Entry
Symbol
entD, pptT
Name
enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:
6.3.2.14 2.7.8.7 ]
Pathway
map01053 Biosynthesis of siderophore group nonribosomal peptides
map01110 Biosynthesis of secondary metabolites
Reaction
R01625 CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase
R07644 2,3-dihydroxybenzoate:L-serine ligase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09103 Lipid metabolism
00074 Mycolic acid biosynthesis
K02362 entD, pptT; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase
09109 Metabolism of terpenoids and polyketides
01053 Biosynthesis of siderophore group nonribosomal peptides
K02362 entD, pptT; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K02362 entD, pptT; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase
Enzymes [BR:ko01000 ]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.8 Transferases for other substituted phosphate groups
2.7.8.7 holo-[acyl-carrier-protein] synthase
K02362 entD, pptT; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.14 enterobactin synthase
K02362 entD, pptT; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase
Polyketide biosynthesis proteins [BR:ko01008 ]
Nonribosomal peptide synthetase (NRPS)
Iterative NRPS
Enterobactin synthetase
K02362 entD, pptT; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase
BRITE hierarchy
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Genes
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Taxonomy UniProt
Reference
Authors
Armstrong SK, Pettis GS, Forrester LJ, McIntosh MA
Title
The Escherichia coli enterobactin biosynthesis gene, entD: nucleotide sequence and membrane localization of its protein product.
Journal
Sequence
Reference
Authors
Gehring AM, Bradley KA, Walsh CT.
Title
Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate.
Journal
Reference
Authors
Chalut C, Botella L, de Sousa-D'Auria C, Houssin C, Guilhot C
Title
The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria.
Journal
Sequence
Reference
Authors
Zimhony O, Schwarz A, Raitses-Gurevich M, Peleg Y, Dym O, Albeck S, Burstein Y, Shakked Z
Title
AcpM, the meromycolate extension acyl carrier protein of Mycobacterium tuberculosis, is activated by the 4'-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.
Journal
LinkDB
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