KEGG   ORTHOLOGY: K02304
Entry
K02304                      KO                                     
Symbol
MET8
Name
precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Reaction
R02864  S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
R03947  S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K02304  MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76  precorrin-2 dehydrogenase
     K02304  MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
 4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.4  sirohydrochlorin ferrochelatase
     K02304  MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Other DBs
COG: COG1648
GO: 0043115 0004325
Genes
SCE: YBR213W(MET8)
SEUB: DI49_1239
SPAO: SPAR_B03110
AGO: AGOS_AAR152W
ERC: Ecym_3081
KLA: KLLA0_C05544g
KMX: KLMA_10243(MET8)
LTH: KLTH0H06820g
VPO: Kpol_530p45
ZRO: ZYRO0C05038g
CGR: 2890446(MET8)
NCS: NCAS_0H01490(NCAS0H01490)
NDI: NDAI_0F01760(NDAI0F01760)
TPF: TPHA_0F02830(TPHA0F02830)
TBL: TBLA_0F02410(TBLA0F02410)
TGB: HG536_0H03770
TDL: TDEL_0G03660(TDEL0G03660)
KAF: KAFR_0G02310(KAFR0G02310)
KNG: KNAG_0M00860(KNAG0M00860)
ZMK: HG535_0G02120
DHA: DEHA2F02706g
PIC: PICST_63116(MET8)
SPAA: SPAPADRAFT_139882
LEL: PVL30_003869(MET8)
LBG: 92208361(LODBEIA_P31650)
CAL: CAALFM_C307210WA(MET8)
CTP: CTRG_05628
COT: CORT_0C00200
CDU: CD36_87130
CTEN: 18247041(MET8)
CLU: CLUG_05268
CLUS: A9F13_14g00396
CAUR: CJI96_0004390
ASAU: 88174217(PUMCH_003153)
PPA: PAS_chr1-4_0222
PKZ: C5L36_0D02750
BNN: FOA43_003079
BBRX: BRETT_005332
OPA: HPODL_05212
YLI: 2912753(YALI2_E01532g)
SLB: AWJ20_4352(MET8)
NCR: NCU07585
NTE: NEUTE1DRAFT77927(NEUTE1DRAFT_77927)
SMP: 10805368(SMAC4_07291)
PAN: PODANSg303
PBEL: QC761_300330(MET8)
PPSD: QC762_300330(MET8)
PPSP: QC763_300330(MET8)
PPSA: QC764_300330(MET8)
TTT: THITE_2116280
MTM: MYCTH_2305681
CTHR: CTHT_0064810
RTHE: 98126447(VTJ83DRAFT_5226)
MGR: MGG_17830
PPEI: PpBr36_04051
PGRI: PgNI_12405
TMN: UCRPA7_5070
SSCK: SPSK_09667
FGR: FGSG_04222
FPU: FPSE_10426
FPOA: FPOAC1_006676
FVN: FVRRES_07295
FVR: FVEG_10412
FOX: FOXG_11407
NHE: NECHADRAFT_70041
FFC: NCS54_00800800
FKR: NCS57_00843600
FMU: J7337_011688
TRE: TRIREDRAFT_54181
TRR: M419DRAFT_32006
TASP: 36616175(TrAFT101_002096)
MAW: 19248599(MET8_1)
MAJ: MAA_02805
MBRN: 26241694(met8)
PCHM: VFPPC_07187
CMT: CCM_04648
AMUS: LMH87_009119
PLJ: 28890908(PLICBS_004764)
PTKZ: JDV02_006592(MET8)
VAL: VDBG_08550
VDA: VDAG_08219
CFJ: CFIO01_05975
CLUP: CLUP02_15823
CHIG: CH63R_05259
CDET: 87942334(CDEST_05831)
SAPO: SAPIO_CDS1496
ELA: UCREL1_7146
PFY: PFICI_05244
SSL: SS1G_14076
BFU: BCIN_12g05710(Bcmet8)
MBE: MBM_00710
PSCO: LY89DRAFT_84129
GLZ: GLAREA_08253
ANI: ANIA_06710
AFM: AFUA_7G05680
ACT: ACLA_007400
NFI: NFIA_026930
AOR: AO090005000430
ANG: An07g02200
AFV: AFLA_003217
ALUC: AKAW2_11934S(MET8)
ACHE: ACHE_60971S(MET8)
APUU: APUU_70240A(MET8)
PCS: N7525_008620
PDP: PDIP_47460
POU: POX_e06188
TMF: EYB26_007388
TRG: TRUGW13939_06971
CIM: CIMG_05467
CPW: 9693140(MET8)
URE: UREG_06259
ABE: ARB_00672
TVE: TRV_05014
PBL: PAAG_00047
PBN: PADG_07214
AJE: HCAG_03974
BGH: BDBG_05735
PNO: SNOG_05850
PTE: PTT_11930
PTRR: 6343370(PtrM4_121630)
BZE: COCCADRAFT_108806
BSC: COCSADRAFT_38220
BOR: COCMIDRAFT_108836
AALT: CC77DRAFT_938306
ADAC: 96086524(ACET3X_006202)
ARAB: EKO05_0000658
ZTR: MYCGRDRAFT_76564
PFJ: MYCFIDRAFT_60255
FFU: CLAFUR5_02481
CBET: CB0940_03310
BCOM: BAUCODRAFT_122397
NPA: UCRNP2_3417
TML: GSTUM_00011202001
SPO: 2543624(met8)
SOM: SOMG_02407(met8)
CNE: CNF00750
CNB: CNBF3830
CNG: CNAG_05898
CGI: CGB_F5530C
CDEU: CNBG_1649
CDEC: 89990575(IAS62_003803)
CTEG: 91990787(I308_103931)
CBAS: 91983795(I312_103750)
CDEP: 91087407(L203_103196)
KMG: 30167760(I203_100091)
KNE: 92184047(IAR55_006789)
KDJ: 28971882(I303_106560)
KBI: 30204493(I302_101412)
KPIN: 30173837(I206_106989)
KSH: 87958256(IL334_006126)
KER: 91103733(V865_004932)
TMS: TREMEDRAFT_35940
TASA: A1Q1_04432
CCAC: CcaHIS019_0211480(MET8)
PPL: POSPLDRAFT_25647 POSPLDRAFT_25648
TVS: TRAVEDRAFT_146160
DSQ: DICSQDRAFT_84170
PCO: PHACADRAFT_256591
SHS: STEHIDRAFT_134062
HIR: HETIRDRAFT_379742
PSQ: PUNSTDRAFT_88347
ADL: AURDEDRAFT_110941
FME: FOMMEDRAFT_132168
GTR: GLOTRDRAFT_76688
RSX: RhiXN_03076
LBC: LACBIDRAFT_146719
CCI: CC1G_01163
ABP: AGABI1DRAFT117978(AGABI1DRAFT_117978)
PCUB: JR316_0003592
MPR: MPER_06565
MORE: E1B28_008890
SCM: SCHCO_02607604(SCHCODRAFT_02607604)
CPUT: CONPUDRAFT_135134
SLA: SERLADRAFT_474462
WSE: WALSEDRAFT_50897
UMA: UMAG_00458
PFP: PFL1_06158
SGRA: EX895_000687
MGL: MGL_2195
MRT: MRET_0314
MSYM: MSY001_1924
MLR: MELLADRAFT_49870
 » show all
Reference
PMID:11980703
  Authors
Schubert HL, Raux E, Brindley AA, Leech HK, Wilson KS, Hill CP, Warren MJ
  Title
The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.
  Journal
EMBO J 21:2068-75 (2002)
DOI:10.1093/emboj/21.9.2068
  Sequence
[sce:YBR213W]
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