KEGG ORTHOLOGY: K04007

ORTHOLOGY: K04007

Entry

K04007                      KO

Symbol

CD46, MCP

Name

membrane cofactor protein

Pathway

map03265

Virion - Ebolavirus, Lyssavirus and Morbillivirus

map03267

Virion - Adenovirus

map04610

Complement and coagulation cascades

map05162

Measles

Disease

H01434

Atypical hemolytic uremic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
    K04007  CD46, MCP; membrane cofactor protein
   03267 Virion - Adenovirus
    K04007  CD46, MCP; membrane cofactor protein
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K04007  CD46, MCP; membrane cofactor protein
09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K04007  CD46, MCP; membrane cofactor protein
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04007  CD46, MCP; membrane cofactor protein
   04090 CD molecules
    K04007  CD46, MCP; membrane cofactor protein
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04007  CD46, MCP; membrane cofactor protein
CD molecules [BR:ko04090]
Proteins
  K04007  CD46, MCP; membrane cofactor protein

Genes

HSA:	4179(CD46)

PTR:	469663(CD46)

PPS:	100974092(CD46)

GGO:	101140080(CD46)

PON:	100174740(CD46)

PPYG:

129025899(CD46)

NLE:	100588200(CD46)

HMH:	116457504(CD46)

SSYN:

129458603(CD46)

MCC:	714082(CD46)

MCF:	102146832(CD46)

MTHB:

126949132

MNI:	105484874(CD46)

CSAB:

103230174(CD46)

CATY:

105577091(CD46)

PANU:

101012656(CD46) 108582425 116272447 116273280

TGE:	112631342(CD46)

MLEU:

105536435(CD46)

RRO:	104664177(CD46)

RBB:	108539537(CD46)

TFN:	117075396 117075399

PTEH:

111531166 113225220

CANG:

105508853(CD46)

CJC:	103789310(CD46)

SBQ:	101044625(CD46)

CIMI:

108302107(CD46)

ANAN:

105722079(CD46)

CSYR:

103270783(CD46)

MMUR:

105868176(CD46)

LCAT:

123626892(CD46)

ERUF:

138375837(CD46)

PCOQ:

105805868(CD46)

OGA:

100947569

MMU:	17221(Cd46)

MCAL:

110299161(Cd46)

MPAH:

110322354(Cd46)

RNO:	29333(Cd46) 365577(Cd46l1)

ANU:	117716205(Cd46) 117724671 117724672

ASYL:

127669189 127697539(Cd46)

MUN:	110551849 110563675(Cd46)

CGE:	100767260 100772491(Cd46)

MAUA:

101837429 101844856(Cd46)

PROB:

127215013 127223975(Cd46)

PLEU:

114687535 114692570

MORG:

121435883(Cd46) 121449285

MFOT:

126498992 126505311

AAMP:

119821696 119827211(Cd46)

NGI:	103727021(Cd46) 103736314

HGL:	101704640(Cd46)

CPOC:

100135498(Cd46) 100731981 100732255

CCAN:

109679858 109685444(Cd46)

DORD:

105986461(Cd46)

DSP:	122109131(Cd46)

DMER:

138841096(Cd46)

PLOP:

125359315(Cd46)

NCAR:

124961796 124989202

MMMA:

107140590(Cd46) 107152038 107152042

ITI:	101972966(Cd46) 106145222

OCU:	100341105 103350986

OPI:	101526861 101535731 101535967

OCZ:	121146244 121146245 121160007(CD46)

TUP:	102496476(CD46)

GVR:	103596046(CD46)

CFA:	102156626 609365

CLUD:

112648318 112648319

VVP:	112907132(CD46) 112912720

VLG:	121492804 121492815(CD46)

NPO:	129505913 129505914 129505915

AML:	105240680 105240681

UMR:	103672496 103672499

UAH:	125283451 125283452 130541820

UAR:	123785801 123785802

ELK:	111162359 111162364

LLV:	125086028 125086032

MPUF:

101686450(CD46)

MNP:	132013193 132025557 132025558

MLK:	131814615 131814652 131826622

NVS:	122918729 122918730

ORO:	101383456(CD46)

ZCA:	113933204 113933205

MLX:	118014263 118014264

NSU:	110574181(CD46)

LWW:	102741547 102750233(CD46)

FCA:	101094152 102899273

PYU:	121026553 121026554

PCOO:

112857650 112857685

PBG:	122475742 122475747

PVIV:

125155672 125155674

LRUF:

124510075 124510076

LGF:	123586562 123587011(CD46)

AJU:	106981799 106981800

PTG:	102964102 102964976

PPAD:

109255263(CD46) 109255311

PUC:

125925801

PLEZ:

122212425 122212426

HHV:	120230484 120230513

BTA:	280851(CD46) 518224 616002 618087

BOM:	102271063 102279256 102279542(CD46)

BIU:	109570212 109570213 109570214 109570419(CD46)

BBUB:

102399908 102400242 102404366

BKE:

129653434

BBIS:

104981886 104986322

CHX:	102169209 102169502 102169786

OAS:	101105935 101122294(CD46) 105611355 105611356

BTAX:

128061313 128061314 128061329 128063408

CSUM:

138090187 138090305 138090306 138090308

ODA:	120880392 120880393 120880427 120880428

CCAD:

122451854(CD46) 122452312 122452313 122452376 122452377

MREE:

136168621 136168622 136169421 136169482

OVR:	110122425 110148103 110148104 110148106

MBEZ:

129551221 129551222(CD46) 129551813

SSC:	100515090 396922(CD46)

CFR:	102508849 102520404 116659312

CBAI:

105075450(CD46) 105078621 105078622

CDK:	105100008 105100009

VPC:	102537934 102538201(CD46) 116279903

BACU:

103000756 103015974 103016259

BMUS:

118881047 118881084 118892282

LVE:	103074903 103089778

OOR:	101289924(CD46) 117197676

LALB:

132509407 132509426

GMF:	115861784 115861785(CD46)

DDP:	132413343 132413508

DLE:	111184601 111184602 111184729

PCAD:

102983561 102987077

PSIU:

116740291 116760669 116760784

PPHC:

136118046 136118053 136118062

NASI:

112403442 112403482

ECB:	100057176 100057335 100057500 100146620

EPZ:	103541407 103556839(CD46) 103562568

EAI:	106840878 106842727 106842728

MYB:	102257782 102260864 102261137 106723853

MYD:	102761602 102762738 107184836 107184837

MMYO:

118666822 118673250 118673252 118673253 118673254 118673464 118673478 118673481

MLF:	102420354 102420676 102436899(CD46) 111824557

MDT:	132211820 132221094 132221095 132221246(CD46) 132221249 132221250 132221251 132221255

MYUM:

138995549 138995884 138996166 138996167 138996170 138996171 138996173 138996174 138996175 138996267(CD46)

PKL:	118721253 118721256 118721259 118721676 118721677 118721678

EFUS:

103290139 103290140 103304228 103304231 114229506 114229821 129147856 129147905 129147915 129147979 129148021

MNA:	107532937(CD46) 107543711 107543712 107545464

DRO:	112296309 112297405 112318278 112318353

SHON:

118980773 118980774 118980776 118980779

AJM:

119058026

PDIC:

114512023 114512111 114512112 114512182 114512184

PHAS:

123813407 123813409 123813592 123818318 123818544 123830179

MMF:	118636933 118637287 118637288 118637745

PPAM:

129062051 129062053 129062054 129062295 129062466

HAI:	109378212 109395298(CD46)

RFQ:	117014326 117014597 117014598 117015037

PALE:

102881105 102895375 102895643 107196408

PGIG:

120589494 120594111 120608470 120608471(CD46) 120608473 120613807

PVP:	105300309 105309267 105309749 105309956 111733966

RAY:

107497882

MJV:

108383984

TOD:

119234696

SFUM:

130019952 130020318 130033349(CD46)

LAV:	104845922(CD46)

TMU:

101358307

ETF:	101655409(CD46)

DNM:	101431910(CD46) 105745149

MDO:

103094472

GAS:

123245324

PCW:	110203604 110203608 110222718

TVP:

PBRV:

PBI:

PRAF:

PHYP:

EEE:

TRU:

TFS:	130521338 130529803

TNG:	GSTEN00023443G001

LCO:

TBEN:

CGOB:

GACU:

EMAC:

PLEP:

121946496(rca2.1)

ECRA:

117947121

ESP:	116691967(cd46)

PFLV:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:	137889024 137889025 137889203

SCHU:

EARM:

SPUL:

LMIX:

PKLU:

OAU:	116321994 116321995

OLA:

101157860

OML:

112159625

CSAI:

133456775(rca2.1)

XMA:	102227137 102229824

XCO:	114140456 114140766

XHE:	116716796 116716852

PRET:

103467808 103467960 108166444

PFOR:

103139159 103139160 103139162

PLAI:

106937164 106937167 106961372

PMEI:

106920496 106920497 106920499

GAF:	122840200 122840209

PPRL:

129376971 129377119 129377127

CVG:

107092108

CTUL:

119784982 119785017 119785018

GMU:	124869078 124870515 124870873 124871157 124871260 124873005

NFU:	107390407 107390408

ALIM:

106519173 106527774 106527775

NWH:

EJA:

BFRE:

CSEM:

POV:

SSEN:

SSOE:

SMAU:

SDU:

SLAL:

XGL:

HCQ:

SBIA:

PEE:

PTAO:

ENY:	140362527 140364334

BSPL:

114859279

SJO:	128357092(rca2.1)

SSCO:

133987818

SASA:

106567155

OTW:

112221824

OMY:	100136105 110532574 118966083

ONE:

OCLA:

SNH:

ELS:

PSPA:

121299897 121299900 121304765

RTP:

CPLA:

CPUN:

HOC:

SCAU:

EAF:

HRJ:

Reference

PMID:3260937

Authors

Lublin DM, Liszewski MK, Post TW, Arce MA, Le Beau MM, Rebentisch MB, Lemons LS, Seya T, Atkinson JP

Title

Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.

Journal

J Exp Med 168:181-94 (1988)
DOI:10.1084/jem.168.1.181

Sequence

[hsa:4179]

Reference

PMID:10843656

Authors

Astier A, Trescol-Biemont MC, Azocar O, Lamouille B, Rabourdin-Combe C

Title

Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.

Journal

J Immunol 164:6091-5 (2000)
DOI:10.4049/jimmunol.164.12.6091

Sequence

[hsa:4179]

LinkDB

DBGET integrated database retrieval system