ORTHOLOGY: K02186
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Entry
K02186 KO
Symbol
CASP2
Name
caspase 2 [EC:
3.4.22.55
]
Pathway
map04210
Apoptosis
Disease
H00768
Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
K02186 CASP2; caspase 2
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins
K02186 CASP2; caspase 2
01002 Peptidases and inhibitors
K02186 CASP2; caspase 2
Enzymes [BR:
ko01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.55 caspase-2
K02186 CASP2; caspase 2
Protein phosphatases and associated proteins [BR:
ko01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
K02186 CASP2; caspase 2
Peptidases and inhibitors [BR:
ko01002
]
Cysteine peptidases
Family C14: caspase family
K02186 CASP2; caspase 2
BRITE hierarchy
Genes
HSA:
835
(CASP2)
PTR:
463804
(CASP2)
PPS:
100984572
(CASP2)
GGO:
101128958
(CASP2)
PON:
100454928
(CASP2)
PPYG:
129039974
(CASP2)
NLE:
100599260
(CASP2)
HMH:
116814469
(CASP2)
SSYN:
129485127
(CASP2)
MCC:
704339
(CASP2)
MCF:
102128712
(CASP2)
MTHB:
126951062
MNI:
105471186
(CASP2)
CSAB:
103227412
(CASP2)
CATY:
105584645
(CASP2)
PANU:
101006276
(CASP2)
TGE:
112620420
(CASP2)
MLEU:
105546620
(CASP2)
RRO:
104674919
(CASP2)
RBB:
108544234
(CASP2)
TFN:
117072364
(CASP2)
PTEH:
111521444
(CASP2)
CJC:
100402493
(CASP2)
SBQ:
101040888
(CASP2)
CIMI:
108291112
(CASP2)
ANAN:
105713745
(CASP2)
CSYR:
103271043
(CASP2)
MMUR:
105873292
(CASP2)
LCAT:
123647584
(CASP2)
PCOQ:
105815440
(CASP2)
OGA:
100963099
(CASP2)
MMU:
12366
(Casp2)
MCAL:
110296109
(Casp2)
MPAH:
110316173
(Casp2)
RNO:
64314
(Casp2)
MCOC:
116098811
(Casp2)
ANU:
117720880
(Casp2)
ASYL:
127678550
(Casp2)
MUN:
110558418
(Casp2)
CGE:
100689445
(Casp2)
MAUA:
101832827
(Casp2)
PROB:
127214265
(Casp2)
PLEU:
114698017
(Casp2)
MORG:
121435560
(Casp2)
MFOT:
126496292
126515102
AAMP:
119806861
(Casp2)
NGI:
103730398
(Casp2)
HGL:
101712106
(Casp2)
CPOC:
100735399
(Casp2)
CCAN:
109697479
(Casp2)
DORD:
105989490
(Casp2)
DSP:
122105905
(Casp2)
DMER:
138809882
(Casp2)
PLOP:
125347263
(Casp2)
NCAR:
124991564
MMMA:
107148984
(Casp2)
ITI:
101963912
(Casp2)
OCU:
100101590
OPI:
101521745
(CASP2)
OCZ:
121170787
(CASP2)
TUP:
102498970
(CASP2)
GVR:
103583508
103600454
(CASP2)
CFA:
482737
(CASP2)
CLUD:
112650936
(CASP2)
VVP:
112934814
(CASP2)
VLG:
121488914
(CASP2)
NPO:
129515895
(CASP2)
AML:
100474060
(CASP2)
UMR:
103668980
(CASP2)
UAH:
113265500
(CASP2)
UAR:
123788834
(CASP2)
ELK:
111152078
LLV:
125080608
MPUF:
101674782
(CASP2)
MNP:
132015616
(CASP2)
MLK:
131829885
(CASP2)
NVS:
122905159
(CASP2)
ORO:
101384305
(CASP2)
EJU:
114211737
(CASP2)
ZCA:
113911860
(CASP2)
MLX:
118021190
(CASP2)
NSU:
110582867
(CASP2)
LWW:
102726152
FCA:
101088318
(CASP2)
PYU:
121028175
(CASP2)
PCOO:
112866313
(CASP2)
PBG:
122488449
(CASP2)
PVIV:
125154533
(CASP2)
LRUF:
124524191
LGF:
123607027
(CASP2)
AJU:
106980767
PTG:
102948856
(CASP2)
PPAD:
109269169
(CASP2)
PUC:
125930233
PLEZ:
122212931
(CASP2)
HHV:
120239002
(CASP2)
BTA:
531419
(CASP2)
BOM:
102272786
(CASP2)
BIU:
109557747
(CASP2)
BBUB:
102407716
(CASP2)
BBIS:
104984335
(CASP2)
CHX:
102183569
(CASP2)
OAS:
101115025
(CASP2)
BTAX:
128046509
(CASP2)
CSUM:
138079923
(CASP2)
ODA:
120877702
(CASP2)
CCAD:
122438770
(CASP2)
MREE:
136170795
(CASP2)
OVR:
110139585
(CASP2)
MBEZ:
129552733
(CASP2)
SSC:
100521118
(CASP2)
CFR:
102508934
(CASP2)
CBAI:
105069548
(CASP2)
CDK:
105105559
(CASP2)
VPC:
102534115
(CASP2)
BACU:
103017857
(CASP2)
BMUS:
118900947
(CASP2)
LVE:
103085195
(CASP2)
OOR:
101271768
(CASP2)
LALB:
132524499
(CASP2)
GMF:
115851790
(CASP2)
DDP:
132431262
(CASP2)
DLE:
111177325
(CASP2)
PCAD:
102982974
(CASP2)
PSIU:
116759648
(CASP2)
PPHC:
136128074
(CASP2)
NASI:
112408444
(CASP2)
ECB:
100050611
(CASP2)
EPZ:
103562808
(CASP2)
EAI:
106833854
(CASP2)
MYB:
102264102
(CASP2)
MYD:
102774985
(CASP2)
MMYO:
118666310
(CASP2)
MLF:
102430756
(CASP2)
MDT:
132242860
(CASP2)
MYUM:
139016280
(CASP2)
PKL:
118714167
(CASP2)
EFUS:
103297265
(CASP2)
MNA:
107523761
(CASP2)
DRO:
112316166
(CASP2)
SHON:
118997005
(CASP2)
AJM:
119060599
(CASP2)
PDIC:
114507769
(CASP2)
PHAS:
123831001
(CASP2)
MMF:
118620397
(CASP2)
PPAM:
129063024
(CASP2)
HAI:
109376369
(CASP2)
RFQ:
117018233
(CASP2)
PALE:
102895485
(CASP2)
PGIG:
120600953
(CASP2)
PVP:
105304116
(CASP2)
RAY:
107516993
(CASP2)
MJV:
108404389
(CASP2)
TOD:
119248048
(CASP2)
SARA:
101557433
(CASP2)
SFUM:
130032318
(CASP2)
SETR:
126011185
(CASP2)
LAV:
100661506
(CASP2)
TMU:
101361957
ETF:
101643551
(CASP2)
DNM:
101434852
(CASP2)
MDO:
100011923
(CASP2)
GAS:
123249181
(CASP2)
SHR:
100919881
(CASP2)
AFZ:
127538416
PCW:
110216131
(CASP2)
TVP:
118851528
(CASP2)
PBRV:
138160696
(CASP2)
MLAO:
141492818
(CASP2)
OAA:
100074924
(CASP2)
TACU:
119920992
(CASP2)
GGA:
395857
(CASP2)
PCOC:
116239978
(CASP2)
MGP:
100544010
(CASP2)
CJO:
107319105
(CASP2)
TPAI:
128089920
(CASP2)
LMUT:
125703775
(CASP2)
NMEL:
110398088
(CASP2)
APLA:
101794734
(CASP2)
ACYG:
106048728
(CASP2)
CATA:
118247815
(CASP2)
AFUL:
116502385
(CASP2)
TGU:
100221143
(CASP2)
LSR:
110480764
(CASP2)
SCAN:
103827175
(CASP2)
PMOA:
120506440
(CASP2)
OTC:
121335940
(CASP2)
PRUF:
121354699
(CASP2)
ATRC:
139592809
(CASP2)
GFR:
102043378
(CASP2)
FAB:
101805629
(CASP2)
OMA:
130259885
(CASP2)
PHI:
102108085
(CASP2)
PMAJ:
107210261
(CASP2)
CCAE:
111938007
(CASP2)
CCW:
104687148
(CASP2)
CBRC:
103617161
(CASP2)
ACOE:
138111775
(CASP2)
ETL:
114065685
(CASP2)
ZAB:
102066161
(CASP2)
ZLE:
135453218
(CASP2)
ACHL:
103803479
(CASP2)
SVG:
106863051
(CASP2)
MMEA:
130574813
(CASP2)
HRT:
120749592
(CASP2)
SATI:
136375526
(CASP2)
CCIC:
134041116
(CASP2)
FPG:
101915905
(CASP2)
FCH:
102048179
(CASP2)
CCRI:
104154467
(CASP2)
NNT:
104404497
(CASP2)
SHAB:
115601597
(CASP2)
ACUN:
113482177
(CASP2)
TALA:
104355497
(CASP2)
ACHC:
115343994
(CASP2)
HALD:
104313373
(CASP2)
HLE:
104831793
(CASP2)
AGEN:
126048890
HHAR:
128145185
(CASP2)
GCL:
127025043
CSTI:
104560146
LDI:
104339704
(CASP2)
MNB:
103770425
(CASP2)
DPUB:
104299465
(CASP2)
PPUS:
135182070
(CASP2)
AVIT:
104277165
BRHI:
104498820
(CASP2)
EGZ:
104126551
(CASP2)
NNI:
104009575
(CASP2)
PCRI:
104033567
(CASP2)
PCAO:
104044624
(CASP2)
PADL:
103920778
(CASP2)
AFOR:
103905468
(CASP2)
FGA:
104069274
(CASP2)
CBOR:
142088748
(CASP2)
GSTE:
104254525
(CASP2)
CBOY:
140659571
(CASP2)
MAME:
142413791
(CASP2)
CLV:
102095337
(CASP2)
CNIC:
136001624
(CASP2)
MUI:
104541760
(CASP2)
PLET:
104617509
(CASP2)
EHS:
104502630
(CASP2)
CMAC:
104480293
(CASP2)
CUCA:
104064349
(CASP2)
BREG:
104641376
(CASP2)
OHA:
104327124
(CASP2)
ACAR:
104529932
(CASP2)
CPEA:
104389354
(CASP2)
CVF:
104293293
(CASP2)
RTD:
128916194
(CASP2)
CRID:
134524248
(CASP2)
LMIC:
141744877
(CASP2)
AAM:
106497280
(CASP2)
AROW:
112973008
(CASP2)
NPD:
112951710
(CASP2)
TGT:
104564902
(CASP2)
DNE:
112990867
(CASP2)
SCAM:
104150733
(CASP2)
ASN:
102377638
(CASP2)
AMJ:
102558644
(CASP2)
CPOO:
109318987
(CASP2)
GGN:
109304524
(CASP2)
PSS:
102463164
(CASP2)
CIZ:
142007090
(CASP2)
CMY:
102929343
(CASP2)
CCAY:
125622914
(CASP2)
DCC:
119856680
(CASP2)
CPIC:
101938497
(CASP2)
TST:
117885444
(CASP2)
CABI:
116815538
(CASP2)
MRV:
120375179
(CASP2)
ACS:
100567806
(casp2)
ASAO:
132767561
(CASP2)
PVT:
110091477
(CASP2)
SUND:
121920580
(CASP2)
PBI:
103051794
(CASP2)
PMUR:
107289968
(CASP2)
CTIG:
120306071
(CASP2)
TSR:
106546743
(CASP2)
PGUT:
117661785
(CASP2)
PCAE:
139311050
(CASP2)
APRI:
131191250
(CASP2)
PTEX:
113449589
(CASP2)
NSS:
113424474
(CASP2)
VKO:
123028058
(CASP2)
PMUA:
114587363
(CASP2)
PRAF:
128404674
(CASP2)
ZVI:
118075180
(CASP2)
HCG:
128346770
(CASP2)
GJA:
107115535
(CASP2)
STOW:
125437119
(CASP2)
EMC:
129345207
(CASP2)
XLA:
108697326
397817
(casp2.L)
XTR:
100486813
(casp2)
NPR:
108784894
(CASP2)
RTEM:
120946867
(CASP2)
ACAT:
141105802
(CASP2)
BBUF:
121004327
(CASP2)
BGAR:
122940296
(CASP2)
DTC:
141056315
(CASP2)
PWL:
138303483
(CASP2)
MUO:
115457730
(CASP2)
GSH:
117350599
(CASP2)
DRE:
373118
(casp2)
SRX:
107744674
107748817
SANH:
107685580
107699940
(casp2)
SGH:
107569996
(casp2)
107596737
CCAR:
109085235
109105725
CAUA:
113060139
113116229
CGIB:
127975231
PTET:
122360964
(casp2)
LROH:
127178885
(casp2)
GRF:
141342379
(casp2)
OMC:
131522554
(casp2)
PPRM:
120495040
(casp2)
RKG:
130070457
(casp2)
MAMB:
125244106
(casp2)
CIDE:
127497401
CERY:
137031059
(casp2)
MASI:
127452609
127454323
TROS:
130558401
(casp2)
TDW:
130433295
(casp2)
MANU:
129447765
(casp2)
PDAB:
135751810
(casp2)
IPU:
108268399
IFU:
128610761
(casp2)
PHYP:
113533689
(casp2)
SMEO:
124385013
(casp2)
TFD:
113644153
(casp2)
TVC:
132845859
(casp2)
CGAR:
128520893
(casp2)
NGRA:
132886847
(casp2)
TRN:
134309972
(casp2)
AMEX:
103030250
(casp2)
CMAO:
118817839
(casp2)
EEE:
113575293
(casp2)
CHAR:
105901663
(casp2)
SPIL:
134083069
(casp2)
ASAD:
121721313
(casp2)
TRU:
101072588
(casp2)
TFS:
130532977
(casp2)
TNG:
GSTEN00015350G001
LCO:
104929017
(casp2)
NCC:
104954509
TBEN:
117494759
(casp2)
CGOB:
115021650
(casp2)
PGEO:
117444833
(casp2)
GACU:
117548018
(casp2)
EMAC:
134861861
(casp2)
ELY:
117266305
(casp2)
EFO:
125893125
(casp2)
PLEP:
121945259
(casp2)
SLUC:
116049656
(casp2)
ECRA:
117946229
(casp2)
ESP:
116674610
116691243
(casp2)
PFLV:
114557483
(casp2)
GAT:
120810840
(casp2)
PPUG:
119197234
(casp2)
AFB:
129109534
(casp2)
CLUM:
117745464
(casp2)
PSWI:
130213458
(casp2)
CANA:
137781742
(casp2)
CVE:
137890994
(casp2)
MSAM:
119897458
(casp2)
SCHU:
122882040
(casp2)
CUD:
121513407
(casp2)
SPUL:
138584052
(casp2)
LMIX:
132983043
(casp2)
HTC:
141800534
(casp2)
ALAT:
119006337
(casp2)
ASTR:
137601138
(casp2)
MZE:
101470507
(casp2)
ONL:
100703280
(casp2)
OAU:
116323771
(casp2)
OLA:
101171774
(casp2)
OML:
112143669
(casp2)
CSAI:
133434499
(casp2)
XMA:
102216745
(casp2)
XCO:
114142068
(casp2)
XHE:
116715507
(casp2)
PRET:
103478021
(casp2)
PFOR:
103136717
(casp2)
PLAI:
106952586
(casp2)
PMEI:
106916578
(casp2)
GAF:
122831031
(casp2)
PPRL:
129371227
(casp2)
CVG:
107082265
(casp2)
CTUL:
119783113
(casp2)
GMU:
124866040
(casp2)
NFU:
107379433
(casp2)
KMR:
108235415
(casp2)
ALIM:
106520479
(casp2)
NWH:
119409340
(casp2)
AOCE:
111586367
(casp2)
129350018
EJA:
138194087
(casp2)
BFRE:
138619334
(casp2)
MCEP:
125017067
(casp2)
CSEM:
103387931
(casp2)
POV:
109633282
(casp2)
SSEN:
122774915
(casp2)
SSOE:
131471900
(casp2)
HHIP:
117776801
(casp2)
HSP:
118113201
(casp2)
PPLT:
128449976
(casp2)
SMAU:
118315167
(casp2)
LCF:
108887338
SDU:
111230073
(casp2)
SLAL:
111669846
(casp2)
XGL:
120783990
(casp2)
HCQ:
109515309
(casp2)
SSCV:
125975727
(casp2)
SBIA:
133500714
(casp2)
PEE:
133402081
(casp2)
PTAO:
133479025
(casp2)
BPEC:
110163095
(casp2)
ENY:
140374347
(casp2)
MALB:
109966150
(casp2)
BSPL:
114842940
(casp2)
SJO:
128365841
(casp2)
SSCO:
133982935
(casp2)
TTY:
137191265
(casp2)
GMH:
115554422
(casp2)
SASA:
106576719
106591706
106605831
STRU:
115176571
(casp2)
115187894
OTW:
112225903
(casp2)
112253770
OMY:
110509281
110537322
(casp2)
OGO:
123998118
124006155
ONE:
115140808
(casp2)
OKI:
109868795
109879287
OKE:
118371231
118371240
OMM:
135520608
135521914
OCLA:
139389298
139422046
SALP:
111964847
(casp2)
SNH:
120031202
120047724
SFON:
129837498
129857197
CCLU:
121542975
121586223
ELS:
105019056
(casp2)
OEP:
134023582
(casp2)
SFM:
108924035
(casp2)
PKI:
111833972
(casp2)
AANG:
118213118
(casp2)
AROT:
135240543
(casp2)
CCOG:
133109986
(casp2)
LOC:
102696227
PSPA:
121325365
(casp2)
ARUT:
117425205
(casp2)
PSEX:
120535715
(casp2)
LCM:
102349624
(CASP2)
HOC:
132813150
(casp2)
PMRN:
116958310
(CASP2)
BFO:
118409150
118424979
118425349
118430265
118430471
118432211
BBEL:
109463126
109464943
109469527
109472931
109484124
109486134
109486423
109487213
CIN:
100177955
100185724
SCLV:
120328281
120328394
120328429
120328437
120328561
120330725
120331055
120331321
120331427
120332053
120332057
120333296
120335043
120341081
120347096
AFIL:
140144864
140147196
140162420
BCOO:
119079878
119080014
119083223
FAS:
105264965
DAM:
107043402
SOY:
115885114
AGRG:
126747222
CSET:
123313332
123314254
AGB:
108915730
LDC:
111517097
DVT:
126903458
HHAL:
106679794
106692455
106692462
MQU:
129004008
129004508
TPAL:
117645803
DMK:
116919288
PVM:
113815986
PJA:
122243890
122243891
122244216
122244446
122245056
122245057
122256802
122257482
122257483
122257485
122260554
122263094
122266355
PCHN:
125028142
125029737
125032519
125038516
125038661
125041106
125041107
125041314
PMOO:
119591995
HAME:
121855528
121862919
121867711
121873881
121879450
PCLA:
123745763
123754306
123756154
123763565
PTRU:
123501256
123510132
123516621
HAZT:
108666522
108670568
LSM:
121114714
TCF:
131881781
131882115
PPOI:
119092901
DSV:
119445431
RSAN:
119390615
119390616
119398843
RMP:
119163741
VDE:
111249789
VJA:
111263318
GOE:
100900709
CVS:
136977883
ABRU:
129957227
LPOL:
106461695
LOA:
LOAG_03664
LGI:
LOTGIDRAFT_236948
PVUL:
126827248
126828866
PCAN:
112556116
112556538
112556707
112557443
LSAX:
138978505
138978510
138979061
BGT:
106061941
106067681
GAE:
121372701
121373401
121390165
121390245
121390246
121390247
121390352
121390424
121390558
121390663
HRF:
124110783
124112468
124117145
124117732
124131199
HRJ:
124257484
124265586
124279710
124286221
HASI:
137268046
137268087
HCRA:
139470879
139471145
139473269
CRG:
105318726
105320022
105322339
105325341
136272291
136273523
136273524
136275218
CANU:
128163473
128187084
128189072
CVN:
111133817
111138053
OED:
125655930
125663707
125669632
125676287
MYI:
110449061
110461055
PMAX:
117314630
117314633
117314695
117315454
117345248
AIRR:
138315339
MMER:
123527379
123527584
RPHI:
132724398
132731355
132754183
DPOL:
127841166
MAEA:
128203239
128203365
128245710
OBI:
106869844
106878642
OSN:
115209565
115221437
LJP:
135475453
135475800
LAK:
106156302
106157002
106162784
106178017
106178332
SMM:
Smp_032000
OVI:
T265_00765
EGL:
EGR_04133
EGR_04138
LLON:
135496779
135496867
NVE:
5511249
ADF:
107345198
AMIL:
114961896
MCAZ:
138051510
SPIS:
111329232
111336048
TAES:
123139565
» show all
Taxonomy
UniProt
Reference
PMID:
22531785
Authors
Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dotsch V, Rajalingam K
Title
Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis.
Journal
EMBO J 31:2615-28 (2012)
DOI:
10.1038/emboj.2012.93
Sequence
[hsa:
835
]
Reference
PMID:
20735596
Authors
Sakamaki K, Satou Y
Title
Caspases: evolutionary aspects of their functions in vertebrates.
Journal
J Fish Biol 74:727-53 (2009)
DOI:
10.1111/j.1095-8649.2009.02184.x
Reference
PMID:
18602321
Authors
Chowdhury I, Tharakan B, Bhat GK
Title
Caspases - an update.
Journal
Comp Biochem Physiol B Biochem Mol Biol 151:10-27 (2008)
DOI:
10.1016/j.cbpb.2008.05.010
LinkDB
All DBs
DBGET
integrated database retrieval system
