KEGG   ORTHOLOGY: K01705
Entry
K01705                      KO                                     
Symbol
LYS4
Name
homoaconitate hydratase [EC:4.2.1.36]
Pathway
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Reaction
R04371  homoisocitrate hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K01705  LYS4; homoaconitate hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.36  homoaconitate hydratase
     K01705  LYS4; homoaconitate hydratase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K01705
Other DBs
COG: COG1048
GO: 0004409
Genes
SCE: YDR234W(LYS4)
SEUB: DI49_0416
SPAO: SPAR_D04320
AGO: AGOS_ABL106C
ERC: Ecym_5123
KLA: KLLA0_C15125g
KMX: KLMA_30527(LYS4)
LTH: KLTH0E10582g
VPO: Kpol_1031p57
ZRO: ZYRO0A10076g
CGR: 2890081(GVI51_K10813)
NCS: NCAS_0B02660(NCAS0B02660)
NDI: NDAI_0C05030(NDAI0C05030)
TPF: TPHA_0L01150(TPHA0L01150)
TBL: TBLA_0A01460(TBLA0A01460)
TGB: HG536_0H01840
TDL: TDEL_0B01800(TDEL0B01800)
KAF: KAFR_0E02730(KAFR0E02730)
KNG: KNAG_0A04240(KNAG0A04240)
ZMK: HG535_0F05020
SLUD: SCDLUD_001925
DHA: DEHA2F07238g
PIC: PICST_88705(LYS4)
PGU: PGUG_01420
SPAA: SPAPADRAFT_58782(LYS4)
LEL: PVL30_004416(LYS4)
LBG: 92209228(LODBEIA_P40320)
CAL: CAALFM_C404410CA(LYS4)
CTP: CTRG_03911
COT: CORT_0B00840
CDU: CD36_44080
CTEN: 18246180(LYS4)
CLU: CLUG_00676
CLUS: A9F13_17g00583
CAUR: CJI96_0000218
ASAU: 88171718(PUMCH_000650)
PPA: PAS_chr4_0795
PKZ: C5L36_0B00600
BNN: FOA43_001879(LYS4)
BBRX: BRETT_004628(LYS4)
OPA: HPODL_02077
YLI: 2912118(YALI2_E01707g)
SLB: AWJ20_348(LYS4)
NCR: NCU08898(lys-6)
NTE: NEUTE1DRAFT58933(NEUTE1DRAFT_58933)
SMP: 10804255(SMAC4_05116)
PAN: PODANSg8469
PBEL: QC761_206510(LYS4)
PPSD: QC762_0038220(LYS4)
PPSP: QC763_206510(LYS4)
PPSA: QC764_206510(LYS4)
TTT: THITE_2124288
MTM: MYCTH_2301648
CTHR: CTHT_0069590
RTHE: 98124910(VTJ83DRAFT_3843)
MGR: MGG_04842
PPEI: PpBr36_03207
PGRI: PgNI_01490
TMN: UCRPA7_611
SSCK: SPSK_03952
FGR: FGSG_10949
FPU: FPSE_06063
FPOA: FPOAC1_009694(LYS4) FPOAC1_012803
FVN: FVRRES_10333
FVR: FVEG_11644
FOX: FOXG_12892
NHE: NECHADRAFT_103327 NECHADRAFT_78315 NECHADRAFT_95300
FFC: NCS54_01005400
FKR: NCS57_00218100 NCS57_00999500
FMU: J7337_010041(LYS4)
TRE: TRIREDRAFT_81570
TRR: M419DRAFT_142874
TASP: 36612066(LYS4)
MAW: 19251867(LYS4_3) 19253319(LYS4_1)
MAJ: MAA_04686 MAA_09361
MBRN: 26240367(LYS4_1) 26243995(LYS4_0)
PCHM: VFPPC_00805
CMT: CCM_07793
AMUS: LMH87_002766
PLJ: 28892921(PLICBS_009087)
PTKZ: JDV02_004274(LYS4)
VAL: VDBG_00257
VDA: VDAG_08540
CFJ: CFIO01_08629
CLUP: CLUP02_07655
CHIG: CH63R_04010 CH63R_10446
CDET: 87941043(CDEST_04540) 87943557(CDEST_07054)
SAPO: SAPIO_CDS2378 SAPIO_CDS2954
ELA: UCREL1_5880
PFY: PFICI_04889
SSL: SS1G_01026
BFU: BCIN_14g00430(Bclys4)
MBE: MBM_05638
PSCO: LY89DRAFT_738951
GLZ: GLAREA_01173
ANI: ANIA_06521
AFM: AFUA_5G08890
ACT: ACLA_011660
NFI: NFIA_078420
AOR: AO090701000041
ANG: An15g00350
AFV: AFLA_004530
ALUC: AKAW2_60650A(LYS4)
ACHE: ACHE_50239A(LYS4)
APUU: APUU_10764A(LYS4)
PCS: N7525_011096
PDP: PDIP_05800
POU: POX_c04492
TMF: EYB26_009661
TRG: TRUGW13939_08882
CIM: CIMG_02639
CPW: 9696652(LYS4)
URE: UREG_03117
ABE: ARB_04155
TVE: TRV_03936
PBL: PAAG_03612
PBN: PADG_06215
AJE: HCAG_06854
BGH: BDBG_09384
PNO: SNOG_01131(SNOG_01129 SNOG_01130)
PTE: PTT_19520
PTRR: 6341958(PtrM4_095890)
BZE: COCCADRAFT_82932
BSC: COCSADRAFT_152920
BOR: COCMIDRAFT_86014
AALT: CC77DRAFT_1042638
ADAC: 96086369(ACET3X_006047)
ARAB: EKO05_0008657
ZTR: MYCGRDRAFT_68535
PFJ: MYCFIDRAFT_202095
FFU: CLAFUR5_03230
CBET: CB0940_03357
BCOM: BAUCODRAFT_34146
NPA: UCRNP2_10443
TML: GSTUM_00011608001
SPO: 2542867(lys2)
SOM: SOMG_02039(lys2)
CNE: CNK00580
CNB: CNBK2910
CNG: CNAG_02565
CGI: CGB_K3700C
CDEU: CNBG_3213
CDEC: 89991558(IAS62_004787)
CTEG: 91991915(I308_105059)
CBAS: 91985534(I312_105489)
CDEP: 91088695(L203_104485)
KMG: 30164303(I203_106012)
KNE: 92183516(IAR55_006258)
KDJ: 28964336(I303_100634)
KBI: 30206874(I302_103771)
KPIN: 30168931(I206_100765)
KSH: 87952916(IL334_000785)
KER: 91105912(V865_007111)
TMS: TREMEDRAFT_44947
TASA: A1Q1_04925
CCAC: CcaHIS019_0702660(LYS4)
TVS: TRAVEDRAFT_150870
DSQ: DICSQDRAFT_155148
PCO: PHACADRAFT_252820
SHS: STEHIDRAFT_72757
HIR: HETIRDRAFT_314980
PSQ: PUNSTDRAFT_66471
ADL: AURDEDRAFT_112541
FME: FOMMEDRAFT_76165
GTR: GLOTRDRAFT_107515
RSX: RhiXN_03086
LBC: LACBIDRAFT_184939
CCI: CC1G_14391
ABP: AGABI1DRAFT59676(AGABI1DRAFT_59676)
ABV: AGABI2DRAFT184036(AGABI2DRAFT_184036)
PCUB: JR316_0006214
MRR: Moror_4605
MORE: E1B28_011496(LYS4_2)
SCM: SCHCO_02541718(SCHCODRAFT_02541718)
CPUT: CONPUDRAFT_119840
SLA: SERLADRAFT_468242
WSE: WALSEDRAFT_59020
WIC: J056_004489
UMA: UMAG_10689
PFP: PFL1_04410
SGRA: EX895_000383
MGL: MGL_3298
MRT: MRET_2395
MSYM: MSY001_3108
PGR: PGTG_09399
PTRC: PtA15_8A618
PSTR: Pst134EA_025611
MLR: MELLADRAFT_105205
RIE: OCT59_029567
MBR: MONBRDRAFT_32374
SRE: PTSG_09627
ACAN: ACA1_061650
PIF: PITG_12462
PSOJ: PHYSODRAFT_562967
SPAR: SPRG_03993
NGR: NAEGRDRAFT_80875
UAM: UABAM_01973
ABA: Acid345_2965
IAL: IALB_1150
MRO: MROS_2220
CABY: Cabys_582
CALL: OZ401_000503(lysF)
 » show all
Reference
PMID:23106124
  Authors
Fazius F, Shelest E, Gebhardt P, Brock M
  Title
The fungal alpha-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.
  Journal
Mol Microbiol 86:1508-30 (2012)
DOI:10.1111/mmi.12076
  Sequence
[sce:YDR234W]
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