KEGG   ORTHOLOGY: K03268
Entry
K03268            Tight     KO                                     
Symbol
todC1, bedC1, tcbAa
Name
benzene/toluene/chlorobenzene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11 1.14.12.26]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map00625  Chloroalkane and chloroalkene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00547  Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
Reaction
R03543  benzene,NADH:oxygene 1,2-oxidoreductase
R03559  toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R05429  1,4-dichlorobenzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R06831  1,2,4-trichlorobenzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R06856  chlorobenzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R09151  trichloroethene,NADH:oxygen oxidoreductase (glyoxylate-forming)
R09152  trichloroethene,NADH:oxygen oxidoreductase (formate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K03268  todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha
   00625 Chloroalkane and chloroalkene degradation
    K03268  todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha
   00361 Chlorocyclohexane and chlorobenzene degradation
    K03268  todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha
   00623 Toluene degradation
    K03268  todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.3  benzene 1,2-dioxygenase
     K03268  todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha
    1.14.12.11  toluene dioxygenase
     K03268  todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha
    1.14.12.26  chlorobenzene dioxygenase
     K03268  todC1, bedC1, tcbAa; benzene/toluene/chlorobenzene dioxygenase subunit alpha
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K03268
Other DBs
GO: 0018619 0018624 0018609
Genes
PPF: Pput_2881
PPX: T1E_4266(todC1)
PMON: X969_10930
PMOT: X970_10585
PASI: LG197_17450
BPT: Bpet3738
ATEM: PQV96_18710
AG: AAC43632(tcbAa)
Reference
PMID:8824602
  Authors
Fong KP, Goh CB, Tan HM
  Title
Characterization and expression of the plasmid-borne bedD gene from Pseudomonas putida ML2, which codes for a NAD+-dependent cis-benzene dihydrodiol dehydrogenase.
  Journal
J Bacteriol 178:5592-601 (1996)
DOI:10.1128/JB.178.19.5592-5601.1996
Reference
PMID:2670929
  Authors
Zylstra GJ, Gibson DT
  Title
Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli.
  Journal
J Biol Chem 264:14940-6 (1989)
  Sequence
[ppf:Pput_2881]
Reference
PMID:8626733
  Authors
Werlen C, Kohler HP, van der Meer JR
  Title
The broad substrate chlorobenzene dioxygenase and cis-chlorobenzene dihydrodiol dehydrogenase of Pseudomonas sp. strain P51 are linked evolutionarily to the enzymes for benzene and toluene degradation.
  Journal
J Biol Chem 271:4009-16 (1996)
DOI:10.1074/jbc.271.8.4009
  Sequence
[ag:AAC43632]
LinkDB

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