KEGG ORTHOLOGY: K01830

ORTHOLOGY: K01830

Entry

K01830                      KO

Symbol

PTGDS

Name

prostaglandin-H2 D-isomerase [EC:5.3.99.2]

Pathway

map00590

Arachidonic acid metabolism

map01100

Metabolic pathways

Reaction

R02266

(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate D-isomerase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K01830  PTGDS; prostaglandin-H2 D-isomerase
Enzymes [BR:ko01000]
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.99  Other intramolecular oxidoreductases
    5.3.99.2  prostaglandin-D synthase
     K01830  PTGDS; prostaglandin-H2 D-isomerase

Other DBs

GO:

0004667

Genes

HSA:	5730(PTGDS)

PTR:	100610452(PTGDS)

PPS:	100983768(PTGDS)

GGO:	101130674(PTGDS)

PON:	100459419(PTGDS)

PPYG:

129043999(PTGDS)

NLE:	100592404(PTGDS)

HMH:	116475895(PTGDS)

SSYN:

129478658(PTGDS)

MCC:	707990(PTGDS)

MCF:	101926100(PTGDS)

MTHB:

126937093

MNI:	105471957(PTGDS)

CSAB:

103239597(PTGDS)

CATY:

105580598(PTGDS)

PANU:

101014485(PTGDS)

TGE:	112607932(PTGDS)

MLEU:

105543271(PTGDS)

RRO:	104669645(PTGDS)

RBB:	108542875(PTGDS)

TFN:	117099127(PTGDS)

PTEH:

111553052(PTGDS)

CANG:

105522694(PTGDS)

CJC:	100394436(PTGDS)

SBQ:	101033870(PTGDS)

CIMI:

108287273(PTGDS)

ANAN:

105712244(PTGDS)

CSYR:

103252365(PTGDS)

MMUR:

105882279(PTGDS)

LCAT:

123645602(PTGDS)

PCOQ:

105818695(PTGDS)

OGA:	100950128(PTGDS)

MMU:	19215(Ptgds)

MCAL:

110289823(Ptgds)

MPAH:

110319252(Ptgds)

RNO:	25526(Ptgds)

MCOC:

116089822(Ptgds)

ANU:	117711955(Ptgds)

ASYL:

127684084(Ptgds)

CGE:	100762704(Ptgds)

MAUA:

101824112(Ptgds)

PROB:

127222600(Ptgds)

PLEU:

114692791(Ptgds)

MORG:

121462938(Ptgds)

MFOT:

126509396

AAMP:

119820027(Ptgds)

NGI:	103741183(Ptgds)

HGL:	101699559(Ptgds)

CPOC:

100732586(Ptgds)

CCAN:

109700635(Ptgds)

DORD:

106002549(Ptgds)

PLOP:

125351590(Ptgds) 125351610

NCAR:

124964994

MMMA:

107159182(Ptgds)

ITI:	101957380(Ptgds)

OCU:

100009453

OPI:	101527586(PTGDS)

TUP:	102482208(PTGDS)

GVR:	103593501(PTGDS)

CFA:	403740(PTGDS)

CLUD:

112677471(PTGDS)

VVP:	112906884(PTGDS)

VLG:	121472603(PTGDS)

NPO:	129510804(PTGDS)

AML:	100474593(PTGDS)

UMR:	103675299(PTGDS)

UAH:	113248563(PTGDS)

UAR:

123796332

ELK:

111145644

LLV:

125083971

MPUF:

101688664(PTGDS)

MNP:	132024221(PTGDS)

MLK:	131813086(PTGDS)

NVS:	122916814(PTGDS)

ORO:	101372918(PTGDS)

EJU:	114201737(PTGDS)

ZCA:	113934631(PTGDS)

MLX:	118018176(PTGDS)

NSU:	110581230(PTGDS)

LWW:	102736858(PTGDS)

FCA:	493852(PTGDS)

PYU:	121020253(PTGDS)

PBG:	122475079(PTGDS)

PVIV:

125150917(PTGDS)

LRUF:

124522454

LGF:	123593728(PTGDS)

AJU:

106989498

PTG:	102962017(PTGDS)

PPAD:

109258819(PTGDS)

PUC:

125923564

PLEZ:

122205372(PTGDS)

HHV:	120226456(PTGDS)

BTA:	286858(PTGDS)

BOM:	102274981(PTGDS)

BIU:	109566622(PTGDS)

BBUB:

102399256(PTGDS)

BBIS:

104983136(PTGDS)

CHX:

106502686

OAS:	443192(PTGDS)

BTAX:

128056492(PTGDS)

CSUM:

138087160(PTGDS)

ODA:	120860791 120860793

CCAD:

122442416(PTGDS)

MREE:

136162623(PTGDS)

OVR:	110134094(PTGDS)

MBEZ:

129539832(PTGDS)

SSC:	397456(PTGDS)

CFR:	102512148(PTGDS)

CBAI:

105068598(PTGDS)

CDK:	105106194(PTGDS)

VPC:	102544576(PTGDS)

BACU:

103013138(PTGDS)

LVE:	103088196(PTGDS)

OOR:	101280808(PTGDS)

LALB:

132522709(PTGDS)

DLE:	111177005(PTGDS)

PCAD:

102995908(PTGDS)

PSIU:

116755645(PTGDS)

NASI:

112411275(PTGDS)

ECB:	100067921(PTGDS)

EPZ:	103567817(PTGDS)

EAI:	106845529(PTGDS)

MYB:	102238842(PTGDS)

MYD:	102773498(PTGDS)

MMYO:

118655295(PTGDS)

MDT:	132212627(PTGDS)

MYUM:

139020587(PTGDS)

PKL:	118707098(PTGDS) 118707100

EFUS:

103295970(PTGDS)

MNA:	107536157(PTGDS)

DRO:	112306362(PTGDS)

SHON:

118980156(PTGDS)

AJM:	119036146(PTGDS)

PDIC:

114509203(PTGDS)

PHAS:

123823481(PTGDS)

MMF:	118630280(PTGDS)

PPAM:

129079527(PTGDS)

HAI:	109382064(PTGDS)

RFQ:	117031469(PTGDS)

PALE:

102889838(PTGDS)

PGIG:

120599799(PTGDS)

PVP:	105298611(PTGDS)

RAY:	107503129(PTGDS)

MJV:	108406841(PTGDS)

TOD:	119231099(PTGDS)

SARA:

101538647(PTGDS)

SFUM:

130040688(PTGDS)

SETR:

126020962(PTGDS)

LAV:	100672974(PTGDS)

TMU:

101357448

ETF:	115869382(PTGDS)

DNM:	101444161(PTGDS)

MDO:	100022407(PTGDS)

GAS:	123235156(PTGDS)

SHR:	100913465(PTGDS)

AFZ:

127549118

PCW:	110205092 110205307(PTGDS)

TVP:	118836335 118842310 118844745(PTGDS)

PBRV:

138176714(PTGDS)

OAA:	100085740(PTGDS) 100681151

TACU:

119946613

GGA:	374110(PTGDS)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

103819086(PTGDS)

PMOA:

120507367(PTGDS)

PRUF:

ATRC:

GFR:

FAB:

OMA:	130260230(PTGDS)

PHI:	102105998(PTGDS)

PMAJ:

107212132(PTGDS)

CCAE:

111936898

CBRC:

103614999(PTGDS)

ACOE:

138119767

ETL:	114064151(PTGDS)

ZAB:

102065537

ZLE:	135455085(PTGDS)

ACHL:

103809507(PTGDS)

SVG:	106855997(PTGDS)

MMEA:

HRT:

SATI:

CCIC:

FPG:

FCH:

CCRI:

104162965(PTGDS)

NNT:	104401924(PTGDS)

SHAB:

ACUN:

TALA:

ACHC:

HLE:

AGEN:

HHAR:

GCL:

LDI:	104350317(LCN2)

MNB:

103772826

DPUB:

104300177(PTGDS)

EGZ:	104123982(PTGDS)

NNI:	104018370(PTGDS)

PCRI:

104035008(PTGDS)

PCAO:

104053756(PTGDS)

AFOR:

CLV:

MUI:

PLET:

EHS:	104515735(PTGDS)

CMAC:

CUCA:

BREG:

CPEA:

CVF:	104291070(PTGDS)

RTD:

128917532

CRID:

134523836

AAM:	106494228 106494242

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:	102385594 102386173

AMJ:	102562368(PAEP) 102565053(PTGDS)

CPOO:

109313780

GGN:

109292834

PSS:

102450917

CMY:	102940625(PTGDS)

CCAY:

125623455(PTGDS)

DCC:	119844271(PTGDS)

CPIC:

101934059

TST:

117867186

CABI:

116820783(PTGDS)

MRV:	120386556(PTGDS)

ACS:

100559774

ASAO:

132766347 132768572(PTGDS)

PVT:	110078794 110087472

SUND:

PBI:

PMUR:

CTIG:

TSR:	106541988 106541989

PGUT:

APRI:

PTEX:

VKO:

PMUA:

PRAF:

128404784 128407921 128414864(PTGDS) 128416654

ZVI:	118077608 118078896 118081537 118094065

HCG:	128338785 128338796

GJA:

107115167

STOW:

125442120

EMC:	129341898 129342571

XLA:	100301961(obp.S) 444723(ptgds.S)

XTR:	594897(obp) 779694(ptgds)

NPR:

RTEM:

BBUF:

BGAR:

PWL:	138301191 138301192

MUO:	115472606 115473573

DRE:	336492(ptgdsb.1) 751701(ptgdsb.2) 767759(zgc:153704)

SRX:	107725160 107727228 107732854 107741844 107744241 107756329 107758556

SANH:

107654290 107658663 107665866 107672532 107679760 107683250 107685120 107686711 107695405

SGH:	107549197 107562205 107567131 107569009 107587556 107591480 107595145 107597660

CCAR:

109049068 109062909(lcn15) 109062915 109070664 109083424 109097728 109102342 109102343

CAUA:

113042283 113049663 113054068 113066012 113068038 113069928 113079611 113083296 113109443 113109647 113117913

CGIB:

127946148 127957115(zgc:153704) 127976510 127988131 128013389

PTET:

122329791 122333155 122344924(zgc:153704)

LROH:

127155595 127166179(zgc:153704) 127179580

OMC:	131523592 131533472 131541486(zgc:153704)

PPRM:

120471653 120471715 120475942

RKG:	130078710(zgc:153704) 130087653

MAMB:

125246196 125258486 125266328(zgc:153704) 125269051

CIDE:

127498404 127505814 127512284(zgc:153704)

CERY:

137006289 137014000 137033856(zgc:153704) 137034499

MASI:

127423707 127432111 127434281 127440053(zgc:153704)

TROS:

130546946 130546983 130551420(zgc:153704)

TDW:	130413110 130413305(ptgdsb.1) 130419550(zgc:153704)

MANU:

129426299 129439494(zgc:153704)

PDAB:

135732819(zgc:153704) 135740057

IPU:	108276825(ptgdsa)

PHYP:

113544146(lcn2)

SMEO:

124393820(ptgdsa)

TFD:	113653011(ptgdsa)

CGAR:

128511800 128511808 128519787 128519982

TRN:	134301288(ptgdsb.1)

AMEX:

103023737(ptgdsb.1) 103024938(zgc:153704) 103033485(ptgdsa) 103034887 125805764

CMAO:

118799132(ptgdsb.1) 118814941 118814948(zgc:153704)

EEE:	113575964(lcn2) 113589053

CHAR:

105905217 105911389

SPIL:

134066326

TRU:	101062110 101063432

TFS:

130513862

TNG:	GSTEN00015480G001 GSTEN00019032G001

LCO:	104922352 104923743(lcn2) 104935632

NCC:	104941618(ptgds) 104965992

TBEN:

117484000 117484001 117484002 117490435(zgc:153704)

CGOB:

115019068 115025749

PGEO:

117440975 117441021 117458911 117465748 117465841 117465933 117466029 139432866

GACU:

117535351 117535360 117535361 117536870(zgc:153704) 117537177 117557060 117557061 117557063

EMAC:

134883986(ptgdsb.1)

ELY:	117264846(ptgdsb.1) 117272082(zgc:153704)

EFO:	125881556 125898286(zgc:153704)

PLEP:

121952434 121960716

SLUC:

116038035 116038036 116064761(zgc:153704)

ECRA:

117937544 117955497(zgc:153704)

ESP:	116671975 116700811

PFLV:

114549326 114567219

GAT:	120811942 120821590(zgc:153704)

PPUG:

119198444 119215597(zgc:153704)

AFB:	129110769(ptgdsb.1) 129113311(zgc:153704)

CLUM:

117742743(zgc:153704) 117749479(ptgdsb.1)

PSWI:

130191804(zgc:153704) 130191987 130206230(ptgdsb.1)

CANA:

137785313 137788779 137802365(zgc:153704)

CVE:	137871800 137876688(zgc:153704)

MSAM:

119908631(ptgdsb.1)

SCHU:

122866780

CUD:	121518648(zgc:153704) 121527518(ptgdsb.1)

SPUL:

138595878 138600392

LMIX:

132994365(ptgdsb.1)

ALAT:

119008668(ptgdsb.1)

ASTR:

137587583 137605858(zgc:153704)

MZE:	101469027 101469325 101469534 101473393 101487197 112430756 112430757 112430758 112431174 112431514

ONL:	100690012 100710144(ptgdsl1) 100710404 100712094 100712323(ptgdsl2) 109198956

OAU:	116325627 116328271(ptgdsb.1) 116335208(ptgdsa) 116336190 116336191 120434046

OLA:	101165663 101166755

OML:	112140174(zgc:153704) 112151488

CSAI:

133423640(ptgdsb.1)

XMA:

102228717

XCO:	114136698 114153257

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122823927 122844471

PPRL:

129364693

CVG:

107104609

CTUL:

119772519

GMU:	124857793 124876326(zgc:153704)

NFU:	107372365(lcn2) 107382981 107387046

KMR:	108236998(zgc:153704) 108243171(ptgdsb.1)

ALIM:

106514563(lcn2) 106517545 106526130

NWH:	119426655(ptgdsb.1)

AOCE:

111569761(ptgdsb.1) 111573811(zgc:153704) 111586188(ptgdsa)

EJA:

138196454

BFRE:

138624972(ptgdsb.1) 138629529

MCEP:

124995946(ptgdsb.1)

CSEM:

103376894 103389059(lcn2) 103395470

POV:	109626153(lcn2) 109628511 109629662 109629665

SSEN:

122765619 122779508(zgc:153704)

SSOE:

131455655

HHIP:

117754100 117774898(zgc:153704)

HSP:	118098241 118098242 118122140(zgc:153704)

PPLT:

128425608 128425708

SMAU:

118291468 118291469

LCF:	108893582(zgc:153704) 108900765

SDU:	111234505 111237257 111238768(lcn2)

SLAL:

111652505 111662868 111666185

XGL:	120790219 120802765(zgc:153704)

HCQ:	109515561 109517954

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110158582 110158583 110160949 110174145

ENY:	140360346 140364504(ptgdsb.1)

MALB:

109952639 109963705

BSPL:

114853691 114853692

SJO:

128382466

SSCO:

134002395(ptgdsb.1)

GMH:

115537335

SASA:

106563592(CYTB) 106578378(LIPO) 106590529 106590538(LIPO) 106590877 106603057(LIPO)

STRU:

115151993 115154790 115195428 115195429 115204396

OTW:	112227670 112231219 112232819(lcn15) 112236894 112243157 121838729

OMY:	100135934 110489613 110510074 110525451(lcn15) 110534089 110535402 118966787

OGO:	123991268 124006644 124007048 124039508 124039509

ONE:	115101421 115104995 115121505 115135541

OKI:	109873233 109874020 109900128 109909669

OKE:	118361688 118378716 118378720 118383315 118385034

OMM:	135517175 135518516 135522768 135544191 135550332

OCLA:

139366685 139366687 139366688 139366934 139388764 139418616 139418617 139420298

SALP:

111950579 111953833 111964330 111972949 111973843

SNH:	120021743 120028049 120050312 120050315 120056622

CCLU:

121541932 121549788 121570476 121579565 121579568

ELS:	105022025 105022026 105022027 105027674

OEP:	134013840(zgc:153704) 134035225

SFM:

108923719

AANG:

118234847(zgc:153704)

AROT:

135263106(zgc:153704)

LOC:	102695969(ptgds)

PSPA:

121298740 121304385 121309609

ARUT:

117433562 117433918 117964789

LCM:

HOC:

LERI:

BROR:

DMK:

SDM:	118182011 118182012 118182013

» show all

Reference

PMID:1385416

Authors

White DM, Mikol DD, Espinosa R, Weimer B, Le Beau MM, Stefansson K

Title

Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase.

Journal

J Biol Chem 267:23202-8 (1992)

Sequence

[hsa:5730]

Reference

PMID:20667974

Authors

Zhou Y, Shaw N, Li Y, Zhao Y, Zhang R, Liu ZJ

Title

Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules.

Journal

FASEB J 24:4668-77 (2010)
DOI:10.1096/fj.10-164863

LinkDB

DBGET integrated database retrieval system