KEGG   ORTHOLOGY: K01780
Entry
K01780                      KO                                     
Symbol
cntK
Name
histidine racemase [EC:5.1.1.24]
Pathway
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Module
M00949  Staphylopine biosynthesis, L-histidine => staphylopine
Reaction
R12313  histidine racemase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K01780  cntK; histidine racemase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.1  Acting on amino acids and derivatives
    5.1.1.24  histidine racemase
     K01780  cntK; histidine racemase
Other DBs
COG: COG0253
Genes
SDO: SD1155_03785
CGEO: CGEO_0432
CBLA: CBLAS_1471
CCOR: CCORG_1384
DDS: Ddes_1977
DFI: AXF13_11085
DPG: DESPIGER_2298
DEF: CNY67_02250
DFL: DFE_2755
DSB: LN040_15640
DVU: DVU_2746
DVL: Dvul_0561
DVM: DvMF_1168
DVG: Deval_2536
CLIH: KPS_001439
BWS: WCP94_000890
DBA: Dbac_1615
DOA: AXF15_03775
DESU: NLA06_05780
THEW: TDMWS_15840
TPI: TREPR_0956
TAZ: TREAZ_1278
BSON: S101395_03013
BHA: BH2071
LYB: C3943_14835
LMAC: I6G82_11185
VNE: CFK40_16070
MEKU: HUW50_21740
ACHP: QR721_11240
BBAD: K7T73_01185
AND: GRQ40_16010
SAU: SA2258
SAV: SAV2470
SAW: SAHV_2454
SAH: SaurJH1_2546
SAJ: SaurJH9_2497
SAM: MW2394
SAS: SAS2361
SAR: SAR2557
SAC: SACOL2479
SAX: USA300HOU_2461
SAA: SAUSA300_2414
SAO: SAOUHSC_02770
SAE: NWMN_2367
SAD: SAAV_2536
SUU: M013TW_2430(cntK)
SUV: SAVC_11220
SUE: SAOV_2520c
SUJ: SAA6159_02367(cntK)
SUK: SAA6008_02511(dapF)
SUC: ECTR2_2327
SUT: SAT0131_02669
SUQ: HMPREF0772_10719
SUZ: MS7_2483
SUD: ST398NM01_2520
SUX: SAEMRSA15_23680
SUW: SATW20_25980
SUG: SAPIG2520
SUF: SARLGA251_22500
SAUA: SAAG_00296
SAUE: RSAU_002308
SAUN: SAKOR_02454
SAUS: SA40_2218
SAUU: SA957_2302
SAUG: SA268_2375
SAUZ: SAZ172_2573
SAUT: SAI1T1_2018400
SAUJ: SAI2T2_1018410
SAUK: SAI3T3_1018400
SAUQ: SAI4T8_1018410
SAUV: SAI7S6_1018400
SAUW: SAI5S5_1018340
SAUX: SAI6T6_1018340
SAUY: SAI8T7_1018380
SAUF: X998_2454
SAB: SAB2353c
SUY: SA2981_2407
SAUB: C248_2520
SAUM: BN843_25100
SAUC: CA347_2549
SAUR: SABB_02982
SAUI: AZ30_12970
SAUD: CH52_06635
SAMS: NI36_12280
SUH: SAMSHR1132_22950
SER: SERP2375
SEP: SE_0201
SEPP: SEB_00129
SEPS: DP17_1263
SSD: SPSINT_0076
SDT: SPSE_2401
SDP: NCTC12225_02596
SWA: A284_00410
SPAS: STP1_1306
SXY: BE24_11765
SXL: SXYLSMQ121_0067
SXO: SXYL_00068
SHU: SHYC_11655
SCAP: AYP1020_1968
SSCH: LH95_11160
SSCZ: RN70_11910
SAGQ: EP23_10510(cntK)
SLZ: B5P37_06425
SFQ: C7J90_03765
SCHR: DWB92_11730(cntK)
SSH: NCTC13712_02422
SLLO: ISP08_00440(cntK)
SRAI: LN051_10985(cntK)
SPSD: JMB28_00735(cntK)
SEDA: MNY58_00455(cntK)
SROT: ML435_11885(cntK)
SFF: FOB90_08230(cntK)
SSTE: SAMEA4384403_1088
BBE: BBR47_28200
BFM: BP422_09275
BAGR: BA6348_01055
BPAB: PSE45_01825
BREH: HP435_01960
GYM: GYMC10_2835
PMS: KNP414_01893
PMQ: PM3016_2178
PMW: B2K_11195
PAEA: R70723_16820
PNP: IJ22_24990
PVO: PVOR_17339
PLW: D5F53_15610
PCHI: PC41400_19310
PBAC: HUB98_11430
PTRI: KDC22_17085
PALO: E6C60_2224
PUI: PUW25_11730
PAMY: P9222_12190
PNK: AASFL403_06940
PPAB: KET34_28295
PEZZ: HW560_11445
PELG: ACJ7K1_03510
PAJN: JNUCC32_11030
PANA: BBH88_13395
SURE: SporoP32a_07155
SPOS: DV702_00150
LTI: JW886_02775
CTC: CTC_02312
CTET: BN906_02523
CACE: CACET_c28190
CFM: BJL90_00610 BJL90_20915
CCOH: SAMEA4530647_1986
CLOO: RCG18_26320
CRS: FQB35_12585
PROQ: P6M73_10415
OVA: OBV_13890
OHI: H8790_01515
VFA: MM35RIKEN_15870
DMT: DESME_14740
FWA: DCMF_00910 DCMF_25690
ALAC: JYE50_00510
AHC: JYE49_01350
CBAF: JS518_08295
BYL: A4V09_20630
BHAN: CGC63_14650
BLAU: DQQ01_02000
BPRO: PMF13cell1_01326
BCOC: BLCOC_52500(cntK)
BLAR: LC508_21065
CPRO: CPRO_28700(dapF_2)
ANV: RBQ60_14505
VPY: HZI73_24760
AMIC: Ami3637_14300
ETM: CE91St48_30360
AMT: Amet_2050
TEB: T8CH_1255
TEP: TepRe1_0771
TAE: TepiRe1_0835
BACG: D2962_04760
KME: H0A61_01263
PED: ING2D1G_0166
PHAR: NCTC13077_00489
PEQU: O6R05_00740
PGK: M9426_02310
MFOM: VZL98_01880
TIS: P3962_06630
MED: MELS_2057
MHW: ACT01_00490
MEG: DKB62_02595
MMAX: LCQ47_11300
SSG: Selsp_0678
AFN: Acfer_1540
AIN: Acin_0749
FBS: N510_000947(cntK)
GPD: GII33_20960
ARTQ: CGQ24_13620
AAI: AARI_10880
GAR: AOZ07_05765
GLU: F0M17_05425
GNC: QQS42_05440
PAEY: KUF55_05510
PSDS: K1T35_28810
APRE: CNX65_19690
AMI: Amir_3920
UME: RM788_04620
PLK: CIK06_26255
FNU: FN1732
FNC: HMPREF0946_01324
FNT: HMPREF0405_00071
FUS: HMPREF0409_01840
FNE: FSDG_02337
FHW: RN87_01210
FPD: CTM68_03690
FNF: BSQ88_10095
FPEI: C4N17_08665
FCI: I6I83_02190
FPOL: ERS445057_00315
CSOM: MKD34_13680
 » show all
Reference
PMID:27230378
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2470]
LinkDB

KEGG   ENZYME: 5.1.1.24
Entry
EC 5.1.1.24                 Enzyme                                 
Name
histidine racemase;
cntK (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
Sysname
histidine racemase
Reaction(IUBMB)
L-histidine = D-histidine [RN:R12313]
Reaction(KEGG)
R12313
Substrate
L-histidine [CPD:C00135]
Product
D-histidine [CPD:C06419]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History
EC 5.1.1.24 created 2019
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K01780  histidine racemase
Genes
SDO: SD1155_03785
CGEO: CGEO_0432
CBLA: CBLAS_1471
CCOR: CCORG_1384
DDS: Ddes_1977
DFI: AXF13_11085
DPG: DESPIGER_2298
DEF: CNY67_02250
DFL: DFE_2755
DSB: LN040_15640
DVU: DVU_2746
DVL: Dvul_0561
DVM: DvMF_1168
DVG: Deval_2536
CLIH: KPS_001439
BWS: WCP94_000890
DBA: Dbac_1615
DOA: AXF15_03775
DESU: NLA06_05780
THEW: TDMWS_15840
TPI: TREPR_0956
TAZ: TREAZ_1278
BSON: S101395_03013
BHA: BH2071
LYB: C3943_14835
LMAC: I6G82_11185
VNE: CFK40_16070
MEKU: HUW50_21740
ACHP: QR721_11240
BBAD: K7T73_01185
AND: GRQ40_16010
SAU: SA2258
SAV: SAV2470
SAW: SAHV_2454
SAH: SaurJH1_2546
SAJ: SaurJH9_2497
SAM: MW2394
SAS: SAS2361
SAR: SAR2557
SAC: SACOL2479
SAX: USA300HOU_2461
SAA: SAUSA300_2414
SAO: SAOUHSC_02770
SAE: NWMN_2367
SAD: SAAV_2536
SUU: M013TW_2430(cntK)
SUV: SAVC_11220
SUE: SAOV_2520c
SUJ: SAA6159_02367(cntK)
SUK: SAA6008_02511(dapF)
SUC: ECTR2_2327
SUT: SAT0131_02669
SUQ: HMPREF0772_10719
SUZ: MS7_2483
SUD: ST398NM01_2520
SUX: SAEMRSA15_23680
SUW: SATW20_25980
SUG: SAPIG2520
SUF: SARLGA251_22500
SAUA: SAAG_00296
SAUE: RSAU_002308
SAUN: SAKOR_02454
SAUS: SA40_2218
SAUU: SA957_2302
SAUG: SA268_2375
SAUZ: SAZ172_2573
SAUT: SAI1T1_2018400
SAUJ: SAI2T2_1018410
SAUK: SAI3T3_1018400
SAUQ: SAI4T8_1018410
SAUV: SAI7S6_1018400
SAUW: SAI5S5_1018340
SAUX: SAI6T6_1018340
SAUY: SAI8T7_1018380
SAUF: X998_2454
SAB: SAB2353c
SUY: SA2981_2407
SAUB: C248_2520
SAUM: BN843_25100
SAUC: CA347_2549
SAUR: SABB_02982
SAUI: AZ30_12970
SAUD: CH52_06635
SAMS: NI36_12280
SUH: SAMSHR1132_22950
SER: SERP2375
SEP: SE_0201
SEPP: SEB_00129
SEPS: DP17_1263
SSD: SPSINT_0076
SDT: SPSE_2401
SDP: NCTC12225_02596
SWA: A284_00410
SPAS: STP1_1306
SXY: BE24_11765
SXL: SXYLSMQ121_0067
SXO: SXYL_00068
SHU: SHYC_11655
SCAP: AYP1020_1968
SSCH: LH95_11160
SSCZ: RN70_11910
SAGQ: EP23_10510(cntK)
SLZ: B5P37_06425
SFQ: C7J90_03765
SCHR: DWB92_11730(cntK)
SSH: NCTC13712_02422
SLLO: ISP08_00440(cntK)
SRAI: LN051_10985(cntK)
SPSD: JMB28_00735(cntK)
SEDA: MNY58_00455(cntK)
SROT: ML435_11885(cntK)
SFF: FOB90_08230(cntK)
SSTE: SAMEA4384403_1088
BBE: BBR47_28200
BFM: BP422_09275
BAGR: BA6348_01055
BPAB: PSE45_01825
BREH: HP435_01960
GYM: GYMC10_2835
PMS: KNP414_01893
PMQ: PM3016_2178
PMW: B2K_11195
PAEA: R70723_16820
PNP: IJ22_24990
PVO: PVOR_17339
PLW: D5F53_15610
PCHI: PC41400_19310
PBAC: HUB98_11430
PTRI: KDC22_17085
PALO: E6C60_2224
PUI: PUW25_11730
PAMY: P9222_12190
PNK: AASFL403_06940
PPAB: KET34_28295
PEZZ: HW560_11445
PELG: ACJ7K1_03510
PAJN: JNUCC32_11030
PANA: BBH88_13395
SURE: SporoP32a_07155
SPOS: DV702_00150
LTI: JW886_02775
CTC: CTC_02312
CTET: BN906_02523
CACE: CACET_c28190
CFM: BJL90_00610 BJL90_20915
CCOH: SAMEA4530647_1986
CLOO: RCG18_26320
CRS: FQB35_12585
PROQ: P6M73_10415
OVA: OBV_13890
OHI: H8790_01515
VFA: MM35RIKEN_15870
DMT: DESME_14740
FWA: DCMF_00910 DCMF_25690
ALAC: JYE50_00510
AHC: JYE49_01350
CBAF: JS518_08295
BYL: A4V09_20630
BHAN: CGC63_14650
BLAU: DQQ01_02000
BPRO: PMF13cell1_01326
BCOC: BLCOC_52500(cntK)
BLAR: LC508_21065
CPRO: CPRO_28700(dapF_2)
ANV: RBQ60_14505
VPY: HZI73_24760
AMIC: Ami3637_14300
ETM: CE91St48_30360
AMT: Amet_2050
TEB: T8CH_1255
TEP: TepRe1_0771
TAE: TepiRe1_0835
BACG: D2962_04760
KME: H0A61_01263
PED: ING2D1G_0166
PHAR: NCTC13077_00489
PEQU: O6R05_00740
PGK: M9426_02310
MFOM: VZL98_01880
TIS: P3962_06630
MED: MELS_2057
MHW: ACT01_00490
MEG: DKB62_02595
MMAX: LCQ47_11300
SSG: Selsp_0678
AFN: Acfer_1540
AIN: Acin_0749
FBS: N510_000947(cntK)
GPD: GII33_20960
ARTQ: CGQ24_13620
AAI: AARI_10880
GAR: AOZ07_05765
GLU: F0M17_05425
GNC: QQS42_05440
PAEY: KUF55_05510
PSDS: K1T35_28810
APRE: CNX65_19690
AMI: Amir_3920
UME: RM788_04620
PLK: CIK06_26255
FNU: FN1732
FNC: HMPREF0946_01324
FNT: HMPREF0405_00071
FUS: HMPREF0409_01840
FNE: FSDG_02337
FHW: RN87_01210
FPD: CTM68_03690
FNF: BSQ88_10095
FPEI: C4N17_08665
FCI: I6I83_02190
FPOL: ERS445057_00315
CSOM: MKD34_13680
 » show all
Reference
1  [PMID:27230378]
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2470]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.24
IUBMB Enzyme Nomenclature: 5.1.1.24
ExPASy - ENZYME nomenclature database: 5.1.1.24
BRENDA, the Enzyme Database: 5.1.1.24
LinkDB

KEGG   REACTION: R12313
Entry
R12313                      Reaction                               
Name
histidine racemase
Definition
L-Histidine <=> D-Histidine
Equation
C00135 <=> C06419
Reaction class
RC00302  C00135_C06419
Enzyme
5.1.1.24
Pathway
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Module
M00949  Staphylopine biosynthesis, L-histidine => staphylopine
Brite
Enzymatic reactions [BR:br08201]
 5. Isomerase reactions
  5.1  Racemases and epimerases
   5.1.1  Acting on amino acids and derivatives
    5.1.1.24
     R12313  L-Histidine <=> D-Histidine
Orthology
K01780  histidine racemase [EC:5.1.1.24]
LinkDB

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