KEGG ORTHOLOGY: K03984

ORTHOLOGY: K03984

Entry

K03984                      KO

Symbol

SERPINA1, AAT

Name

alpha-1-antitrypsin

Pathway

map04610

Complement and coagulation cascades

Disease

H01103

Alpha-1-antitrypsin deficiency

H01714

Chronic obstructive pulmonary disease (COPD)

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03984  SERPINA1, AAT; alpha-1-antitrypsin
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03984  SERPINA1, AAT; alpha-1-antitrypsin
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03984  SERPINA1, AAT; alpha-1-antitrypsin
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I4: serpin family
   K03984  SERPINA1, AAT; alpha-1-antitrypsin
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K03984  SERPINA1, AAT; alpha-1-antitrypsin

Other DBs

GO:

0004867

Genes

HSA:	5265(SERPINA1)

PTR:	467541(SERPINA1)

PPS:	100990043(SERPINA1)

GGO:

101147918

PON:	100171544(SERPINA1)

NLE:	100585221(SERPINA1)

MCC:	701361(SERPINA1)

MCF:	102134991(SERPINA1)

CSAB:

103229609(SERPINA1)

CATY:

105596621

PANU:

101002028(SERPINA1)

TGE:	112629038(SERPINA1)

RRO:	104679071(SERPINA1)

RBB:

108519103

TFN:	117071481(SERPINA1)

PTEH:

111538258(SERPINA1)

CJC:	100388369(SERPINA1)

SBQ:	101036735(SERPINA1)

CSYR:

103250402(SERPINA1)

MMUR:

105856770(SERPINA1)

OGA:	100959522(SERPINA1)

MMU:	20700(Serpina1a) 20701(Serpina1b) 20702(Serpina1c) 20703(Serpina1d) 20704(Serpina1e)

MCAL:

110306582 110307406

MPAH:

110324428 110324489 110324788

RNO:	24648(Serpina1)

MCOC:

116079772 116080037

MUN:	110542650 110565993

CGE:	100761387(Serpina1)

PLEU:

114706063 119089014

NGI:

103748548

HGL:

101717359

CPOC:

100135614(Serpina3k) 100379265(Sh2b2) 100379266(Apf)

CCAN:

109700260(Serpina1)

DORD:

105983387 105986366 105986455 105986464

DSP:	122118698(Serpina1) 122118749 122118787 122118789

OCU:

100008986

OPI:

101530529

TUP:	102495980(SERPINA1)

CFA:	111097149 480422(SERPINA1)

VVP:	112907345(SERPINA1) 112907352

VLG:	121492491 121493589

AML:

100478918

UMR:

103669781

UAH:	113267162 113267312

UAR:	123803945(SERPINA1)

ELK:

LLV:

MPUF:

ORO:

EJU:	114205398(SERPINA1)

ZCA:

113909083

MLX:

118014694

FCA:	101080897(SERPINA1)

PYU:	121032239(SERPINA1)

PBG:

122469486

PTG:	102965075(SERPINA1)

PPAD:

109274505

AJU:	106977456 113601517

HHV:	120246904 120246917

BTA:	280699(SERPINA1)

BOM:	102280489(SERPINA1)

BIU:	109575576(SERPINA1)

BBUB:

102389600(SERPINA1)

CHX:	102185401(SERPINA1)

OAS:	443388(SERPINA1)

ODA:	120875422(SERPINA1)

CCAD:

122454854(SERPINA1)

SSC:	397688(SERPINA1)

CFR:	102506231(SERPINA1)

CBAI:

105079895(SERPINA1)

CDK:	105095641(SERPINA1)

VPC:	102526448(SERPINA1)

BACU:

103000652(SERPINA1)

LVE:	103082359(SERPINA1)

OOR:	101273903(SERPINA1)

DLE:

111176123

PCAD:

102986488

PSIU:

116748940(SERPINA1)

ECB:

100065068

EPZ:	103562397(SERPINA1)

MYB:	102238599 102238925

MYD:	102766940(SERPINA1)

MMYO:

118659578(SERPINA1) 118659588

MLF:	102440783 102441084

MNA:	107536660 107536661

PKL:	118712244(SERPINA1) 118712245 118712254

HAI:	109382721(SERPINA1)

DRO:	112311466(SERPINA1) 112311528

SHON:

118976667 118976698

AJM:	119037857(SERPINA1)

PDIC:

114492788(SERPINA1)

PHAS:

123808248(SERPINA1)

MMF:	118623640 118641255(SERPINA1)

RFQ:	117023787(SERPINA1)

PALE:

102893714(SERPINA1)

PGIG:

120619650(SERPINA1)

PVP:	105305154(SERPINA1)

RAY:	107511269(SERPINA1)

MJV:	108397489 108398548

TOD:

119238353

SARA:

101543720(SERPINA1)

LAV:	100664453(SERPINA1)

TMU:

101344953

DNM:	101423372 101423918 101425400

GAS:	123235663 123237580

SHR:

PCW:

ZVI:

ARUT:

FCD:

BGT:

SMM:	Smp_003300

» show all

Reference

PMID:25105300

Authors

Shapira MG, Khalfin B, Lewis EC, Parola AH, Nathan I

Title

Regulation of autophagy by alpha1-antitrypsin: "a foe of a foe is a friend".

Journal

Mol Med 20:417-26 (2014)
DOI:10.2119/molmed.2014.00054

Reference

PMID:2985281

Authors

Ciliberto G, Dente L, Cortese R

Title

Cell-specific expression of a transfected human alpha 1-antitrypsin gene.

Journal

Cell 41:531-40 (1985)
DOI:10.1016/S0092-8674(85)80026-X

Sequence

[hsa:5265]

LinkDB

DBGET integrated database retrieval system