KEGG ORTHOLOGY: K04309

ORTHOLOGY: K04309

Entry

K04309                      KO

Symbol

LGR4, GPR48

Name

leucine-rich repeat-containing G protein-coupled receptor 4

Pathway

map04310

Wnt signaling pathway

Disease

H01593

Osteoporosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04309  LGR4, GPR48; leucine-rich repeat-containing G protein-coupled receptor 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04309  LGR4, GPR48; leucine-rich repeat-containing G protein-coupled receptor 4
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Others
   R-spondin
    K04309  LGR4, GPR48; leucine-rich repeat-containing G protein-coupled receptor 4

Genes

HSA:	55366(LGR4)

PTR:	451088(LGR4)

PPS:	100995615(LGR4)

GGO:	101140077(LGR4)

PON:	100174574(LGR4)

PPYG:

129007325(LGR4)

NLE:	100586088(LGR4)

HMH:	116476409(LGR4)

SSYN:

129484301(LGR4)

MCC:	701736(LGR4)

MCF:	102119503(LGR4)

MTHB:

126934633

MNI:	105463286(LGR4)

CSAB:

103238557(LGR4)

CATY:

105572785(LGR4)

PANU:

101010542(LGR4)

TGE:	112606222(LGR4)

MLEU:

105528115(LGR4)

RRO:	104671129(LGR4)

RBB:	108517410(LGR4)

TFN:	117079834(LGR4)

PTEH:

111554694(LGR4)

CANG:

105507707(LGR4)

CJC:	100395143(LGR4)

SBQ:	101051750(LGR4)

CIMI:

108311309(LGR4)

ANAN:

105717383(LGR4)

CSYR:

103252122(LGR4)

MMUR:

105860140(LGR4)

LCAT:

123642539(LGR4)

ERUF:

138385232(LGR4)

PCOQ:

105814552(LGR4)

OGA:	100957559(LGR4)

MMU:	107515(Lgr4)

MCAL:

110288929(Lgr4)

MPAH:

110318112(Lgr4)

RNO:	286994(Lgr4)

MCOC:

116090623(Lgr4)

ANU:	117703362(Lgr4)

ASYL:

127685705(Lgr4)

MMIU:

308431391(LGR4)

MUN:	110563796(Lgr4)

CGE:	100752655(Lgr4)

MAUA:

101836849(Lgr4)

PROB:

127221794(Lgr4)

PLEU:

114702109(Lgr4)

PMAV:

102913405(Lgr4)

MORG:

121465594(Lgr4)

MFOT:

126490426

AAMP:

119814766(Lgr4)

CNL:	130881236(Lgr4)

NGI:	103748476(Lgr4)

HGL:	101703145(Lgr4)

CPOC:

100724174(Lgr4)

CCAN:

109695017(Lgr4)

DORD:

105988056(Lgr4)

DSP:	122117662(Lgr4)

DMER:

138834031(Lgr4)

PLOP:

125361582(Lgr4)

NCAR:

124958842

SVUL:

306638657(LGR4)

MMMA:

107135720(Lgr4)

ITI:	101964193(Lgr4)

SCIL:

308641113(LGR4)

MAVE:

308262724(LGR4)

OCU:

100356429

OPI:	101517647(LGR4)

OCZ:	121156389(LGR4)

TUP:	102476671(LGR4)

GVR:	103600021(LGR4)

CFA:	476896(LGR4)

CLUD:

112667786(LGR4)

VVP:	112935014(LGR4)

VLG:	121476044(LGR4)

NPO:	129504915(LGR4)

AML:

100468419

UMR:	103659369(LGR4)

UAH:	113265090(LGR4)

UAR:	123799468(LGR4)

ELK:

111150173

LLV:

125110233

MPUF:

101685894(LGR4)

MNP:	132021826(LGR4)

MLK:	131810624(LGR4)

NVS:	122912799(LGR4)

MMAQ:

308350212(LGR4)

ORO:	101373942(LGR4)

EJU:	114219987(LGR4)

ZCA:	113913924(LGR4)

MLX:	118015714(LGR4)

MANO:

123857280(LGR4)

NSU:	110576252(LGR4)

LWW:	102748710(LGR4)

FCA:	101083964(LGR4)

PYU:	121043627(LGR4)

PCOO:

112865283(LGR4)

PBG:	122483643(LGR4)

PVIV:

125146804(LGR4)

LRUF:

124506301

LGF:	123601519(LGR4)

AJU:

106970276

PTG:	102958163(LGR4)

PPAD:

109271278(LGR4)

PUC:

125935357

PLEZ:

122199726(LGR4)

HHV:	120220098(LGR4)

CCRU:

144229405(LGR4)

BTA:	505423(LGR4)

BOM:	102279144(LGR4)

BIU:	109569617(LGR4)

BJV:	133226905(LGR4)

BBUB:

102393317(LGR4)

BKE:	129629249(LGR4)

BBIS:

104982425(LGR4)

CHX:	102180241(LGR4)

OAS:	101110791(LGR4)

OCAN:

138421362(LGR4)

BTAX:

128060446(LGR4)

CSUM:

138092421(LGR4)

ODA:	120876829(LGR4)

CCAD:

122449521(LGR4)

MREE:

136174113(LGR4)

OVR:	110128092(LGR4)

MBEZ:

129554710(LGR4)

SSC:	100518646(LGR4)

CFR:	102507518(LGR4)

CBAI:

105076785(LGR4)

CDK:	105106910(LGR4)

VPC:	102545158(LGR4)

BACU:

103009907(LGR4)

BMUS:

118899140(LGR4)

LVE:	103082237(LGR4)

OOR:	101281205(LGR4)

LALB:

132525918(LGR4)

GMF:	115857613(LGR4)

DDP:	132429836(LGR4)

SCOO:

307190312(LGR4)

PCRS:

137230338(LGR4)

DLE:	111179823(LGR4)

PCAD:

102987717(LGR4)

PSIU:

116758468(LGR4)

PPHC:

136126582(LGR4)

NASI:

112412880(LGR4)

HAMP:

307055773(LGR4)

ECB:	100072305(LGR4)

EPZ:	103552671(LGR4)

EAI:	106824911(LGR4)

MYB:	102254016(LGR4)

MYD:	102767349(LGR4)

MMYO:

118664941(LGR4)

MLF:	102440394(LGR4)

MDT:	132241078(LGR4)

MYUM:

139019005(LGR4)

PKL:	118713664(LGR4)

EFUS:

103292701(LGR4)

POTS:

308234562(LGR4)

MNA:	107531916(LGR4)

DRO:	112303477(LGR4)

SHON:

118983121(LGR4)

AJM:	119049904(LGR4)

PDIC:

114498614(LGR4)

PHAS:

123810007(LGR4)

MMF:	118628529(LGR4)

PPAM:

129080498(LGR4)

HAI:	109373320(LGR4)

RFQ:	117030259(LGR4)

RHII:

308503295(LGR4)

PALE:

102895571(LGR4)

PGIG:

120605175(LGR4)

PVP:	105293723(LGR4)

RAY:	107512172(LGR4)

MJV:	108393336(LGR4)

TOD:	119255411(LGR4)

SARA:

101538525(LGR4)

SFUM:

130043859(LGR4)

SETR:

126018876(LGR4)

LAV:	100676895(LGR4)

TMU:

101349498

ETF:	101640376(LGR4)

DNM:	101429879(LGR4)

MDO:	100030781(LGR4)

GAS:	123252913(LGR4)

SHR:	100934289(LGR4)

AFZ:

127541069

PCW:	110202020(LGR4)

TVP:	118853024(LGR4)

PBRV:

138163677(LGR4)

MLAO:

141518411(LGR4)

OAA:	100087980(LGR4)

TACU:

119943981(LGR4)

GGA:	428605(LGR4)

PCOC:

116237967(LGR4)

MGP:	100547167(LGR4)

CJO:	107314315(LGR4)

TPAI:

128085292(LGR4)

LMUT:

125694688(LGR4)

NMEL:

110400824(LGR4)

APLA:

101793537(LGR4)

AACU:

137857872(LGR4)

OJA:	118167575(LGR4)

BCLA:

308444357(LGR4)

ACYG:

106033953(LGR4)

ABRC:

308195517(LGR4)

CATA:

118249884(LGR4)

AFUL:

116490090(LGR4)

TGU:	100227176(LGR4)

LSR:	110475136(LGR4)

VMC:	128808765(LGR4)

VCHA:

128790314(LGR4)

AIB:	137476474(LGR4)

SCAN:

103822083(LGR4)

PMOA:

120509860(LGR4)

OTC:	121339823(LGR4)

PRUF:

121363037(LGR4)

ATRC:

139585496(LGR4)

MATE:

118687203(LGR4)

MAEN:

136557617(LGR4)

GFR:	102042918(LGR4)

FAB:	101820676(LGR4)

OMA:	130254275(LGR4)

PHI:	102106325(LGR4)

PMAJ:

107205965(LGR4)

CCAE:

111930480(LGR4)

CBRC:

103624796(LGR4)

ACOE:

138111178(LGR4)

ETL:	114066776(LGR4)

ZAB:	102074064(LGR4)

ZLE:	135449072(LGR4)

ACHL:

103807551(LGR4)

SVG:	106861433(LGR4)

MMEA:

130581591(LGR4)

LCAI:

146436594(LGR4)

HRT:	120753982(LGR4)

SATI:

136362195(LGR4)

CFAI:

136292049(LGR4)

CCIC:

134044844(LGR4)

NNT:	104399312(LGR4)

SHAB:

115607153(LGR4)

POCC:

134161416(LGR4)

PECH:

308221135(LGR4)

FPG:	101921842(LGR4)

FCH:	102055189(LGR4)

FRS:	119154404(LGR4)

CCRI:

104168420(LGR4)

ACUN:

113481236(LGR4)

ANOC:

141965895(LGR4)

SURA:

141950168(LGR4)

TALA:

104359892(LGR4)

ACHC:

115351915(LGR4)

HALD:

104310923(LGR4)

AGEN:

126047568

HHAR:

128152705(LGR4)

BBUT:

142040373(LGR4)

GCL:

127016786

CSTI:

104550411(LGR4)

LDI:	104347591(LGR4)

MNB:	103776183(LGR4)

DPUB:

104301013(LGR4)

PPUS:

135186270(LGR4)

IIN:	128973863(LGR4)

AVIT:

104280950(LGR4)

BRHI:

104496647(LGR4)

EGZ:	104123347(LGR4)

NNI:	104009503(LGR4)

PLEC:

309593333(LGR4)

PCRI:

104031889(LGR4)

PCAO:

104043461(LGR4)

PARX:

142057957(LGR4)

PADL:

103925811(LGR4)

AFOR:

103906864(LGR4)

FGA:	104077537(LGR4)

CBOR:

142088202(LGR4)

GSTE:

104263528(LGR4)

CBOY:

140653192(LGR4)

MAME:

142410105(LGR4)

CLV:	102087677(LGR4)

CNIC:

135989441(LGR4)

NMAY:

308041223(LGR4)

MUI:	104538193(LGR4)

PGUU:

104458541(LGR4)

PLET:

104625063(LGR4)

EHS:	104509441(LGR4)

CMAC:

104476295(LGR4)

CUCA:

104054718(LGR4)

PCUR:

138720970(LGR4)

TEO:	104375108(LGR4)

BREG:

104634171(LGR4)

GAME:

129207212(LGR4)

OHA:	104331815(LGR4)

ACAR:

104521430(LGR4)

CEUR:

306725193(LGR4)

CPEA:

104394644(LGR4)

HEK:	139804401(LGR4)

CVF:	104293218(LGR4)

RTD:	128908930(LGR4)

CRID:

134514774(LGR4)

LMIC:

141742853(LGR4)

NARQ:

141465239(LGR4)

AAM:	106498323(LGR4)

AROW:

112969636(LGR4)

NPD:	112948795(LGR4)

TGT:	104579053(LGR4)

DNE:	112996288(LGR4)

SCAM:

104147073(LGR4)

ASN:	102382222(LGR4)

AMJ:	102567979(LGR4)

CPOO:

109321045(LGR4)

GGN:	109299024(LGR4)

PSS:	102445269(LGR4)

CIZ:	142014697(LGR4)

CMY:	102942862(LGR4)

CCAY:

125638355(LGR4)

LKP:	140912766(LGR4)

NDS:	141988980(LGR4)

DCC:	119857917(LGR4)

CPIC:

101941887(LGR4)

TST:	117877082(LGR4)

EOB:	135877979(LGR4)

CABI:

116819264(LGR4)

MRV:	120404683(LGR4)

EMQ:	137142685(LGR4)

ACS:	100564212(lgr4)

ASAO:

132769245(LGR4)

PVT:	110077401(LGR4)

SUND:

121936262(LGR4)

PBI:	103048861(LGR4)

PMUR:

107286935(LGR4)

CTIG:

120318930(LGR4)

TSR:	106544759(LGR4)

PGUT:

117665402(LGR4)

PCAE:

139310678(LGR4)

APRI:

131187009(LGR4)

PTEX:

113440046(LGR4)

NSS:	113410277(LGR4)

VKO:	123021205(LGR4)

PMUA:

114597188(LGR4)

PRAF:

128414377(LGR4)

ZVI:	118086282(LGR4)

HCG:	128339362(LGR4)

GJA:	107122567(LGR4)

STOW:

125426164(LGR4)

EMC:	129324881(LGR4)

XLA:	108713818(lgr4.L) 734948(lgr4.S)

XTR:	100144922(lgr4)

NPR:	108796332(LGR4)

RTEM:

120917214(LGR4)

ACAT:

141112088(LGR4)

PADS:

140337947(LGR4)

BBUF:

120980379(LGR4)

BGAR:

122920654(LGR4)

DTC:	141088018(LGR4)

HSQ:	130276807(LGR4)

PCOB:

134968871(LGR4)

PWL:	138283836(LGR4)

MUO:	115468742(LGR4)

GSH:	117352232(LGR4)

DRE:	558825(lgr4)

DAES:

130232019(lgr4)

SRX:	107740414 107755070

SANH:

107663939(lgr4) 107700365

SGH:	107553053 107554901

CCAR:

109064402 122145779

CAUA:

113051554 113105972(lgr4)

CGIB:

127961906 128016938

PTET:

122348960(lgr4)

LROH:

127168273(lgr4)

GRF:	141331197(lgr4)

OMC:	131543777(lgr4)

PPRM:

120476010(lgr4)

RKG:	130083004(lgr4)

SCEP:

307155912(lgr4)

PPHX:

306994506(lgr4)

MAMB:

125264752(lgr4)

CIDE:

127515371

CERY:

137029816(lgr4)

MASI:

127443697 127454415

TROS:

130561371(lgr4)

TDW:	130423877(lgr4)

MANU:

129443310(lgr4)

PDAB:

135749299(lgr4)

IPU:

108259160

IFU:	128602638(lgr4)

PHYP:

113540913(lgr4)

SMEO:

124379855(lgr4)

TFD:	113636684(lgr4)

TVC:	132838511(lgr4)

CGAR:

128519156(lgr4)

NGRA:

132875317(lgr4)

TRN:	134304346(lgr4)

AMEX:

103024116(lgr4)

CMAO:

118817470(lgr4)

EEE:	113582090(lgr4)

CHAR:

105893106(lgr4)

SPIL:

134068678(lgr4)

ASAD:

121694377(lgr4)

TRU:	101066721(lgr4)

TFS:	130521873(lgr4)

TNG:	GSTEN00017867G001

NCC:	104940777(lgr4)

TBEN:

117471849(lgr4)

CGOB:

115028127(lgr4)

PGEO:

117466894(lgr4)

GACU:

117546792(lgr4)

EMAC:

134863684(lgr4)

ELY:	117257471(lgr4)

EFO:	125900535(lgr4)

PLEP:

121948340(lgr4)

SLUC:

116067779(lgr4)

SVIT:

144516167(lgr4)

ECRA:

117949762(lgr4)

ESP:

116677997

PFLV:

114552650(lgr4)

PFLT:

120555551(lgr4)

GAT:	120835391(lgr4)

PPUG:

119226459(lgr4)

AFB:	129102750(lgr4)

CLUM:

117749613(lgr4)

PSWI:

130192365(lgr4)

CANA:

137787767(lgr4)

TBU:	306736027(lgr4)

CVE:	137887387(lgr4)

AMIR:

142970098(lgr4)

MSAM:

119889786(lgr4)

SCHU:

122880948(lgr4)

EARM:

139281899(lgr4)

CUD:	121512261(lgr4)

SPUL:

138590993(lgr4)

LMIX:

132973405(lgr4)

HTC:	141787448(lgr4)

ALAT:

119017737(lgr4)

ASTR:

137600918(lgr4)

PKLU:

139203160(lgr4)

LCO:	104919249(lgr4)

AMMM:

307250450(lgr4)

MZE:	101485594(lgr4)

ONL:	100705147(lgr4)

OAU:	116327177(lgr4)

OLA:	101167435(lgr4)

OML:	112160512(lgr4)

CSAI:

133461325(lgr4)

XMA:	102229023(lgr4)

XCO:	114142901(lgr4)

XHE:	116718323(lgr4)

PRET:

103462401(lgr4)

PFOR:

103139316 103139405

PLAI:

106945289 106946991

PMEI:

106909673 106909988

GAF:	122822246(lgr4)

PPRL:

129369674(lgr4)

CVG:	107091004(lgr4)

CTUL:

119782682(lgr4)

GMU:	124866895(lgr4)

NFU:	107381471(lgr4)

KMR:	108228691(lgr4)

ALIM:

106530444(lgr4)

NWH:	119425105(lgr4)

LTU:	140301986(lgr4)

TBT:	306757069(lgr4)

MCEP:

125005611(lgr4)

AOCE:

111567321(lgr4)

EJA:	138213012(lgr4)

BFRE:

138620453(lgr4)

LCF:

108889714

CSEM:

103378699(lgr4)

POV:	109625080(lgr4)

SSEN:

122772827(lgr4)

SSOE:

131459822(lgr4)

HHIP:

117757328(lgr4)

HSP:	118108568(lgr4)

PPLT:

128453339(lgr4)

SMAU:

118302073(lgr4)

SDU:	111238373(lgr4)

SLAL:

111668339(lgr4)

XGL:	120785543(lgr4)

HCQ:	109514301(lgr4)

SSCV:

125967658(lgr4)

SBIA:

133498531(lgr4)

PEE:	133399195(lgr4)

PTAO:

133470434(lgr4)

BPEC:

110172849(lgr4)

ENY:	140380637(lgr4)

MALB:

109964142(lgr4)

BSPL:

114851748(lgr4)

SJO:	128363432(lgr4)

SSCO:

133984250(lgr4)

TTY:	137181572(lgr4)

GMH:	115558650(lgr4)

ZFA:	307227967(lgr4)

SASA:

106562314 106563548 106587483

STRU:

115167119 115203215

OTW:	112249297 112263802

OMY:	110506651 110526521

OGO:	124033657 124035634

ONE:	115112416 115113706

OKI:	109888420 109895335

OKE:	118362587 118394187

OMM:	135550264 135558109

OCLA:

139384433 139411545

SALP:

111969136 111974945

SNH:	120024905(lgr4) 120047882

SFON:

129834626 129854375

CCLU:

121556304 123485585

OEP:	134027950(lgr4)

SFM:

108940035

PKI:	111843313 111850539

AANG:

118227580(lgr4)

AROT:

135255061(lgr4)

CCOG:

133131163(lgr4)

LOC:	102697400(lgr4)

PSPA:

121294492(lgr4) 121330192

ARUT:

117432064 117434997

PSEX:

120529702(lgr4)

LCM:	102355209(LGR4)

CMK:	103174981(lgr4)

RTP:	109915980(lgr4)

CPLA:

122557649(lgr4)

CPUN:

140493808(lgr4)

HOC:	132824500(lgr4)

SCAU:

119971949(lgr4)

LERI:

129705557(lgr4)

HAKA:

140729665(lgr4)

PMRN:

116939855(LGR5) 116945542

LRJ:	133350365 133351526

BBEL:

CRG:

PDAM:

SPIS:

Reference

PMID:15192078

Authors

Mazerbourg S, Bouley DM, Sudo S, Klein CA, Zhang JV, Kawamura K, Goodrich LV, Rayburn H, Tessier-Lavigne M, Hsueh AJ

Title

Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality.

Journal

Mol Endocrinol 18:2241-54 (2004)
DOI:10.1210/me.2004-0133

Sequence

[mmu:107515]

LinkDB

DBGET integrated database retrieval system