Entry
Name
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphatase;
gmhB (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate [RN:
R09771 ]
Reaction(KEGG)
Substrate
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate [CPD:
C19879 ];
H2O [CPD:
C00001 ]
Product
D-glycero-alpha-D-manno-heptose 1-phosphate [CPD:
C19880 ];
phosphate [CPD:
C00009 ]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. The in vitro catalytic efficiency of the enzyme from Bacteroides thetaiotaomicron is 6-fold higher with the alpha-anomer than with the beta-anomer [1].
History
EC 3.1.3.83 created 2010
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K03273 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase
Genes
ECOO : ECRM13514_0209(yaeD)
ECOH : ECRM13516_0211(yaeD)
EDJ : ECDH1ME8569_0194(gmhB)
ECOI : ECOPMV1_00207(gmhB)
ENR : H650_19780 H650_19815
REE : electrica_04133(gmhB)
RTG : NCTC13098_06048(gmhB)
CLAP : NCTC11466_03726(gmhB)
KGO : CEW81_08860 CEW81_20025
KIE : NCTC12125_02823(gmhB)
AHN : NCTC12129_01001(gmhB)
METY : MRY16398_45980(gmhB)
PSHI : SAMEA2665130_2458(gmhB)
YPG : YpAngola_A3404(gmhB)
YPI : YpsIP31758_1044(gmhB)
YPQ : DJ40_1345(gmhB) DJ40_3509(gmhB)
YPU : BZ21_2285(gmhB) BZ21_257(gmhB)
YPR : BZ20_1032(gmhB) BZ20_3193(gmhB)
YPC : BZ23_2565(gmhB) BZ23_533(gmhB)
YMO : HRD69_00240(gmhB) HRD69_11010
SMW : SMWW4_v1c38730(gmhB)
SFJ : SAMEA4384070_3873(gmhB)
SOF : NCTC11214_02895(gmhB)
SSAR : SSARUM_003736(gmhB)
PAQU : DMB82_0004690(gmhB)
PARL : PEC302110_31050(gmhB)
DIC : Dpoa569_000813(gmhB)
EHD : ERCIPSTX3056_183(gmhB)
TPTY : NCTC11468_02997(gmhB)
PLU : plu0698 plu4825(wblZ)
PLUM : A4R40_03460 A4R40_24000
PHEI : NCTC12003_03024(gmhB)
PRJ : NCTC6933_03129(gmhB)
LRI : NCTC12151_02727(gmhB)
HIC : NTHIC486_00804(gmhB)
HPIT : NCTC13334_00812(gmhB)
HHZ : NCTC10839_00589(gmhB)
HAEG : NCTC8502_00341(gmhB)
PDAG : 4362423_02018(gmhB)
PSKY : A6B44_04235 A6B44_10005
PATL : KGI96_03470(gmhB) KGI96_09225
ADP : NCTC12871_00931(gmhB)
ALIG : NCTC10568_00502(gmhB)
ASEG : NCTC10977_00588(gmhB)
AVT : NCTC3438_00495(gmhB)
RPNE : NCTC8284_03818(gmhB)
PAET : NCTC13378_00330(gmhB)
VHR : AL538_02585 AL538_13000
VOW : A9237_04865 A9237_15350
VAU : VANGNB10_cI0784(gmhB)
VPL : SA104470976_01859(gmhB)
PGB : H744_1c0472 H744_2c0952
PPRC : PFLCHA0_c00130(gmhB)
PMUD : NCTC8068_00010(gmhB)
PFW : PF1751_v1c00090(gmhB)
PPUU : PputUW4_00006(gmhB)
PALL : UYA_00080 UYA_23030
PTRT : HU722_0001055(gmhB)
PTW : TUM18999_00070(gmhB)
PTAE : NCTC10697_00009(gmhB)
MSHE : MAALD49_07710(gmhB)
SBB : Sbal175_1480 Sbal175_1699
SCAA : TUM17387_22830(gmhB)
ALTR : BM528_01390 BM528_10140
SALH : HMF8227_01597(gmhB)
CBS : COXBURSA331_A0092 COXBURSA331_A0791
LLG : 44548918_00714(gmhB)
LJR : NCTC11533_00691(gmhB)
LWA : SAMEA4504053_2037(gmhB)
LSS : NCTC12082_02840(gmhB)
METL : U737_03515 U737_23155
MEEP : JWZ98_00705(gmhB) JWZ98_02800
MMOB : F6R98_05005(gmhB) F6R98_19240
MEIN : methR_P0084 methR_P2384
MESL : KKZ03_13095(gmhB) KKZ03_15135
TZO : THMIRHAT_19800(gmhB)
TNI : TVNIR_2700(gmhB_[H])
HAXI : HAALTHF_09110n(gmhB)
HAAH : HALA3H3_360037(gmhB)
AEL : NCTC12917_00255(gmhB)
CHJ : NCTC10426_00914(gmhB)
ACII : C4901_01165 C4901_08970
ATY : A9R16_000995(gmhB) A9R16_008840
CDIZ : CEDIAZO_01219(gmhB)
NMQ : NMBM04240196_1974(gmhB)
NMZ : NMBNZ0533_1964(gmhB)
NWE : SAMEA3174300_1172(gmhB)
NZO : SAMEA4504057_0845(gmhB)
NCI : NCTC10296_01034(gmhB)
NCZ : NCTC10294_01354(gmhB)
NANI : NCTC12227_01558(gmhB)
VFF : VITFI_CDS1460 VITFI_CDS2400
ECOR : SAMEA4412678_1626(gmhB)
CHIC : N8I74_04590 N8I74_17920(gmhB)
RPF : Rpic12D_0414 Rpic12D_3805
RMN : TK49_05695 TK49_18680
RWE : KOL96_05255 KOL96_10075(gmhB)
REH : H16_A0520(h16_A0520)
REU : Reut_A0506 Reut_A0723 Reut_B4387
CTI : RALTA_A0476(gmhB2) RALTA_A0586(gmhB1)
CGD : CR3_2151(gmhB) CR3_3415(hisB)
CUP : BKK80_04310 BKK80_17025 BKK80_34250
CUU : BKK79_07955 BKK79_15330
CPAU : EHF44_03155 EHF44_23160
COX : E0W60_13170(gmhB) E0W60_13725
CCAX : KZ686_15535(gmhB) KZ686_17365
CNAN : A2G96_03770 A2G96_04300
BMA : BMA0217 BMA2293(gmhB) BMAA1990
BMV : BMASAVP1_1013 BMASAVP1_A0535(gmhB) BMASAVP1_A2729
BML : BMA10229_A1065(wcbN) BMA10229_A2349
BMN : BMA10247_2171(wcbN) BMA10247_2429
BMAL : DM55_1491(gmhB) DM55_1618 DM55_3804
BMAE : DM78_2663(gmhB) DM78_374 DM78_4373
BMAQ : DM76_1469(gmhB) DM76_1597 DM76_4501
BMAI : DM57_06130 DM57_1068 DM57_2251
BMAF : DM51_1934(gmhB) DM51_21 DM51_3670
BMAZ : BM44_1070(gmhB) BM44_3763 BM44_863
BMAB : BM45_2459(gmhB) BM45_4539 BM45_540
BPS : BPSL0666 BPSL2793(wcbN) BPSS2256
BPM : BURPS1710b_0880 BURPS1710b_A1389
BPL : BURPS1106A_0715 BURPS1106A_3275(wcbN) BURPS1106A_A3042
BPD : BURPS668_0700 BURPS668_3240(wcbN) BURPS668_A3171
BPR : GBP346_A0628 GBP346_A3418
BPSE : BDL_1338 BDL_2652(gmhB) BDL_5730
BPSM : BBQ_2761 BBQ_3849 BBQ_516(gmhB)
BPSU : BBN_2884 BBN_5751 BBN_644(gmhB)
BPSD : BBX_1050(gmhB) BBX_3285 BBX_4897
BPZ : BP1026B_I0517(wcbN) BP1026B_I2858 BP1026B_II2429
BPQ : BPC006_I0700 BPC006_I3323 BPC006_II2992
BPK : BBK_2137(gmhB) BBK_5035 BBK_819
BPSH : DR55_1725(gmhB) DR55_427 DR55_5475
BPSA : BBU_1485 BBU_2769(gmhB) BBU_3734
BPSO : X996_1365(gmhB) X996_34 X996_5246