KEGG ORTHOLOGY: K04350

ORTHOLOGY: K04350

Entry

K04350                      KO

Symbol

RASGRP1

Name

RAS guanyl-releasing protein 1

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04611

Platelet activation

map04660

T cell receptor signaling pathway

map05200

Pathways in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Disease

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04350  RASGRP1; RAS guanyl-releasing protein 1
   04014 Ras signaling pathway
    K04350  RASGRP1; RAS guanyl-releasing protein 1
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04350  RASGRP1; RAS guanyl-releasing protein 1
   04660 T cell receptor signaling pathway
    K04350  RASGRP1; RAS guanyl-releasing protein 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04350  RASGRP1; RAS guanyl-releasing protein 1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04350  RASGRP1; RAS guanyl-releasing protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K04350  RASGRP1; RAS guanyl-releasing protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   K04350  RASGRP1; RAS guanyl-releasing protein 1

Other DBs

GO:

0005088

Genes

HSA:	10125(RASGRP1)

PTR:	453316(RASGRP1)

PPS:	100983198(RASGRP1)

GGO:	101132761(RASGRP1)

PON:	100451529(RASGRP1)

PPYG:

129013920(RASGRP1)

NLE:	100584529(RASGRP1)

HMH:	116481506(RASGRP1)

SSYN:

129482617(RASGRP1)

MCC:	703838(RASGRP1)

MCF:	102124752(RASGRP1)

MTHB:

126960104

MNI:	105492541(RASGRP1)

CSAB:

103245866(RASGRP1)

CATY:

105574148(RASGRP1)

PANU:

101004206(RASGRP1)

TGE:	112627599(RASGRP1)

MLEU:

105546197(RASGRP1)

RRO:	104659684(RASGRP1)

RBB:	108526992(RASGRP1)

TFN:	117070893(RASGRP1)

PTEH:

111554594(RASGRP1)

CANG:

105504984(RASGRP1)

CJC:	100390905(RASGRP1)

SBQ:	101030982(RASGRP1)

CIMI:

108306123(RASGRP1)

ANAN:

105725805(RASGRP1)

CSYR:

103266803(RASGRP1)

MMUR:

105872414(RASGRP1)

LCAT:

123621915(RASGRP1)

PCOQ:

105814272(RASGRP1)

OGA:	100948727(RASGRP1)

MMU:	19419(Rasgrp1)

MCAL:

110311236(Rasgrp1)

MPAH:

110317644(Rasgrp1)

RNO:	29434(Rasgrp1)

MCOC:

116090682(Rasgrp1)

ANU:	117703370(Rasgrp1)

ASYL:

127685727(Rasgrp1)

MUN:	110565085(Rasgrp1)

CGE:	100762037(Rasgrp1)

MAUA:

101844509(Rasgrp1)

PROB:

127221662(Rasgrp1)

PLEU:

114697520 114705910

MORG:

121465582(Rasgrp1)

MFOT:

126495464

AAMP:

119814508(Rasgrp1)

NGI:	103727451(Rasgrp1)

HGL:	101699646(Rasgrp1)

CPOC:

100735488(Rasgrp1)

CCAN:

109699067(Rasgrp1)

DORD:

105981023(Rasgrp1)

DSP:	122114558(Rasgrp1)

PLOP:

125340786(Rasgrp1)

NCAR:

124976078

MMMA:

107138242(Rasgrp1)

ITI:	101954284(Rasgrp1)

OCU:

100359319

OPI:	101521598(RASGRP1)

TUP:	102468376(RASGRP1)

GVR:	103597262(RASGRP1)

CFA:	478255(RASGRP1)

CLUD:

112676148(RASGRP1)

VVP:	112919851(RASGRP1)

VLG:	121484511(RASGRP1)

NPO:	129504178(RASGRP1)

AML:	100483012(RASGRP1)

UMR:	103673478(RASGRP1)

UAH:	113242056(RASGRP1)

UAR:	123804087(RASGRP1)

ELK:

111140724

LLV:

125104027

MPUF:

101670606(RASGRP1)

MNP:	131999617(RASGRP1)

MLK:	131836093(RASGRP1)

NVS:	122894136(RASGRP1)

ORO:	101372513(RASGRP1)

EJU:	114221473(RASGRP1)

ZCA:	113909981(RASGRP1)

MLX:	118003026(RASGRP1)

NSU:	110585551(RASGRP1)

LWW:	102740845(RASGRP1)

FCA:	101093110(RASGRP1)

PYU:	121041478(RASGRP1)

PCOO:

112855224(RASGRP1)

PBG:	122468800(RASGRP1)

PVIV:

125167681(RASGRP1)

LRUF:

124508723

LGF:	123583195(RASGRP1)

AJU:

106985820

PTG:	102957207(RASGRP1)

PPAD:

109263183(RASGRP1)

PUC:

125909827

PLEZ:

122222205(RASGRP1)

HHV:	120224815(RASGRP1)

BTA:	533125(RASGRP1)

BOM:	102272711(RASGRP1)

BIU:	109564913(RASGRP1)

BBUB:

102412333(RASGRP1)

BBIS:

104994391(RASGRP1)

CHX:	102173007(RASGRP1)

OAS:	101105504(RASGRP1)

BTAX:

128054167(RASGRP1)

CSUM:

138073148(RASGRP1)

ODA:	120853230(RASGRP1)

CCAD:

122443362(RASGRP1)

MREE:

136172067(RASGRP1)

OVR:	110152013(RASGRP1)

MBEZ:

129563041(RASGRP1)

SSC:	100522721(RASGRP1)

CFR:	102511050(RASGRP1)

CBAI:

105076883(RASGRP1)

CDK:	105096898(RASGRP1)

VPC:	102538823(RASGRP1)

BACU:

103019762(RASGRP1)

BMUS:

118891032(RASGRP1)

LVE:	103080961(RASGRP1)

OOR:	101284173(RASGRP1)

LALB:

132518996(RASGRP1)

DLE:	111181766(RASGRP1)

PCAD:

102981768(RASGRP1)

PSIU:

116749524(RASGRP1)

NASI:

112391219(RASGRP1)

ECB:	100071578(RASGRP1)

EPZ:	103560184(RASGRP1)

EAI:	106835159(RASGRP1)

MYB:	102262016(RASGRP1)

MYD:	102758449(RASGRP1)

MMYO:

118649584(RASGRP1)

MLF:	102440792(RASGRP1)

MDT:	132239164(RASGRP1)

MYUM:

139017186(RASGRP1)

PKL:	118723795(RASGRP1)

EFUS:

103287296(RASGRP1)

MNA:	107542952(RASGRP1)

DRO:	112311978(RASGRP1)

SHON:

118993611(RASGRP1)

AJM:	119048185(RASGRP1)

PDIC:

114492677(RASGRP1) 114505747

PHAS:

123808019(RASGRP1)

MMF:	118627541(RASGRP1)

PPAM:

129063058(RASGRP1)

HAI:	109393855(RASGRP1)

RFQ:	117023358(RASGRP1)

PALE:

102877927(RASGRP1)

PGIG:

120587204(RASGRP1)

PVP:	105288616(RASGRP1)

RAY:	107514450(RASGRP1)

MJV:	108397030(RASGRP1)

TOD:	119238466(RASGRP1)

SARA:

101549191(RASGRP1)

SFUM:

130041850(RASGRP1)

SETR:

126032385(RASGRP1)

LAV:	100667149(RASGRP1)

TMU:

101343790

ETF:	101655797(RASGRP1)

DNM:	101441784(RASGRP1)

MDO:	100031728(RASGRP1)

GAS:	123237919(RASGRP1)

SHR:	100923297(RASGRP1)

AFZ:

127549211

PCW:	110211064(RASGRP1)

TVP:	118859094(RASGRP1)

PBRV:

138175372(RASGRP1)

OAA:	100089033(RASGRP1)

TACU:

119920999(RASGRP1)

GGA:	423290(RASGRP1)

PCOC:

116229319(RASGRP1)

MGP:

100544082

CJO:	107314952(RASGRP1)

TPAI:

128086648(RASGRP1)

LMUT:

125694438(RASGRP1)

NMEL:

110401152(RASGRP1)

APLA:

101794229(RASGRP1)

ACYG:

106031708(RASGRP1)

CATA:

118244228(RASGRP1)

AFUL:

116490271(RASGRP1)

TGU:	100224858(RASGRP1)

LSR:	110475275(RASGRP1)

SCAN:

103826949(RASGRP1)

PMOA:

120500438(RASGRP1)

OTC:	121334601(RASGRP1)

PRUF:

121349565(RASGRP1)

ATRC:

139590021(RASGRP1)

GFR:	102045446(RASGRP1)

FAB:	101821862(RASGRP1)

OMA:	130253668(RASGRP1)

PHI:	102102932(RASGRP1)

PMAJ:

107205693(RASGRP1)

CCAE:

111930328(RASGRP1)

CCW:	104684250(RASGRP1)

CBRC:

103620993(RASGRP1)

ACOE:

138111605(RASGRP1)

ETL:	114055314(RASGRP1)

ZAB:	102069616(RASGRP1)

ZLE:	135448330(RASGRP1)

ACHL:

103803058(RASGRP1)

SVG:	106862301(RASGRP1)

MMEA:

130579320(RASGRP1)

HRT:	120754539(RASGRP1)

SATI:

136362681(RASGRP1)

CCIC:

134044845(RASGRP1)

FPG:	101916013(RASGRP1)

FCH:	102054590(RASGRP1)

CCRI:

104154863

NNT:	104399059(RASGRP1)

SHAB:

115606266(RASGRP1)

ACUN:

113480591(RASGRP1)

TALA:

104369551(RASGRP1)

ACHC:

115351945(RASGRP1)

HALD:

104322832(RASGRP1)

HLE:	104835984(RASGRP1)

AGEN:

126049473

HHAR:

128138078(RASGRP4) 128139704(RASGRP1)

GCL:

127017152

CSTI:

104559152(RASGRP1)

LDI:	104351578(RASGRP1)

MNB:	103780897(RASGRP1)

DPUB:

104306848(RASGRP1)

PPUS:

135177615(RASGRP1)

AVIT:

104267216(RASGRP1)

BRHI:

104501924(RASGRP1)

EGZ:	104122054(RASGRP1)

NNI:	104015904(RASGRP1)

PCRI:

104030328(RASGRP1)

PCAO:

104050957(RASGRP1)

PADL:

103914379(RASGRP1)

AFOR:

103904380(RASGRP1)

FGA:	104069801(RASGRP1)

GSTE:

104251002(RASGRP1)

CLV:	102091121(RASGRP1)

MUI:	104533237(RASGRP1)

PGUU:

104458343(RASGRP1)

PLET:

104614253(RASGRP1)

EHS:	104516030(RASGRP1)

CMAC:

104485396(RASGRP1)

CUCA:

104068806(RASGRP1)

TEO:	104369728(RASGRP1)

BREG:

104640810(RASGRP1)

OHA:	104326982(RASGRP1)

ACAR:

104526628(RASGRP1)

CPEA:

104397735(RASGRP1)

CVF:	104288159(RASGRP1)

RTD:	128908183(RASGRP1)

CRID:

134514617(RASGRP1)

AAM:	106483025(RASGRP1)

AROW:

112966178(RASGRP1)

NPD:	112958022(RASGRP1)

TGT:

104574300

DNE:	112979611(RASGRP1)

SCAM:

104153876(RASGRP1)

ASN:	102379336(RASGRP1)

AMJ:	106736825(RASGRP1)

CPOO:

109321262(RASGRP1)

GGN:	109298711(RASGRP1)

PSS:	102448788(RASGRP4) 102460370(RASGRP1)

CMY:	102941071(RASGRP1)

CCAY:

125639185(RASGRP1)

DCC:	119857950(RASGRP1)

CPIC:

101946271(RASGRP1)

TST:	117876677(RASGRP1)

CABI:

116829387(RASGRP1)

MRV:	120403385(RASGRP1)

ACS:	100563703(rasgrp1)

ASAO:

132765730(RASGRP1)

PVT:	110085751(RASGRP1)

SUND:

121918300(RASGRP1)

PBI:	103050553(RASGRP1)

PMUR:

107287220(RASGRP1)

CTIG:

120309783(RASGRP1)

TSR:	106550700(RASGRP1)

PGUT:

117665713(RASGRP1)

APRI:

131187670(RASGRP1)

PTEX:

113442707(RASGRP1)

NSS:	113410113(RASGRP1)

VKO:	123026763(RASGRP1)

PMUA:

114593501(RASGRP1)

PRAF:

128410493(RASGRP1)

ZVI:	118082795(RASGRP1)

HCG:	128334803(RASGRP1)

GJA:	107118948(RASGRP1)

STOW:

125427291(RASGRP1)

EMC:	129324835(RASGRP1) 129342995(RASGRP4)

XLA:	108698641(rasgrp4.L) 108699715(rasgrp1.S) 414479(rasgrp1.L)

XTR:	100101791(rasgrp1) 100496432(rasgrp4)

NPR:	108785170(RASGRP1)

RTEM:

120913404(RASGRP4) 120920649(RASGRP1)

BBUF:

120977119(RASGRP4) 120981955(RASGRP1)

BGAR:

122921545(RASGRP1) 122946357(RASGRP4)

PWL:	138259338 138260477(RASGRP1)

MUO:	115477070(RASGRP1) 115480181(RASGRP4)

GSH:	117357190 117363891(RASGRP1) 117365718(RASGRP4)

DRE:	558453(rasgrp4)

SRX:	107758090 107758237

SANH:

107662146 107676755

SGH:	107560135(rasgrp1) 107596887

CCAR:

109085837 109110085

CAUA:

113061684 113118451

CGIB:

127934026 127977002

PTET:

122362898(rasgrp4)

LROH:

127180619(rasgrp4)

OMC:	131524282(rasgrp4)

PPRM:

120487646(rasgrp4)

RKG:	130103869(rasgrp4)

MAMB:

125253718(rasgrp4)

CIDE:

127499309

CERY:

137023457(rasgrp4)

MASI:

127416991 127456492

TROS:

130562908(rasgrp4)

TDW:	130435720(rasgrp4)

MANU:

129419549(rasgrp4)

PDAB:

135769725 135773442

IPU:	108264291(rasgrp4) 108269613

IFU:	128606495(rasgrp4) 128612549

PHYP:

113526495 113538831

SMEO:

124390028 124396191(rasgrp4)

TFD:	113635393(rasgrp4) 113659595

TVC:	132850964(rasgrp4) 132851923

CGAR:

128528033(rasgrp4) 128535868

NGRA:

132887756(rasgrp4) 132893858

TRN:	134323020(rasgrp4) 134324951

AMEX:

103040566(rasgrp4) 103043117

CMAO:

118818114(rasgrp4) 118824094

EEE:	113579845 113589588

CHAR:

105897135(rasgrp4) 105909226

SPIL:

134067770 134099685(rasgrp4)

TRU:	101063560 101073008

TFS:	130534598(rasgrp4) 130540157

TNG:	GSTEN00032355G001 GSTEN00035197G001

LCO:	104921335(rasgrp1) 104934274

NCC:	104955748 104963649(rasgrp1)

TBEN:

117471105(rasgrp4) 117473473

CGOB:

115018298 115027612(rasgrp1)

PGEO:

117457133(rasgrp4) 117467730

GACU:

117550131 117555658(rasgrp4)

EMAC:

134880565(rasgrp4) 134881266

ELY:	117259102(rasgrp4) 117267630

EFO:	125888327(rasgrp4) 125900645

PLEP:

121943187(rasgrp4) 121953242

SLUC:

116035739 116040111(rasgrp4)

ECRA:

117935395 117941957(rasgrp4)

ESP:	116669677(rasgrp1) 116678184

PFLV:

114546691(rasgrp1) 114550240

GAT:	120819198(rasgrp4) 120832526

PPUG:

119211650(rasgrp4) 119228156

AFB:	129096197(rasgrp4) 129103122

CLUM:

117725166 117741287(rasgrp4)

PSWI:

130201278 130210364(rasgrp4)

CANA:

137787883 137790761(rasgrp4)

CVE:	137874704(rasgrp4) 137880277

MSAM:

119883549(rasgrp4) 119910297

SCHU:

122861870 122879077(rasgrp4)

CUD:	121523487(rasgrp4) 121526714

SPUL:

138591255 138596983(rasgrp4)

LMIX:

132980785(rasgrp4) 132992925

ALAT:

119004370 119034313(rasgrp4)

ASTR:

137596270(rasgrp4) 137610991

MZE:	101472166 101480824(rasgrp1)

ONL:	100699303(rasgrp1) 100709303

OAU:	116322318 116336491(rasgrp4)

OLA:	101159840 101169327(rasgrp1)

OML:	112143077 112149730(rasgrp4)

CSAI:

133442019(rasgrp4) 133461900

XMA:	102217156(rasgrp1) 102218567

XCO:	114133467 114134217(rasgrp1)

XHE:	116709027(rasgrp1) 116737673

PRET:

103458502(rasgrp1) 103475112

PFOR:

103136143(rasgrp1) 103138254

PLAI:

106957526(rasgrp1) 106959322

PMEI:

106903634(rasgrp1) 106918443

GAF:	122832873(rasgrp4) 122846293

PPRL:

129358793(rasgrp4) 129365396

CVG:	107091620 107097081(rasgrp1)

CTUL:

119785742(rasgrp4) 119787574

GMU:	124855519 124883903(rasgrp4)

NFU:	107379830 107392423(rasgrp1)

KMR:	108237197 108244670(rasgrp4)

ALIM:

106520349(rasgrp1) 106536568

NWH:	119411425(rasgrp4) 119427456

AOCE:

111579599(rasgrp4) 111583646

EJA:	138199831 138205267(rasgrp4)

BFRE:

138632741 138634230(rasgrp4)

MCEP:

125013080(rasgrp4) 125024017

CSEM:

103377852 103399991(rasgrp1)

POV:	109627793(rasgrp1) 109630234

SSEN:

122772980(rasgrp4) 122783041

SSOE:

131444580 131462361(rasgrp4)

HHIP:

117755762 117772376(rasgrp4)

HSP:	118105835(rasgrp4) 118116799

PPLT:

128440090(rasgrp4) 128450836

SMAU:

118285956 118298945(rasgrp4)

LCF:	108876155 108892564

SDU:	111216984 111225600(rasgrp1)

SLAL:

111662274 111663201(rasgrp1)

XGL:	120791491(rasgrp4) 120795857

HCQ:	109510720 109526140(rasgrp1)

SSCV:

125972053(rasgrp4) 125980412

SBIA:

133504514(rasgrp4) 133513190

PEE:	133405070(rasgrp4) 133412567

PTAO:

133481959(rasgrp4) 133487972

BPEC:

110155573(rasgrp1) 110163618

ENY:	140366220(rasgrp4) 140370376

MALB:

109963281 109967968(rasgrp1)

BSPL:

114848725 114868422(rasgrp4)

SJO:	128360203(rasgrp4) 128375198

SSCO:

133980935(rasgrp4) 134000509

GMH:	115543931 115560781

SASA:

106589171 106591819 106611065

STRU:

115162350 115172632

OTW:	112233152 112255826(rasgrp4) 112256680

OMY:	110497935 110503271(rasgrp4) 110505526

OGO:	124001803 124006492(rasgrp4) 124046445

ONE:	115126888 115138490 115146238

OKI:	109894512 109904039 109909510

OKE:	118362474 118368321 118381424(rasgrp4)

OMM:	135508227 135525889 135546726(rasgrp4)

OCLA:

139375232 139382670 139382941 139383864

SALP:

111963252 111968749 112075550

SNH:	120023444 120060220

CCLU:

121539267 121544921 121567836(rasgrp4)

ELS:	105015690(rasgrp1) 105027019

OEP:	134026997 134028695(rasgrp4)

SFM:	108919613(rasgrp1) 108924841 108941108

PKI:	111838048 111838912(rasgrp1) 111841509

AANG:

118208156 118208937 118235882

AROT:

135235556 135250725 135263959

CCOG:

133107778 133132302 133137917

LOC:	102683591(rasgrp1) 102685434(rasgrp4)

PSPA:

121303827 121305004 121324390 121330319

ARUT:

117394354 117415502 117422022 117422376

PSEX:

120518574 120540219(rasgrp4)

LCM:	102345538(RASGRP4) 102347423(RASGRP1)

CMK:	103175195 103190331

RTP:

109917267

CPLA:

122542873(rasgrp4) 122553731

HOC:	132818152 132836547(rasgrp4)

LERI:

129700327 129714274(rasgrp4)

CIN:

OSN:

ATEN:

ADF:

XEN:

HSY:

Reference

PMID:21779502

Authors

Stone JC

Title

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.

Journal

Genes Cancer 2:320-34 (2011)
DOI:10.1177/1947601911408082

Reference

PMID:9789079

Authors

Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM

Title

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.

Journal

Proc Natl Acad Sci U S A 95:13278-83 (1998)
DOI:10.1073/pnas.95.22.13278

Sequence

[hsa:10125]

LinkDB

DBGET integrated database retrieval system