22) 18248055(LYS21)
CLU: CLUG_01219 CLUG_05100
CLUS: A9F13_03g01375 A9F13_06g00154
CAUR: CJI96_0001452 CJI96_0002255
ASAU: 88171985(PUMCH_000917) 88175465(PUMCH_004405)
PPA: PAS_chr1-1_0313 PAS_chr1-4_0421
PKZ: C5L36_0C01170 C5L36_0D05690
BNN: FOA43_003157(LYS21)
BBRX: BRETT_000905(LYS21_1) BRETT_003395(LYS21_2)
OPA: HPODL_02806 HPODL_04767
YLI: 2907696(YALI2_E00847g)
SLB: AWJ20_418(LYS21)
NCR: NCU05526(lys-5)
NTE: NEUTE1DRAFT68872(NEUTE1DRAFT_68872)
SMP: 10807367(SMAC4_00737)
PAN: PODANSg2772
PBEL: QC761_404040(LYS21)
PPSD: QC762_404040(LYS21)
PPSP: QC763_404040(LYS21)
PPSA: QC764_404040(LYS21)
TTT: THITE_2110530
MTM: MYCTH_2307131
CTHR: CTHT_0044760
RTHE: 98126597(VTJ83DRAFT_5361)
MGR: MGG_01092
PPEI: PpBr36_08045
PGRI: PgNI_08149
TMN: UCRPA7_2646
SSCK: SPSK_02501
FGR: FGSG_03993 FGSG_11054
FPU: FPSE_02427 FPSE_05284
FPOA: FPOAC1_006422(LYS1_1) FPOAC1_009794(LYS1_2)
FVN: FVRRES_07028 FVRRES_10448
FVR: FVEG_00366 FVEG_08487 FVEG_11679
FOX: FOXG_01149 FOXG_01159
NHE: NECHADRAFT_104905 NECHADRAFT_90471
FFC: NCS54_00169600 NCS54_00936300
FKR: NCS57_00167300 NCS57_00956000
FMU: J7337_001595(LYS1_1) J7337_010079
TRE: TRIREDRAFT_123471
TRR: M419DRAFT_111054
TATV: 25783463(TrAtP1_002614)
TASP: 36614917(LYS21)
MAW: 19248474(LYS21_2) 19249066(LYS21_1)
MAJ: MAA_04642 MAA_08803
MBRN: 26240320(lys1_2) 26243663(lys1_3)
PCHM: VFPPC_01004 VFPPC_01351
UVI: 66067721(UV8b_06944) 66067784(UV8b_07007)
CMT: CCM_06007
AMUS: LMH87_005390
PLJ: 28886033(PLICBS_007544) 28888981(PLICBS_008533)
PTKZ: JDV02_002478(LYS21)
DCON: 63713765(DCS_01122)
VAL: VDBG_04044 VDBG_07402
VDA: VDAG_01275 VDAG_06110
CFJ: CFIO01_11607
CLUP: CLUP02_13734
CHIG: CH63R_05833
CDET: 87948817(CDEST_12317)
SAPO: SAPIO_CDS8181
ELA: UCREL1_11150
PFY: PFICI_06350 PFICI_09647
SSL: SS1G_14306
BFU: BCIN_14g05400
MBE: MBM_09052
PSCO: LY89DRAFT_684190
GLZ: GLAREA_07760
ANI: ANIA_01990
AFM: AFUA_4G10460
ACT: ACLA_049660
NFI: NFIA_105610
AOR: AO090003001165 AO090124000027
ANG: An04g06210
AFV: AFLA_000502 AFLA_009184
ALUC: AKAW2_51586A(LYS1_2)
ACHE: ACHE_10778S(LYS1_1)
APUU: APUU_21064S(LYS1_1)
PCS: N7525_005048
PDP: PDIP_24800
POU: POX_f08046
PPSF: 300792716(PFLUO_LOCUS6638)
TMF: EYB26_005247
TRG: TRUGW13939_02747
CIM: CIMG_09081
CPW: 9692533(LYS1_2)
URE: UREG_05150
ABE: ARB_01923
TVE: TRV_02108
PBL: PAAG_07089
PBN: PADG_01615
AJE: HCAG_06098
BGH: BDBG_02311
PNO: SNOG_08956
PTE: PTT_15621
PTRR: 6347463(PtrM4_036810)
BZE: COCCADRAFT_101614
BSC: COCSADRAFT_32571
BOR: COCMIDRAFT_95545
AALT: CC77DRAFT_1052185
ADAC: 96082853(ACET3X_002531)
ARAB: EKO05_0009236
ZTR: MYCGRDRAFT_110230
PFJ: MYCFIDRAFT_86887
FFU: CLAFUR5_12241
CBET: CB0940_11003
BCOM: BAUCODRAFT_39689
NPA: UCRNP2_8181
TML: GSTUM_00009173001
SPO: 2539815(lys4)
SOM: SOMG_00682(lys4)
CNE: CND01200
CNB: CNBD5100
CNG: CNAG_00992
CGI: CGB_D3430W
CDEU: CNBG_0572
CDEC: 89987318(IAS62_000542)
CTEG: 91987164(I308_100306)
CBAS: 91980594(I312_100546)
CDEP: 91088103(L203_103893)
KMG: 30162028(I203_107462)
KNE: 92183145(IAR55_005887)
KDJ: 28965791(I303_101772)
KBI: 30208427(I302_100653)
KPIN: 30174755(I206_101644)
KSH: 87954058(IL334_001927)
KER: 91104803(V865_006002)
KSN: 43592463(CI109_106630)
KBO: 90018229(L199_007245)
KEP: 91092655(L201_001983)
TMS: TREMEDRAFT_44559
TASA: A1Q1_00939
CCAC: CcaHIS019_0703000(LYS21)
PPL: POSPLDRAFT_89192
TVS: TRAVEDRAFT_110523
DSQ: DICSQDRAFT_45747
PCO: PHACADRAFT_159123
SHS: STEHIDRAFT_90937
HIR: HETIRDRAFT_316739
ADL: AURDEDRAFT_112769
FME: FOMMEDRAFT_76994
GTR: GLOTRDRAFT_112070
RSX: RhiXN_02664
LBC: LACBIDRAFT_291144
CCI: CC1G_06438
ABP: AGABI1DRAFT114278(AGABI1DRAFT_114278)
ABV: AGABI2DRAFT191298(AGABI2DRAFT_191298)
PCUB: JR316_0006175
MRR: Moror_4622
MORE: E1B28_011484(LYS4_1)
SCM: SCHCO_02503178(SCHCODRAFT_02503178)
CPUT: CONPUDRAFT_80635
SLA: SERLADRAFT_468311
WSE: WALSEDRAFT_42693
WIC: J056_002016
UMA: UMAG_04115
PFP: PFL1_06052
SGRA: EX895_001568
MGL: MGL_3987
MRT: MRET_4216
MSYM: MSY001_2206
MVES: 80901056(LYS4_2)
PGR: PGTG_01903
PTRC: PtA15_10A706
PSTR: Pst134EA_019740
MLR: MELLADRAFT_50387
RIE: OCT59_004379
MBR: MONBRDRAFT_34312
SRE: PTSG_03420
NGR: NAEGRDRAFT_34642
THAR: T8K17_00425
ADE: Adeh_1436
ACP: A2cp1_2511
AFW: Anae109_2393
ANK: AnaeK_2424
AORY: AMOR_52870
APAU: AMPC_18610
SCOR: J3U87_19125(lysS)
PSEU: Pse7367_2223
CYC: PCC7424_0947
CYJ: Cyan7822_1791
NFL: COO91_05563
NED: HUN01_23180(lysS)
NCF: ANSO36C_26370
NCN: BZZ01_06000
CAU: Caur_0328
CHL: Chy400_0353
CAG: Cagg_3603
HAU: Haur_3301
CALL: OZ401_003952
TTR: Tter_2761
LEK: hrd7_27850
CAP: CLDAP_04770
KBS: EPA93_38780
KBB: ccbrp13_35950
THUG: KNN16_06535(lysS)
PMET: G4Y79_18420(lysS)
DRA: DR_1238
DGE: Dgeo_1257
DDR: Deide_13980
DMR: Deima_1358
DGO: DGo_CA1416
DPD: Deipe_2766
DSW: QR90_11530
DCH: SY84_02355
DAB: AUC44_09460
DPU: SU48_09295
DEZ: DKM44_08475(lysS)
DWU: DVJ83_05005(lysS)
DFC: DFI_09345
DEIN: DAAJ005_07905(lysS)
DGA: DEGR_18060
DPH: EHF33_05040(lysS)
DRB: N0D28_09395(lysS)
DAH: DAETH_17180
DAQU: M8445_11600(lysS)
DTAE: LAJ19_07725(lysS)
DMB: E5F05_12480(lysS)
DEID: HLB42_11315(lysS)
TRA: Trad_1388
TTH: TT_C1550
TTJ: TTHA1914(TTHA1914)
TTS: Ththe16_1914
TTL: TtJL18_1996
TSC: TSC_c01850(lysS1)
THC: TCCBUS3UF1_21080
TOS: Theos_1940
TAQ: TO73_0091
TBC: A0O31_00877
TANT: KNN15_05095(lysS)
TBF: KQ693_03535(lysS)
MRB: Mrub_2729
MRE: K649_08890
MTAI: Mtai_v1c23280
MSV: Mesil_0445
OPR: Ocepr_1779
MHD: Marky_0673
 » show all
Reference
PMID:21895798
  Authors
Quezada H, Marin-Hernandez A, Aguilar D, Lopez G, Gallardo-Perez JC, Jasso-Chavez R, Gonzalez A, Saavedra E, Moreno-Sanchez R
  Title
The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 82:578-90 (2011)
DOI:10.1111/j.1365-2958.2011.07832.x
Reference
PMID:18524920
  Authors
Quezada H, Aranda C, DeLuna A, Hernandez H, Calcagno ML, Marin-Hernandez A, Gonzalez A
  Title
Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae.
  Journal
Microbiology 154:1656-67 (2008)
DOI:10.1099/mic.0.2008/017103-0
  Sequence
[sce:YDL182W YDL131W]
Reference
PMID:19776021
  Authors
Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC
  Title
Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
  Journal
J Biol Chem 284:35769-80 (2009)
DOI:10.1074/jbc.M109.046821
  Sequence
[spo:2539815]
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